Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pond GR et al. | Efficacy of docetaxel-based chemotherapy following ketoconazole in metastatic castration-resistant prostate cancer: implications for prior therapy in clinical trials. | 2013 | Urol. Oncol. | pmid:22552048 |
| Mellon JE et al. | Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi. | 2013 | J. Appl. Microbiol. | pmid:23594138 |
| Cho H et al. | Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. | 2013 | J Control Release | pmid:23246471 |
| Ahn JH et al. | Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3-mimetic gossypol. | 2013 | J. Cell. Physiol. | pmid:23254564 |
| Zhang Z et al. | Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach. | 2013 | Eur J Med Chem | pmid:23220642 |
| Xin J et al. | ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. | 2013 | Biomed. Pharmacother. | pmid:23201009 |
| Song T et al. | 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. | 2013 | Bioorg. Med. Chem. | pmid:23206987 |
| Cheng P et al. | The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. | 2013 | Cell Death Dis | pmid:23392177 |
| Ni Z et al. | Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma. | 2013 | Leuk. Lymphoma | pmid:23398207 |
| Huo M et al. | Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models. | 2013 | Int. Immunopharmacol. | pmid:23352443 |
| Goff DJ et al. | A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. | 2013 | Cell Stem Cell | pmid:23333150 |
| Guo JY et al. | Effects of high-gossypol cotton on the development and reproduction of Bemisia tabaci (Hemiptera: Aleyrodidae) MEAM1 cryptic species. | 2013 | J. Econ. Entomol. | pmid:23865205 |
| Zhang Z et al. | Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking. | 2013 | Eur J Med Chem | pmid:24095762 |
| Karaca B et al. | Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. | 2013 | Mol. Biol. Rep. | pmid:23269627 |
| Soderquist R et al. | Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. | 2013 | Leukemia | pmid:23640104 |
| Pond GR et al. | Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer. | 2012 | Clin Genitourin Cancer | pmid:23000202 |
| Sonpavde G et al. | Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. | 2012 | Ann. Oncol. | pmid:22112969 |
| Pond GR et al. | Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. | 2012 | Eur. Urol. | pmid:21715086 |
| Azab B et al. | Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells. | 2012 | J. Cell. Physiol. | pmid:21780116 |
| Imai A et al. | Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects. | 2012 | Cancer Res. | pmid:22158856 |
| Rathore KS et al. | Ultra-low gossypol cottonseed: generational stability of the seed-specific, RNAi-mediated phenotype and resumption of terpenoid profile following seed germination. | 2012 | Plant Biotechnol. J. | pmid:21902797 |
| Mazumder S et al. | Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells. | 2012 | Cancer Res. | pmid:22525702 |
| El-Mokadem MY et al. | Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams. | 2012 | J. Anim. Sci. | pmid:22585803 |
| Cheng W et al. | [Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541072 |
| Zhang YS et al. | Gossypol exhibits a strong influence towards UDP-glucuronosyltransferase (UGT) 1A1, 1A9 and 2B7-mediated metabolism of xenobiotics and endogenous substances. | 2012 | Molecules | pmid:22543504 |
| Zubair H et al. | Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage. | 2012 | Eur J Pharm Sci | pmid:22554693 |
| Yang X et al. | Identification and proteomic analysis of a novel gossypol-degrading fungal strain. | 2012 | J. Sci. Food Agric. | pmid:22002592 |
| Mellon JE et al. | Inhibitory effects of gossypol, gossypolone, and apogossypolone on a collection of economically important filamentous fungi. | 2012 | J. Agric. Food Chem. | pmid:22324794 |
| Ionov M et al. | Stability and antioxidant activity of gossypol derivative immobilized on N-polyvinylpyrrolidone. | 2012 | Int. J. Biol. Macromol. | pmid:22910577 |
| Hedvat M et al. | Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. | 2012 | Anticancer Agents Med Chem | pmid:22931411 |
| Varadarajan S et al. | A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. | 2012 | Cell Death Differ. | pmid:22955944 |
| Wang AP et al. | Effects of different sources and levels of dietary gossypol on gossypol residues in plasma and milk of lactating cows. | 2012 | J. Dairy Sci. | pmid:22916918 |
| Schuler MA | Insect P450s: mounted for battle in their war against toxins. | 2012 | Mol. Ecol. | pmid:22924794 |
| Yang J et al. | Synthesis and antiviral activities of novel gossypol derivatives. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22226654 |
| Jiang J et al. | Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling. | 2012 | Clin. Exp. Metastasis | pmid:22167622 |
| Lin H et al. | A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies. | 2012 | J Pharm Biomed Anal | pmid:22483642 |
| Billard C | Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia. | 2012 | Mol. Cancer Res. | pmid:22466256 |
| An T et al. | Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1. | 2012 | Antiviral Res. | pmid:22426469 |
| Tao XY et al. | Gossypol-enhanced P450 gene pool contributes to cotton bollworm tolerance to a pyrethroid insecticide. | 2012 | Mol. Ecol. | pmid:22515600 |
| Wagner TA et al. | Hemigossypol, a constituent in developing glanded cottonseed (Gossypium hirsutum). | 2012 | J. Agric. Food Chem. | pmid:22369216 |
| Kisim A et al. | Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22411600 |
| Bodur C and Basaga H | Bcl-2 inhibitors: emerging drugs in cancer therapy. | 2012 | Curr. Med. Chem. | pmid:22414090 |
| Hsiao WT et al. | Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. | 2012 | Mol. Vis. | pmid:22876131 |
| Wong FY et al. | Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. | 2012 | PLoS ONE | pmid:23226540 |
| Sarwar Gilani G et al. | Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality. | 2012 | Br. J. Nutr. | pmid:23107545 |
| Vshivkov S et al. | Capillary electrophoresis to quantitate gossypol enantiomers in cotton flower petals and seed. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23122406 |
| Zbidah M et al. | Gossypol-induced suicidal erythrocyte death. | 2012 | Toxicology | pmid:23041711 |
| Thakur A et al. | Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. | 2012 | PLoS ONE | pmid:23185240 |
| Jackson RS et al. | Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. | 2012 | Neoplasia | pmid:22904682 |
| Shen Y and Ye D | Re: Gregory R. Pond, Andrew J. Armstrong, Brian A. Wood, et al. Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. Eur Urol 2012;61:363-9. | 2012 | Eur. Urol. | pmid:21824719 |