Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Benz C et al. | Lactic dehydrogenase isozymes, 31P magnetic resonance spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123. | 1987 | J. Clin. Invest. | pmid:3805280 |
Sein GM | The embryotoxic and immunodepressive effects of gossypol. | 1986 | Am. J. Chin. Med. | pmid:3799526 |
Stephens DT et al. | Kinetic characterization of the inhibition of purified cynomolgus monkey lactate dehydrogenase isozymes by gossypol. | 1986 Nov-Dec | J. Androl. | pmid:3793617 |
Chongthammakun S et al. | Effects of gossypol on human and monkey sperm motility in vitro. | 1986 | Contraception | pmid:3791997 |
Reyes J et al. | Membrane actions of male contraceptive gossypol tautomers. | 1986 | Biochim. Biophys. Acta | pmid:3778905 |
Hu F et al. | Gossypol effects on cultured normal and malignant melanocytes. | 1986 | In Vitro Cell. Dev. Biol. | pmid:3771439 |
Whaley KJ et al. | Monkey lactate dehydrogenase-C4 as a model for the interaction of enzymes with gossypol. | 1986 | Contraception | pmid:3769483 |
Tam SC | Acute hypokalemic effect of gossypol. | 1986 | Can. J. Physiol. Pharmacol. | pmid:3768796 |
Wichmann K et al. | Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism. | 1986 | Contraception | pmid:3757514 |
Joseph AE et al. | Cytotoxicity of enantiomers of gossypol. | 1986 | Br. J. Cancer | pmid:3756086 |
Burgos C et al. | In vitro inhibition by gossypol of oxidoreductases from human tissues. | 1986 | Biochem. Pharmacol. | pmid:3754138 |
Heywood R et al. | The toxicity of gossypol to the male rat. | 1986 | Toxicology | pmid:3750328 |
Ahluwalia B et al. | Morphologic and endocrine changes in the reproductive organs in rats implanted with gossypol acetate pellet in the testis. | 1986 Jul-Aug | J. Androl. | pmid:3745012 |
Sheriff DS et al. | Gossypol and lipid peroxidation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3740171 |
Morris ID et al. | Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers. | 1986 | J. Reprod. Fertil. | pmid:3735252 |
Walia V et al. | Effect of gossypol on peripheral blood cells. | 1986 | Indian J. Med. Res. | pmid:3733198 |
Medrano FJ and Andreu JM | Binding of gossypol to purified tubulin and inhibition of its assembly into microtubules. | 1986 | Eur. J. Biochem. | pmid:3732269 |
Wong YK and Li JH | [Quantum pharmacological investigations of gossypol and some simple aromatic compounds]. | 1986 | Yao Xue Xue Bao | pmid:3728037 |
Pelletier RM and Friend DS | Sertoli cell junctional complexes in gossypol-treated neonatal and adult guinea pigs. | 1986 May-Jun | J. Androl. | pmid:3721997 |
Wu DF et al. | Pharmacokinetics of (+/-)-, (+)-, and (-)-gossypol in humans and dogs. | 1986 | Clin. Pharmacol. Ther. | pmid:3709025 |
Schmidt JH and Wells R | Recovery of soluble proteins from glanded cotton tissues with amines. | 1986 | Anal. Biochem. | pmid:3706729 |
Eisele GR | A perspective on gossypol ingestion in swine. | 1986 | Vet Hum Toxicol | pmid:3705437 |
Rosenberg LJ et al. | Inhibition of DNA polymerase alpha by gossypol. | 1986 | Biochim. Biophys. Acta | pmid:3697356 |
Ye YX et al. | Cardiodepressant actions of the orally active male contraceptive, gossypol, in guinea-pig heart muscle. | 1987 | Eur. J. Pharmacol. | pmid:3691653 |
Hoffer AP et al. | Ultrastructural, fertility, and spermicidal studies with isomers and derivatives of gossypol in male hamsters. | 1987 | Biol. Reprod. | pmid:3689857 |
Buttar HS and Nayak BN | Cytogenetic effects of vaginally administered gossypol in murine bone marrow cells. | 1987 | Toxicol. Lett. | pmid:3660427 |
Yang YQ and Wu XY | Antifertility mechanisms of gossypol acetic acid in female rats. | 1987 | J. Reprod. Fertil. | pmid:3656277 |
Glander HJ | [Comments on reversible nonhormonal contraception in the male]. | 1987 | Hautarzt | pmid:3654202 |
Lindberg MC et al. | Comparative anti-fertility effects of gossypol enantiomers in male hamsters. | 1987 | Int. J. Androl. | pmid:3654015 |
pmid:3631888 | ||||
Chen QQ et al. | Comparative study on the metabolism of optical gossypol in rats. | 1987 | J Ethnopharmacol | pmid:3626594 |
Yao KQ et al. | Effect of (+/-)-, (+)- and (-)-gossypol on the lactate dehydrogenase-X activity of rat testis. | 1987 | J Ethnopharmacol | pmid:3626593 |
Wang NG et al. | Effect of (-)- and (+)-gossypol on fertility in male rats. | 1987 | J Ethnopharmacol | pmid:3626592 |
Huang L et al. | Resolution of racemic gossypol. | 1987 | J Ethnopharmacol | pmid:3626591 |
Wang MZ | Analysis of gossypol by high performance liquid chromatography. | 1987 | J Ethnopharmacol | pmid:3626590 |
Zakhidov ST et al. | [Cytogenetic study of the effect of gossypol on mouse germ cells]. | 1987 | Genetika | pmid:3623090 |
Sinha Hikim AP and Hoffer AP | Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol. | 1987 | Contraception | pmid:3621939 |
Srivastava AK and Padmanaban G | Gossypol mediated DNA degradation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619941 |
Kim I et al. | Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. | 1987 | Contraception | pmid:3608484 |
Hadley MA and Burgos MH | Gossypol injected in the rat epididymal fat pad inhibits epididymal sperm motility. | 1986 | Microsc Electron Biol Celular | pmid:3587061 |
Wu YW et al. | [Electrophysiological and ultrastructural studies of the blood-epididymis barrier of the rat]. | 1986 | Shi Yan Sheng Wu Xue Bao | pmid:3577546 |
Giridharan N et al. | Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats. | 1987 | Contraception | pmid:3568662 |
Suzuki H et al. | [Studies on naturally occurring toxic substances (III). Determination of gossypol in seed kernels of cotton plants by high performance liquid chromatography]. | 1986 | Eisei Shikenjo Hokoku | pmid:3567428 |
de Peyster A et al. | Membrane structural/functional perturbations induced by gossypol. Effects on membrane order, liposome permeability, and insulin-sensitive hexose transport. | 1986 | Biochem. Pharmacol. | pmid:3533079 |
Henderson J et al. | Occupation-related male infertility: a review. | 1986 | Clin Reprod Fertil | pmid:3527400 |
Baccetti B et al. | Action of gossypol on rat germinal cells. II. The acrosome. | 1987 | Gamete Res | pmid:3506897 |
Alheid U et al. | Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. | 1987 | Thromb. Res. | pmid:3499684 |
Förstermann U et al. | Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3487639 |
Dhaliwal MK et al. | Cytogenetic analysis of a gossypol-induced murine myxosarcoma. | 1987 | J. Natl. Cancer Inst. | pmid:3473256 |
Kalla NR et al. | Involvement of prostaglandin in the antifertility effects of gossypol. | 1986 | Contraception | pmid:3465506 |