Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cui G et al. | Gossypol with methyltestosterone and ethinylestradiol male does not affect rat spermatogonial stem cell differentiation. | 2007 Mar-Apr | Arch. Androl. | pmid:17453689 |
Herrera J et al. | Modifications in the testis steroidogenic pathways in rats fed with cottonseed flour. | 1984 | Arch. Androl. | pmid:6236762 |
Tso WW et al. | Effect of gossypol on boar spermatozoal adenosine triphosphate metabolism. | 1982 | Arch. Androl. | pmid:6219642 |
Bressani R et al. | [Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum]. | 1975 | Arch Latinoam Nutr | pmid:1174302 |
Mayorga H et al. | [Extraction and precipitation of cottonseed protein by the wet method]. | 1973 | Arch Latinoam Nutr | pmid:4801265 |
Braham JE et al. | [Gossypol absorption in rats and in pigs]. | 1971 | Arch Latinoam Nutr | pmid:5172839 |
Rolz C et al. | [Method of wet concentration of protein of cotton seed cake processed by screw press]. | 1971 | Arch Latinoam Nutr | pmid:5172841 |
Leal-Garza CH et al. | [Frequency of sister chromatid exchange in mice treated with gossypol]. | 1990 Jul-Sep | Arch Invest Med (Mex) | pmid:2131768 |
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Jensen EC et al. | Lipoxygenase inhibitors shift the yeast/mycelium dimorphism in Ceratocystis ulmi. | 1992 | Appl. Environ. Microbiol. | pmid:1514797 |
Margalith P | Inhibitory effect of gossypol on microorganisms. | 1967 | Appl Microbiol | pmid:6049314 |
Alarcón B et al. | Screening for new compounds with antiherpes activity. | 1984 | Antiviral Res. | pmid:6517562 |
An T et al. | Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1. | 2012 | Antiviral Res. | pmid:22426469 |
Lin TS et al. | Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol. | 1989 | Antimicrob. Agents Chemother. | pmid:2619282 |
Schteingart DE et al. | Expression of anti-apoptosis genes determines the response of adrenal cancer to apoptosis-inducing chemotherapy. | 2010 | Anticancer Res. | pmid:21187456 |
Ye W et al. | Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. | 2007 Jan-Feb | Anticancer Res. | pmid:17352222 |
Jiang J et al. | The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. | 2004 Jan-Feb | Anticancer Res. | pmid:15015581 |
Brandes AA et al. | New drugs in recurrent high grade gliomas. | 2000 May-Jun | Anticancer Res. | pmid:10928126 |
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Huang YW et al. | Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. | 2006 May-Jun | Anticancer Res. | pmid:16827126 |
Thomas M et al. | Effects of gossypol on the cell cycle phases in T-47D human breast cancer cells. | 1991 Jul-Aug | Anticancer Res. | pmid:1746904 |
Zhong S et al. | Aromatase expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and suppressed by (-)-gossypol. | 2010 | Anticancer Res. | pmid:21187493 |
Shidaifat F et al. | Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle. | 1997 Mar-Apr | Anticancer Res. | pmid:9137441 |
Zhai G et al. | A liposomal delivery vehicle for the anticancer agent gossypol. | 2008 Sep-Oct | Anticancer Res. | pmid:19035313 |
Huang YW et al. | (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. | 2009 | Anticancer Res. | pmid:19528479 |
Reddish JM et al. | (-)-Gossypol containing hen sera and a myosin (-)-gossypol conjugate reduces the proliferation of MCF-7 cells. | 2010 | Anticancer Res. | pmid:20332451 |
Xu P et al. | Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. | 2009 | Anticancer Res. | pmid:20032412 |
Zhong S et al. | (-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. | 2013 | Anticancer Res. | pmid:23482766 |
Jiang J et al. | The effects of gossypol on the invasiveness of MAT-LyLu cells and MAT-LyLu cells from the metastasized lungs of MAT-LyLu-bearing Copenhagen rats. | 2000 Nov-Dec | Anticancer Res. | pmid:11205308 |
Jiang J et al. | Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells. | 2002 May-Jun | Anticancer Res. | pmid:12168828 |
Liu S et al. | The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. | 2002 Jan-Feb | Anticancer Res. | pmid:12017312 |
Shelley MD et al. | Structure-activity studies on gossypol in tumor cell lines. | 2000 | Anticancer Drugs | pmid:10831280 |
Sun J et al. | ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. | 2008 | Anticancer Drugs | pmid:18827561 |
Hedvat M et al. | Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. | 2012 | Anticancer Agents Med Chem | pmid:22931411 |
Khadzhibaev GS et al. | [Interferonogenic activity of gossypol, a low-molecular substance]. | 1978 | Antibiotiki | pmid:206198 |
Vichkanova SA et al. | [Antiviral properties of gossypol in experimental influenza pneumonia]. | 1970 | Antibiotiki | pmid:5501368 |
Vichkanova SA and Goriunova LV | [Study of virulicidal effect of gossypol in vitro]. | 1968 | Antibiotiki | pmid:4974209 |
SaÄitkulov AM et al. | [Relation between interferon-inducing activity of natural interferon inducers and their chemical structure]. | 1991 | Antibiot. Khimioter. | pmid:1719947 |
Amanov N et al. | [Intestinal microbial ecology and its modulation under the influence of immunodepressants]. | 1989 | Antibiot. Khimioter. | pmid:2802878 |
Qian SZ and Wang ZG | Gossypol: a potential antifertility agent for males. | 1984 | Annu. Rev. Pharmacol. Toxicol. | pmid:6375548 |
Sonpavde G et al. | Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. | 2012 | Ann. Oncol. | pmid:22112969 |
Johnson PW | New targets for lymphoma treatment. | 2008 | Ann. Oncol. | pmid:18519406 |
Chadha S et al. | Alterations and reversibility of the effects of gossypol acetic acid on the intestinal uptake of end product nutrients in normal and protein calorie-malnourished male rats. | 1991 | Ann. Nutr. Metab. | pmid:1905512 |
Tvermyr SM et al. | Glucose metabolism in rat germ cells: mechanism of action of gossypol. | 1984 | Ann. N. Y. Acad. Sci. | pmid:6598341 |
Fody EP and Walker EM | Effects of drugs on the male and female reproductive systems. | 1985 Nov-Dec | Ann. Clin. Lab. Sci. | pmid:4062226 |
Kunesch N et al. | [Preparation of derivatives of the aldehydic functions of gossypol]. | 1990 | Ann Pharm Fr | pmid:2082795 |
Cornu A et al. | [Utilization of gossypol-free cottonseed and its by-products as human food]. | 1977 | Ann Nutr Aliment | pmid:579293 |
Ojha P et al. | Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. | 2008 | Anim. Reprod. Sci. | pmid:17207942 |
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