Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Uzal FA et al. | Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding. | 2005 | J. Vet. Diagn. Invest. | pmid:16475530 |
Gu Y and Lin YC | Suppression of adrenocorticotropic hormone (ACTH)-induced corticosterone secretion in cultured rat adrenocortical cells by gossypol and gossypolone. | 1991 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1647048 |
Benedict CR et al. | The peroxidative coupling of hemigossypol to (+)- and (-)-gossypol in cottonseed extracts. | 2006 | Phytochemistry | pmid:16403543 |
Ojha P et al. | Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. | 2006 | Contraception | pmid:16371305 |
Moh PP et al. | Characteristics of covalent gossypol binding to microsomal proteins. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1636054 |
pmid:16305310 | ||||
Mohammad RM et al. | Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. | 2005 | Pancreas | pmid:16258364 |
Dodou K et al. | Investigations on gossypol: past and present developments. | 2005 | Expert Opin Investig Drugs | pmid:16255680 |
Wang JM et al. | Differential binding of (+) and (-) gossypol to plasma protein and their entry into rat testis. | 1992 | J. Reprod. Fertil. | pmid:1625243 |
Lopez LM et al. | Nonhormonal drugs for contraception in men: a systematic review. | 2005 | Obstet Gynecol Surv | pmid:16250923 |
Udoh P et al. | Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats. | 1992 | Contraception | pmid:1623720 |
Aregheore EM | A review of toxicity factors in some food and feedingstuffs in the nutrition of man and livestock in Nigeria. | 1992 | Vet Hum Toxicol | pmid:1621369 |
Lordelo MM et al. | Relative toxicity of gossypol enantiomers in broilers. | 2005 | Poult. Sci. | pmid:16206558 |
Santos JE et al. | Effects of source of gossypol and supplemental iron on plasma gossypol in Holstein steers. | 2005 | J. Dairy Sci. | pmid:16162530 |
Stipanovic RD et al. | Occurrence of (+)- and (-)-gossypol in wild species of cotton and in Gossypium hirsutum Var. marie-galante (Watt) Hutchinson. | 2005 | J. Agric. Food Chem. | pmid:16076104 |
Bauer JA et al. | Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL. | 2005 | Mol. Cancer Ther. | pmid:16020667 |
Wang J et al. | Development of competitive direct ELISA for gossypol analysis. | 2005 | J. Agric. Food Chem. | pmid:15998107 |
Conners R et al. | Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. | 2005 | Mol. Biochem. Parasitol. | pmid:15978953 |
Ergun U et al. | Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes. | 2005 | Cell Biol. Int. | pmid:15949956 |
Dodou K et al. | Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity. | 2005 | Bioorg. Med. Chem. | pmid:15878283 |