Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid:22711315 | ||||
Kanwar U et al. | Gossypol-induced inhibition of glucose uptake in human ejaculated spermatozoa may be mediated by lipid peroxidation. | 1990 | Contraception | pmid:2272185 |
Ignatova M et al. | Quaternized chitosan-coated nanofibrous materials containing gossypol: preparation by electrospinning, characterization and antiproliferative activity towards HeLa cells. | 2012 | Int J Pharm | pmid:22728261 |
Li HQ et al. | Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein. | 2012 | Bioorg. Med. Chem. | pmid:22739087 |
Sun P et al. | Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells. | 2012 | Oncol. Rep. | pmid:22766741 |
Cuéllar A et al. | Cholesterol side-chain cleavage and 11 beta-hydroxylation are inhibited by gossypol in adrenal cortex mitochondria. | 1990 | J. Steroid Biochem. Mol. Biol. | pmid:2278843 |
Zheng DK et al. | [Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. | 1990 | Yao Xue Xue Bao | pmid:2284966 |
Si YK et al. | [Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. | 1990 | Yao Xue Xue Bao | pmid:2284967 |
Zheng DK et al. | [Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent]. | 1990 | Yao Xue Xue Bao | pmid:2284968 |
Balakrishnan K et al. | Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. | 2013 | Leuk. Lymphoma | pmid:22866921 |
Hsiao WT et al. | Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. | 2012 | Mol. Vis. | pmid:22876131 |
Jackson RS et al. | Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. | 2012 | Neoplasia | pmid:22904682 |
Ionov M et al. | Stability and antioxidant activity of gossypol derivative immobilized on N-polyvinylpyrrolidone. | 2012 | Int. J. Biol. Macromol. | pmid:22910577 |
Wang AP et al. | Effects of different sources and levels of dietary gossypol on gossypol residues in plasma and milk of lactating cows. | 2012 | J. Dairy Sci. | pmid:22916918 |
Schuler MA | Insect P450s: mounted for battle in their war against toxins. | 2012 | Mol. Ecol. | pmid:22924794 |
Hedvat M et al. | Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. | 2012 | Anticancer Agents Med Chem | pmid:22931411 |
Varadarajan S et al. | A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. | 2012 | Cell Death Differ. | pmid:22955944 |
Pond GR et al. | Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer. | 2012 | Clin Genitourin Cancer | pmid:23000202 |
Zbidah M et al. | Gossypol-induced suicidal erythrocyte death. | 2012 | Toxicology | pmid:23041711 |
Palle SR et al. | RNAi-mediated Ultra-low gossypol cottonseed trait: performance of transgenic lines under field conditions. | 2013 | Plant Biotechnol. J. | pmid:23078138 |
Hall C et al. | Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. | 2013 | Clin Genitourin Cancer | pmid:23083798 |
Sarwar Gilani G et al. | Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality. | 2012 | Br. J. Nutr. | pmid:23107545 |
Vshivkov S et al. | Capillary electrophoresis to quantitate gossypol enantiomers in cotton flower petals and seed. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23122406 |
Senarisoy M et al. | Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks. | 2013 | Cell Biochem. Biophys. | pmid:23161103 |
Thakur A et al. | Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. | 2012 | PLoS ONE | pmid:23185240 |
Xin J et al. | ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. | 2013 | Biomed. Pharmacother. | pmid:23201009 |
Song T et al. | 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. | 2013 | Bioorg. Med. Chem. | pmid:23206987 |
Zhang Z et al. | Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach. | 2013 | Eur J Med Chem | pmid:23220642 |
Wong FY et al. | Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. | 2012 | PLoS ONE | pmid:23226540 |
Cho H et al. | Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. | 2013 | J Control Release | pmid:23246471 |
Chatterjee TK and Bhatnagar RK | Ca2(+)-dependent, ATP-induced conversion of the [3H]hemicholinium-3 binding sites from high- to low-affinity states in rat striatum: effect of protein kinase inhibitors on this affinity conversion and synaptosomal choline transport. | 1990 | J. Neurochem. | pmid:2324736 |
Neild TO et al. | Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus. | 1990 | J. Physiol. (Lond.) | pmid:2324984 |
Ahn JH et al. | Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3-mimetic gossypol. | 2013 | J. Cell. Physiol. | pmid:23254564 |
Karaca B et al. | Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. | 2013 | Mol. Biol. Rep. | pmid:23269627 |
Warner TD | Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists. | 1990 | Br. J. Pharmacol. | pmid:2328405 |
Zhang Z et al. | Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors. | 2013 | Eur J Med Chem | pmid:23314054 |
Ansari N et al. | Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy. | 2013 | Methods Cell Biol. | pmid:23317907 |
Junco M et al. | Substrate-dependent inhibition of protein kinase C by specific inhibitors. | 1990 | FEBS Lett. | pmid:2332048 |
Goff DJ et al. | A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. | 2013 | Cell Stem Cell | pmid:23333150 |
Anderson MA et al. | BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia. | 2013 | Leuk. Lymphoma | pmid:23339446 |
Kannan A et al. | Effect of feeding of calcium hydroxide-treated or vitamin E-supplemented cottonseed meal on plasma gossypol levels, blood parameters, and performance of Bikaneri lambs. | 2013 | Trop Anim Health Prod | pmid:23345064 |
Wu DF and Reidenberg MM | Stereoselective interaction between gossypol and rat plasma. | 1990 | Contraception | pmid:2335102 |
Lin YC et al. | Effect of gossypol on thyroid hormones in young female rats. | 1990 | Contraception | pmid:2335106 |
Huo M et al. | Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models. | 2013 | Int. Immunopharmacol. | pmid:23352443 |
Cheng P et al. | The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. | 2013 | Cell Death Dis | pmid:23392177 |
Dézsi L et al. | Regulation of femoral vascular resistance by adenine nucleotides via endothelial and smooth muscle receptors. | 1990 | Acta Physiol Hung | pmid:2339604 |
Ni Z et al. | Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma. | 2013 | Leuk. Lymphoma | pmid:23398207 |
Prakash O and Khan F | Development of method for three-point data estimation and SVR-QSAR model to screen anti cancer leads. | 2013 | Comb. Chem. High Throughput Screen. | pmid:23410041 |
El-Nassan HB | Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. | 2013 | Eur J Med Chem | pmid:23434636 |
Liu Z et al. | Protective effect of gossypol on lipopolysaccharide-induced acute lung injury in mice. | 2013 | Inflamm. Res. | pmid:23435932 |