Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lindsey TO et al. | Physiological responses of lactating cows to gossypol from cottonseed meal rations. | 1980 | J. Dairy Sci. | pmid:7189761 |
Chang MC et al. | Effects of Gossypol on the fertility of male rats, hamsters and rabbits. | 1980 | Contraception | pmid:7428357 |
Coulson PB et al. | Short term metabolic effects of the anti-fertility agent, gossypol, on various reproductive organs of male mice. | 1980 | Int. J. Androl. | pmid:7440012 |
Cheng KF et al. | Endometrial changes after administration of gossypol for menorrhagia. | 1980 | Am. J. Obstet. Gynecol. | pmid:7446637 |
Waller DP et al. | In vitjro spermicidal activity of gossypol. | 1980 | Contraception | pmid:7449381 |
Sang GW et al. | [Chronic toxicity of gossypol and the relationship to its metabolic fate in dogs and monkeys (author's transl)]. | 1980 | Zhongguo Yao Li Xue Bao | pmid:6461173 |
Han HL | [Gossypol treatment for menopausal functional bleeding, myoma of uterus and endometriosis--preliminary report (author's transl)]. | 1980 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6451316 |
Gossypol as an oral contraceptive for men. | 1980 | J Med Soc N J | pmid:6928215 | |
Gossypol--a new antifertility agent for males. | 1979 | Gynecol. Obstet. Invest. | pmid:393575 | |
Colman N et al. | Non-mutagenicity of gossypol in the Salmonella/mammalian-microsome plate assay. | 1979 | Environ Mutagen | pmid:399915 |
Qian SZ et al. | [The potassium-depleting effect of gossypol on isolated rabbit heart and it's possible mechanism (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:506710 |
de Buckle TS et al. | Two food applications of cottonseed flours and meals. | 1979 | J Am Oil Chem Soc | pmid:583421 |
Wang YE et al. | [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:583588 |
Chen ZC et al. | [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532653 |
Nadakavukaren MJ et al. | Effect of gossypol on the ultrastructure of rat spermatozoa. | 1979 | Cell Tissue Res. | pmid:535032 |
de Peyster A and Wang YY | Gossypol--proposed contraceptive for men passes the Ames test. | 1979 | N. Engl. J. Med. | pmid:450009 |
Havránek F | [Gossypol, a new contraceptive agent for men]. | 1979 | Cesk Gynekol | pmid:116775 |
Khadzhibaev GS et al. | [Interferonogenic activity of gossypol, a low-molecular substance]. | 1978 | Antibiotiki | pmid:206198 |
Aver'ianov AA and Merzliak MN | [Chemiluminescence during oxidation of gossipol by peroxidase]. | 1978 | Biokhimiia | pmid:214169 |
Alford BB and Onley K | The minimum cottonseed protein required for nitrogen balance in women. | 1978 | J. Nutr. | pmid:580097 |
Cherry JP et al. | Potential for improving cottonseed quality by genetic and agronomic practices. | 1978 | Adv. Exp. Med. Biol. | pmid:581532 |
Gossypol--a new antifertility agent for males. | 1978 | Chin. Med. J. | pmid:104833 | |
Jones LA and Smith FH | Effect of bound gossypol and amino acid supplementation of glandless cottonseed meal on the growth of weanling rats. | 1977 | J. Anim. Sci. | pmid:576596 |
Jones LA and Smith FH | Effect of gossypol on the removal of nitrogen and amino acids from feed in digestion by the rat. | 1977 | J. Anim. Sci. | pmid:576597 |
Cornu A et al. | [Utilization of gossypol-free cottonseed and its by-products as human food]. | 1977 | Ann Nutr Aliment | pmid:579293 |
Broderick GA | Effect of processing on protein utilization by ruminants. | 1977 | Adv. Exp. Med. Biol. | pmid:906927 |
Couch JR and Thomas MC | A comparison of chemical methods for the determination of available lysine in various proteins. | 1976 Sep-Oct | J. Agric. Food Chem. | pmid:989491 |
El-Nockrashy AS et al. | Biochemical changes in cottonseed during development and maturity. | 1976 | Nahrung | pmid:989153 |
El-DIN S and Aboul-Ela S | Fish meal supplementation of chick starting rations containing cottonseed cake. | 1976 | Beitr Trop Landwirtsch Veterinarmed | pmid:990100 |
Kulagin VI and Butov IuS | [Treatment of plantal warts in children]. | 1976 | Vestn Dermatol Venerol | pmid:997868 |
Roberts R | Protein products and hulls for animal foods. | 1976 | J Am Oil Chem Soc | pmid:932385 |
Skripkin IuK et al. | [Treatment of viral skin diseases with Soviet-made antiviral drugs]. | 1976 | Vestn Dermatol Venerol | pmid:1023645 |
Tone JN and Jensen DR | The accumulation pattern of ingested gossypol in selected organs of the rat. | 1976 | Experientia | pmid:1253913 |
Abou-Donia MB | Physiological effects and metabolism of gossypol. | 1976 | Residue Rev | pmid:778955 |
El-Nockrashy AS et al. | Cottonseed colour fixed pigments. Part I. Selectivity of hexane isomers. | 1976 | Nahrung | pmid:989152 |
Herman DL and Smith FH | Effect of free gossypol on tissue uptake of iron by everted segments of rat duodenum. | 1975 May-Jun | J. Agric. Food Chem. | pmid:1151001 |
Jones LA and Smith FH | Effect of free and bound gossypol on the absorption of L-]14-C]lysine, L-[14-C]methionine, and L-[14-C]valine from the rat small intestine. | 1975 Jul-Aug | J. Agric. Food Chem. | pmid:1141508 |
Damaty SM and Hudson BJ | Preparation of low-gossypol cottonseed flour. | 1975 | J. Sci. Food Agric. | pmid:1172995 |
Clawson AJ et al. | Unextracted cottonseed in diets for monogastric animals. I. The effect of ferrous sulfate and calcium hydroxide in reducing gossypol toxicity. | 1975 | J. Anim. Sci. | pmid:1173579 |
Bressani R et al. | [Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum]. | 1975 | Arch Latinoam Nutr | pmid:1174302 |
Braham JE and Bressani R | Effect of different levels of gossypol on transaminase activity, on nonessential to essential amino acid ratio, and on iron and nitrogen retention in rats. | 1975 | J. Nutr. | pmid:1117346 |
Damaty S and Hudson BJ | A secondary interaction between gossypol and cottonseed protein. | 1975 | Proc Nutr Soc | pmid:1187618 |
Jolad SD et al. | Tumor-inhibitory agent from Montezuma speciosissima (Malvaceae). | 1975 | J Pharm Sci | pmid:1195125 |
Abou-Donia MB and Dieckert JW | Metabolic fate of gossypol: the metabolism of [14-C]gossypol in swine. | 1975 | Toxicol. Appl. Pharmacol. | pmid:1129787 |
Dorsett PH et al. | Letter: Antiviral activity of gossypol and apogossypol. | 1975 | J Pharm Sci | pmid:1133739 |
Aripov UA et al. | [Immunodepressive properties of the drug "Batriden" in experiments on parabionts]. | 1975 | Dokl. Akad. Nauk SSSR | pmid:1140070 |
Pandey SN and Thejappa N | Study on relationship between oil, protein, and gossypol in cottonseed kernels. | 1975 | J Am Oil Chem Soc | pmid:1242138 |
Krylov VF | [Treatment of patients with influenza]. | 1975 | Ter. Arkh. | pmid:52894 |
Tone JN and Jensen DR | Hematological effects of injected gossypol and iron in rats. | 1974 Jan-Feb | J. Agric. Food Chem. | pmid:4811630 |
Abou-Donia MB and Dieckert JW | Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. | 1974 | Life Sci. | pmid:4277086 |