Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gawande ND et al. | Molecular screening of insecticides with sigma glutathione S-transferases (GST) in cotton aphid Aphis gossypii using docking. | 2014 | Bioinformation | pmid:25512683 |
| Gadelha IC et al. | Gossypol promotes degeneration of ovarian follicles in rats. | 2014 | ScientificWorldJournal | pmid:25540815 |
| Jarzabek MA et al. | Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models. | 2014 | Br. J. Cancer | pmid:25375271 |
| Sadahira K et al. | Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. | 2014 | Int. J. Oncol. | pmid:25231749 |
| Xu R et al. | Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. | 2014 | Biomed Res Int | pmid:25197664 |
| Jin L et al. | Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a. | 2014 | Biomed Res Int | pmid:25180175 |
| Zhang X et al. | Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo. | 2014 | Mol Med Rep | pmid:25060748 |
| Gadelha IC et al. | Gossypol toxicity from cottonseed products. | 2014 | ScientificWorldJournal | pmid:24895646 |
| Qian C et al. | Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor. | 2014 | Drug Des Devel Ther | pmid:24872679 |
| Schelman WR et al. | A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer. | 2014 | Invest New Drugs | pmid:23860642 |
| Lima Pde M et al. | Methane emission of Santa Inês sheep fed cottonseed by-products containing different levels of gossypol. | 2014 | Trop Anim Health Prod | pmid:24132456 |
| Ignatova M et al. | Quaternized chitosan-coated nanofibrous implants loaded with gossypol prepared by electrospinning and their efficacy against Graffi myeloid tumor. | 2014 | J Biomater Sci Polym Ed | pmid:24236801 |
| Sorokina EV et al. | [Influence of immunovac-VP-4 therapy on innate immunity effectors in patients with darier erythema annulare centrifugum]. | 2013 Nov-Dec | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:24605681 |
| Lin YL et al. | Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells. | 2013 | Mol. Pharm. | pmid:23734725 |
| Pond GR et al. | Efficacy of docetaxel-based chemotherapy following ketoconazole in metastatic castration-resistant prostate cancer: implications for prior therapy in clinical trials. | 2013 | Urol. Oncol. | pmid:22552048 |
| Gao W et al. | Proteomic and virus-induced gene silencing (VIGS) Analyses reveal that gossypol, brassinosteroids, and jasmonic acid contribute to the resistance of cotton to Verticillium dahliae. | 2013 | Mol. Cell Proteomics | pmid:24019146 |
| Balakrishnan K et al. | Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. | 2013 | Leuk. Lymphoma | pmid:22866921 |
| Fonseca NB et al. | Effectiveness of albumin-conjugated gossypol as an immunogen to prevent gossypol-associated acute hepatotoxicity in rats. | 2013 | Food Chem. Toxicol. | pmid:23485613 |
| Prakash O and Khan F | Development of method for three-point data estimation and SVR-QSAR model to screen anti cancer leads. | 2013 | Comb. Chem. High Throughput Screen. | pmid:23410041 |
| Varadarajan S et al. | Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. | 2013 | PLoS ONE | pmid:23457590 |
| Mao YB et al. | Cysteine protease enhances plant-mediated bollworm RNA interference. | 2013 | Plant Mol. Biol. | pmid:23460027 |
| El-Nassan HB | Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. | 2013 | Eur J Med Chem | pmid:23434636 |
| Liu Z et al. | Protective effect of gossypol on lipopolysaccharide-induced acute lung injury in mice. | 2013 | Inflamm. Res. | pmid:23435932 |
| Pridgeon JW et al. | Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. | 2013 | Vaccine | pmid:23499519 |
| Hamdy R et al. | Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23474389 |
| Yuan Y et al. | Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. | 2013 | Cell Death Dis | pmid:23807219 |
| Deng S et al. | Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. | 2013 | J. Vet. Sci. | pmid:23820203 |
| Zhan YH et al. | Growth inhibition and apoptosis induction of human umbilical vein endothelial cells by apogossypolone. | 2013 | Asian Pac. J. Cancer Prev. | pmid:23679275 |
| Mellon JE et al. | Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi. | 2013 | J. Appl. Microbiol. | pmid:23594138 |
| Cho H et al. | Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. | 2013 | J Control Release | pmid:23246471 |
| Ahn JH et al. | Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3-mimetic gossypol. | 2013 | J. Cell. Physiol. | pmid:23254564 |
| Zhang Z et al. | Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach. | 2013 | Eur J Med Chem | pmid:23220642 |
| Xin J et al. | ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. | 2013 | Biomed. Pharmacother. | pmid:23201009 |
| Hall C et al. | Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. | 2013 | Clin Genitourin Cancer | pmid:23083798 |
| Palle SR et al. | RNAi-mediated Ultra-low gossypol cottonseed trait: performance of transgenic lines under field conditions. | 2013 | Plant Biotechnol. J. | pmid:23078138 |
| Zelaya CA et al. | Di(phenylpropylamino)gossypol: a derivative of the dimeric natural product gossypol. | 2013 | Acta Crystallogr C | pmid:23579723 |
| Wang J et al. | Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. | 2013 | Mol Biosyst | pmid:23532321 |
| Yang J et al. | Synthesis and anti-H5N1 activity of chiral gossypol derivatives and its analogs implicated by a viral entry blocking mechanism. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23538114 |
| Xin J et al. | ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo. | 2013 | Cancer Lett. | pmid:23523614 |
| Tang H et al. | Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones. | 2013 | PLoS ONE | pmid:23555724 |
| Broderick GA et al. | Effect of replacing soybean meal protein with protein from upland cottonseed, Pima cottonseed, or extruded Pima cottonseed on production of lactating dairy cows. | 2013 | J. Dairy Sci. | pmid:23462167 |
| Kapoor S | Attenuating effect of gossypol on tumor growth in systemic malignancies. | 2013 | Cell Biochem. Biophys. | pmid:23743711 |
| Lin J et al. | Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. | 2013 | Oncol. Rep. | pmid:23708869 |
| Zhou M et al. | Metabolic engineering of gossypol in cotton. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23775273 |
| Song B et al. | Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways. | 2013 | Immunopharmacol Immunotoxicol | pmid:23981004 |
| Billard C | BH3 mimetics: status of the field and new developments. | 2013 | Mol. Cancer Ther. | pmid:23974697 |
| Guo JY et al. | Effects of high-gossypol cotton on the development and reproduction of Bemisia tabaci (Hemiptera: Aleyrodidae) MEAM1 cryptic species. | 2013 | J. Econ. Entomol. | pmid:23865205 |
| Zhang Z et al. | Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking. | 2013 | Eur J Med Chem | pmid:24095762 |
| Sokolova TM et al. | Ridostin induces transcription of a wide spectrum of interferon genes in human cells. | 2013 | Bull. Exp. Biol. Med. | pmid:24319751 |
| Jiao X et al. | Comparative transcriptomic analysis of developing cotton cotyledons and embryo axis. | 2013 | PLoS ONE | pmid:23977137 |