Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Townsend BJ et al. | Antisense suppression of a (+)-delta-cadinene synthase gene in cotton prevents the induction of this defense response gene during bacterial blight infection but not its constitutive expression. | 2005 | Plant Physiol. | pmid:15849309 |
| Dodou K et al. | Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity. | 2005 | Bioorg. Med. Chem. | pmid:15878283 |
| Ergun U et al. | Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes. | 2005 | Cell Biol. Int. | pmid:15949956 |
| Conners R et al. | Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. | 2005 | Mol. Biochem. Parasitol. | pmid:15978953 |
| Wang J et al. | Development of competitive direct ELISA for gossypol analysis. | 2005 | J. Agric. Food Chem. | pmid:15998107 |
| Bauer JA et al. | Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL. | 2005 | Mol. Cancer Ther. | pmid:16020667 |
| Stipanovic RD et al. | Occurrence of (+)- and (-)-gossypol in wild species of cotton and in Gossypium hirsutum Var. marie-galante (Watt) Hutchinson. | 2005 | J. Agric. Food Chem. | pmid:16076104 |
| Santos JE et al. | Effects of source of gossypol and supplemental iron on plasma gossypol in Holstein steers. | 2005 | J. Dairy Sci. | pmid:16162530 |
| Lordelo MM et al. | Relative toxicity of gossypol enantiomers in broilers. | 2005 | Poult. Sci. | pmid:16206558 |
| Aregheore EM | A review of toxicity factors in some food and feedingstuffs in the nutrition of man and livestock in Nigeria. | 1992 | Vet Hum Toxicol | pmid:1621369 |
| Udoh P et al. | Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats. | 1992 | Contraception | pmid:1623720 |
| Lopez LM et al. | Nonhormonal drugs for contraception in men: a systematic review. | 2005 | Obstet Gynecol Surv | pmid:16250923 |
| Wang JM et al. | Differential binding of (+) and (-) gossypol to plasma protein and their entry into rat testis. | 1992 | J. Reprod. Fertil. | pmid:1625243 |
| Dodou K et al. | Investigations on gossypol: past and present developments. | 2005 | Expert Opin Investig Drugs | pmid:16255680 |
| Mohammad RM et al. | Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. | 2005 | Pancreas | pmid:16258364 |
| pmid:16305310 | ||||
| Moh PP et al. | Characteristics of covalent gossypol binding to microsomal proteins. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1636054 |
| Ojha P et al. | Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. | 2006 | Contraception | pmid:16371305 |
| Benedict CR et al. | The peroxidative coupling of hemigossypol to (+)- and (-)-gossypol in cottonseed extracts. | 2006 | Phytochemistry | pmid:16403543 |
| Gu Y and Lin YC | Suppression of adrenocorticotropic hormone (ACTH)-induced corticosterone secretion in cultured rat adrenocortical cells by gossypol and gossypolone. | 1991 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1647048 |
| Uzal FA et al. | Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding. | 2005 | J. Vet. Diagn. Invest. | pmid:16475530 |
| Yang G et al. | Molecular cloning and characterization of a novel lactate dehydrogenase gene from Clonorchis sinensis. | 2006 | Parasitol. Res. | pmid:16479375 |
| Wu YW et al. | Inhibitory effects of gossypol on adrenal function. | 1991 | Acta Endocrinol. | pmid:1648853 |
| Price CP et al. | Dissecting the behavior of a promiscuous solvate former. | 2006 | Angew. Chem. Int. Ed. Engl. | pmid:16493716 |
| Posevaia TA et al. | [The role of herpetic infection in epithelial dysplasias of the cervix uteri and a trial of their treatment with antiherpetic preparations]. | 1991 Jan-Feb | Vopr. Virusol. | pmid:1650068 |
| Stipanovic RD et al. | Ratios of (+)- and (-)-gossypol in leaves, stems, and roots of selected accessions of Gossypium hirsutum var. marie galante (Watt) Hutchinson. | 2006 | J. Agric. Food Chem. | pmid:16506812 |
| Przybylski P et al. | 1H- and 13C-NMR, FTIR, UV-VIS, ESI-MS, and PM5 studies as well as emission properties of a new Schiff base of gossypol with 5-methoxytryptamine and a new hydrazone of gossypol with dansylhydrazine. | 2006 | Biopolymers | pmid:16538663 |
| Wolter KG et al. | (-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. | 2006 | Neoplasia | pmid:16611409 |
| Zheng YH et al. | [Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells]. | 1991 | Yao Xue Xue Bao | pmid:1668561 |
| Galvão KN et al. | Embryo survival from gossypol-fed heifers after transfer to lactating cows treated with human chorionic gonadotropin. | 2006 | J. Dairy Sci. | pmid:16702269 |
| Stipanovic RD et al. | Effect of racemic and (+)- and (-)-gossypol on the survival and development of Helicoverpa zea larvae. | 2006 | J. Chem. Ecol. | pmid:16739016 |
| Przybylski P et al. | Multinuclear magnetic resonance, electrospray ionization-mass spectroscopy, and parametric method 5 studies of a new derivative of gossypol with 2-thiophenecarbohydrazide as well as its complexes with LI+, Na+, K+, RB+, and Cs+ cations. | 2006 | Biopolymers | pmid:16741985 |
| Huang YW et al. | Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. | 2006 May-Jun | Anticancer Res. | pmid:16827126 |
| Zhang WJ et al. | Optimization of process parameters for reduction of gossypol levels in cottonseed meal by Candida tropicalis ZD-3 during solid substrate fermentation. | 2006 | Toxicon | pmid:16846625 |
| Coward L et al. | Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS. | 2006 | J Pharm Biomed Anal | pmid:16859853 |
| Cranston JJ et al. | Effects of feeding whole cottonseed and cottonseed products on performance and carcass characteristics of finishing beef cattle. | 2006 | J. Anim. Sci. | pmid:16864881 |
| Cleverley J | American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA. | 2006 | IDrugs | pmid:16871453 |
| Shen YL et al. | Determinations of the inclusion complex between gossypol and beta-cyclodextrin. | 2006 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:16877036 |
| Zhang WJ et al. | Effect of selected fungi on the reduction of gossypol levels and nutritional value during solid substrate fermentation of cottonseed meal. | 2006 | J Zhejiang Univ Sci B | pmid:16909468 |
| Akinola OB et al. | Proteinaceous diet inhibits gossypol-induced spermatotoxicity. | 2006 Jul-Sep | Eur J Histochem | pmid:16920644 |
| Lei X et al. | Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. | 2006 | FASEB J. | pmid:16935937 |
| Dale GL and Friese P | Bax activators potentiate coated-platelet formation. | 2006 | J. Thromb. Haemost. | pmid:16970802 |
| Wang G et al. | Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. | 2006 | J. Med. Chem. | pmid:17034116 |
| Kalla NR et al. | Response of hamster to the antifertility effect of gossypol. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:1706127 |
| Ranga A et al. | Effect of gossypol on the fertility of male rats. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:1706128 |
| Nogueda-Torres B et al. | Trypanocidal activity of 4 isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi. | 2001 Jan-Mar | Rev. Latinoam. Microbiol. | pmid:17061565 |
| Huang YW et al. | Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. | 2006 Sep-Oct | Anticancer Res. | pmid:17094491 |
| Liu F et al. | Pharmacophore identification of KSP inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17095225 |
| Song JJ et al. | Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. | 2007 | J. Biol. Chem. | pmid:17110373 |
| Sunilkumar G et al. | Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17110445 |