Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jiang DH and Xue H | [Monoanilinogossypol--the impurity possibly present in gossypol (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7102321 |
| Qian SZ et al. | [The potassium-depleting effect of gossypol on isolated rabbit heart and it's possible mechanism (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:506710 |
| Lei HP | [Review and prospect of gossypol research (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7090820 |
| Ye YX et al. | [The effect of gossypol on the incorporation of H3-thymidine in the liver, testis and small intestine of experimental animals (author's transl)]. | 1981 | Yao Xue Xue Bao | pmid:7246187 |
| Wang YE et al. | [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:583588 |
| Chen ZC et al. | [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532653 |
| Ma XN et al. | [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. | 1983 | Yao Xue Xue Bao | pmid:6433647 |
| Zhang ZR et al. | [High performance liquid chromatography of gossypol]. | 1984 | Yao Xue Xue Bao | pmid:6544029 |
| Wang NG et al. | [Effect of gossypol acetic acid on early pregnancy in rats]. | 1984 | Yao Xue Xue Bao | pmid:6544547 |
| Wang NG et al. | [Effects of (-) and (+) gossypol on the fertility of male rats]. | 1984 | Yao Xue Xue Bao | pmid:6544566 |
| Jiang Y and Zhou TH | [Polarographic study on gossypol]. | 1984 | Yao Xue Xue Bao | pmid:6496091 |
| Zhou LF and Lei HP | [Effect of gossypol acetic acid on the uterus and ovary]. | 1984 | Yao Xue Xue Bao | pmid:6496095 |
| Wang MZ et al. | [Determination of gossypol with high performance liquid chromatography]. | 1985 | Yao Xue Xue Bao | pmid:3834747 |
| Wong SM et al. | 14C-gossypol: optimum conditions for synthesis by cotton seedlings. | 1983 | Yao Xue Xue Bao | pmid:6687973 |
| Zheng DK et al. | [Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. | 1990 | Yao Xue Xue Bao | pmid:2284966 |
| Si YK et al. | [Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. | 1990 | Yao Xue Xue Bao | pmid:2284967 |
| Zheng DK et al. | [Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent]. | 1990 | Yao Xue Xue Bao | pmid:2284968 |
| Guo ZM et al. | [Synthesis of mono-aldehyde gossypol and its analogues]. | 1987 | Yao Xue Xue Bao | pmid:3450164 |
| Zhou RH and Lin XD | [Isolation of (-)-gossypol from natural plant]. | 1987 | Yao Xue Xue Bao | pmid:3450165 |
| Xu Y et al. | [The effect of combined use of gossypol and tripterygium wilfordii on the fertility of male rats]. | 1987 | Yao Xue Xue Bao | pmid:3452960 |
| Tang Y et al. | [Progress in small-molecule inhibitors of Bcl-2 family proteins]. | 2008 | Yao Xue Xue Bao | pmid:18819468 |
| Wu GP et al. | [Synthesis and antifertility actions of gossypol derivatives and phenol aldehydes]. | 1989 | Yao Xue Xue Bao | pmid:2618691 |
| Xiao DM et al. | [Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A]. | 1993 | Yao Xue Xue Bao | pmid:8285048 |
| Yuan XB et al. | [Study on polymorphism of gossypol by infrared spectrophotometry and X-ray diffraction]. | 1991 | Yao Xue Xue Bao | pmid:1950572 |
| Guan MZ and Wang NG | [Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats]. | 1996 | Yao Xue Xue Bao | pmid:8762457 |
| Wang WC et al. | [Changes of serum concentrations of testosterone, LH and FSH in men taking gossypol]. | 1985 | Yao Xue Xue Bao | pmid:3938917 |
| Chen Y et al. | [Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice]. | 1997 | Yao Xue Xue Bao | pmid:11596197 |
| Yang B et al. | [The effects of gossypol on rat luteal cells, human decidual cells and cytotrophoblasts]. | 1997 | Yao Xue Xue Bao | pmid:11596304 |
| Tang XC et al. | [Comparative studies on the absorption, distribution and excretion of 14C-gossypol in four species of animals (author's transl)]. | 1980 | Yao Xue Xue Bao | pmid:6779501 |
| Wang WH et al. | [Influence of salicylaldehyde and its analogs on the antispermatogenic effect of gossypol]. | 1985 | Yao Xue Xue Bao | pmid:4083027 |
| Swan MA et al. | Electron microscopic observations on the effect of gossypol on rat cauda epididymis. | 1990 | Z Mikrosk Anat Forsch | pmid:2220026 |
| Glander HJ | [Gossypol and other nonhormonal substances for the inhibition of male fertility]. | 1988 | Zentralbl Gynakol | pmid:3213305 |
| Madzhidov UV | [T-suppressors in experimental adjuvant arthritis and immunosuppression]. | 1984 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:6230839 |
| Sorokina EV et al. | [Influence of immunovac-VP-4 therapy on innate immunity effectors in patients with darier erythema annulare centrifugum]. | 2013 Nov-Dec | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:24605681 |
| Sorokina EV et al. | [Features of dynamics of sera cytokines in patients with erythema multiforme during immunotherapy]. | 2014 Jan-Feb | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:24738292 |
| Wang YF | [Late effect of gossypol treatment in gynecological diseases--a clinical study of 72 cases]. | 1985 | Zhong Xi Yi Jie He Za Zhi | pmid:3158438 |
| Huang HF and Wang M | [Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro]. | 1990 | Zhong Xi Yi Jie He Za Zhi | pmid:2208435 |
| Han ML | [Clinical observation of the gossypol treatment of endometriosis and uterine myoma and the location of the pharmacological action]. | 1982 | Zhong Xi Yi Jie He Za Zhi | pmid:6219819 |
| Ye XQ | [Clinical and experimental study of gossypol in the treatment of dysfunctional menorrhagia, endometriosis and fibromyoma of the uterus]. | 1988 | Zhong Xi Yi Jie He Za Zhi | pmid:3191544 |
| Wang WH | [Antagonistic effect of Smilax sp. on gossypol toxicity (author's transl)]. | 1982 | Zhong Yao Tong Bao | pmid:6212150 |
| Lv G et al. | [The effect of gossypol, praziquantel and artemether on recombinant lactate dehydrogenase from Schistosoma japonicum]. | 2007 | Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi | pmid:18441994 |
| Cheng W et al. | [Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541072 |
| Lin J et al. | [Effect of apogossypolone on induction apoptosis in multiple myeloma cells and its mechanisms]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:19236755 |
| Wang WQ et al. | [Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20030926 |
| Ye YX et al. | [Mode of inhibitory action of gossypol on Na+, K+-ATPase in vitro]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:3035869 |
| Sang GW et al. | [Chronic toxicity of gossypol and the relationship to its metabolic fate in dogs and monkeys (author's transl)]. | 1980 | Zhongguo Yao Li Xue Bao | pmid:6461173 |
| Shi QX et al. | [Analysis on exfoliated cells in human semen after oral administrations of gossypol acetic acid (author's transl)]. | 1981 | Zhongguo Yao Li Xue Bao | pmid:6462027 |
| Bi XF et al. | [Effects of potassium on the inhibitory effect of gossypol on Na,K-ATPase in vitro]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6087611 |
| Wang MS et al. | NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase isoforms in guinea pig kidney with gossypol inhibition. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10322899 |
| Zhao DP et al. | [Effect of gossypol formic acid on the fluidity of the spermatocyte plasma membrane of the rat]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2945391 |