Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Varadarajan S et al. | Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. | 2013 | PLoS ONE | pmid:23457590 |
Mao YB et al. | Cysteine protease enhances plant-mediated bollworm RNA interference. | 2013 | Plant Mol. Biol. | pmid:23460027 |
Broderick GA et al. | Effect of replacing soybean meal protein with protein from upland cottonseed, Pima cottonseed, or extruded Pima cottonseed on production of lactating dairy cows. | 2013 | J. Dairy Sci. | pmid:23462167 |
Lohiya NK et al. | Limitations in developing gossypol acetic acid as a male contraceptive. | 1990 | Contraception | pmid:2347196 |
Hamdy R et al. | Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23474389 |
Zhong S et al. | (-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. | 2013 | Anticancer Res. | pmid:23482766 |
Fonseca NB et al. | Effectiveness of albumin-conjugated gossypol as an immunogen to prevent gossypol-associated acute hepatotoxicity in rats. | 2013 | Food Chem. Toxicol. | pmid:23485613 |
Pridgeon JW et al. | Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. | 2013 | Vaccine | pmid:23499519 |
Xin J et al. | ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo. | 2013 | Cancer Lett. | pmid:23523614 |
Wang J et al. | Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. | 2013 | Mol Biosyst | pmid:23532321 |
Yang J et al. | Synthesis and anti-H5N1 activity of chiral gossypol derivatives and its analogs implicated by a viral entry blocking mechanism. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23538114 |
Tang H et al. | Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones. | 2013 | PLoS ONE | pmid:23555724 |
Zelaya CA et al. | Di(phenylpropylamino)gossypol: a derivative of the dimeric natural product gossypol. | 2013 | Acta Crystallogr C | pmid:23579723 |
Mellon JE et al. | Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi. | 2013 | J. Appl. Microbiol. | pmid:23594138 |
Ye YX et al. | The modulation of gap junctional communication by gossypol in various mammalian cell lines in vitro. | 1990 | Fundam Appl Toxicol | pmid:2361580 |
Varadarajan S et al. | Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. | 2013 | Neoplasia | pmid:23633928 |
Pelosin JM et al. | Differential inhibition of protein kinase C subtypes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2363714 |
Soderquist R et al. | Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. | 2013 | Leukemia | pmid:23640104 |
Zhan YH et al. | Growth inhibition and apoptosis induction of human umbilical vein endothelial cells by apogossypolone. | 2013 | Asian Pac. J. Cancer Prev. | pmid:23679275 |
Lin J et al. | Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. | 2013 | Oncol. Rep. | pmid:23708869 |
Huang T et al. | Gossypol-induced alterations of aminophospholipid composition in human sperm. | 1990 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2371261 |
Rikihisa Y et al. | Taenia taeniaeformis: inactivation of metacestodes by gossypol in vitro. | 1990 | Exp. Parasitol. | pmid:2373186 |
Lin YL et al. | Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells. | 2013 | Mol. Pharm. | pmid:23734725 |
Kapoor S | Attenuating effect of gossypol on tumor growth in systemic malignancies. | 2013 | Cell Biochem. Biophys. | pmid:23743711 |
Botsoglou NA and Kufidis DC | Determination of total gossypol in cottonseed and cottonseed meals by derivative UV spectrophotometry. | 1990 May-Jun | J Assoc Off Anal Chem | pmid:2376551 |
Zhou M et al. | Metabolic engineering of gossypol in cotton. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23775273 |
Yuan Y et al. | Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. | 2013 | Cell Death Dis | pmid:23807219 |
Deng S et al. | Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. | 2013 | J. Vet. Sci. | pmid:23820203 |
Schelman WR et al. | A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer. | 2014 | Invest New Drugs | pmid:23860642 |
Guo JY et al. | Effects of high-gossypol cotton on the development and reproduction of Bemisia tabaci (Hemiptera: Aleyrodidae) MEAM1 cryptic species. | 2013 | J. Econ. Entomol. | pmid:23865205 |
Aletor VA and Onibi OE | Use of oyster shell as calcium supplement. Part 1. Effect on the utilization of gossypol-containing cotton seed cake by the chicken. | 1990 | Nahrung | pmid:2388684 |
Aletor VA and Aturamu OA | Use of oyster shell as calcium supplement. Part 2. An assessment of the responses of hepatic and serum enzymes, relative organ weights, and bone mineralization in the broiler chicken fed gossypol-containing cottonseed cake supplemented with oyster shell. | 1990 | Nahrung | pmid:2388685 |
Messiha FS | Gossypol modulation of mouse heart and liver lactate dehydrogenase isoenzymes as a function of gender. | 1990 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2396051 |
Billard C | BH3 mimetics: status of the field and new developments. | 2013 | Mol. Cancer Ther. | pmid:23974697 |
Jiao X et al. | Comparative transcriptomic analysis of developing cotton cotyledons and embryo axis. | 2013 | PLoS ONE | pmid:23977137 |
Song B et al. | Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways. | 2013 | Immunopharmacol Immunotoxicol | pmid:23981004 |
Gao W et al. | Proteomic and virus-induced gene silencing (VIGS) Analyses reveal that gossypol, brassinosteroids, and jasmonic acid contribute to the resistance of cotton to Verticillium dahliae. | 2013 | Mol. Cell Proteomics | pmid:24019146 |
Keshmiri-Neghab H and Goliaei B | Therapeutic potential of gossypol: an overview. | 2014 | Pharm Biol | pmid:24073600 |
Krasil'nikov OV et al. | [Dependence of the protonophore and channel-forming capacity of gossypol on the pH]. | 1985 | Dokl. Akad. Nauk SSSR | pmid:2408838 |
Zhang Z et al. | Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking. | 2013 | Eur J Med Chem | pmid:24095762 |
Lima Pde M et al. | Methane emission of Santa Inês sheep fed cottonseed by-products containing different levels of gossypol. | 2014 | Trop Anim Health Prod | pmid:24132456 |
Granchi C et al. | Small-molecule inhibitors of human LDH5. | 2013 | Future Med Chem | pmid:24175747 |
Kainz P et al. | The in vivo effect of gossypol on macromolecular synthesis in rat testis. | 1985 | Contraception | pmid:2419026 |
Haider SG et al. | Reversible changes in rat spermatogenesis induced by an antifertility substance (Gossypol). A histochemical report. | 1985 | Acta Histochem. | pmid:2420139 |
Kanje M et al. | The effect of gossypol on fast axonal transport and microtubule assembly. | 1986 | Biochim. Biophys. Acta | pmid:2421770 |
Paulus A et al. | AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia. | 2014 | Br. J. Haematol. | pmid:24236538 |
Ignatova M et al. | Quaternized chitosan-coated nanofibrous implants loaded with gossypol prepared by electrospinning and their efficacy against Graffi myeloid tumor. | 2014 | J Biomater Sci Polym Ed | pmid:24236801 |
Kogan P and Wald M | Male contraception: history and development. | 2014 | Urol. Clin. North Am. | pmid:24286773 |
Ershov FI et al. | [A new interferon inducer active via peroral administration]. | 1986 May-Jun | Vopr. Virusol. | pmid:2429451 |
Sonpavde G et al. | Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer. | 2014 | BJU Int. | pmid:24298897 |