Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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AMBROSE AM and ROBBINS DJ | Studies on the chronic oral toxicity of cottonseed meal and cottonseed pigment glands. | 1951 | J. Nutr. | pmid:14851050 |
GALLUP WD et al. | Comparative effect on vitamin A metabolism in sheep of urea, soybean oil meal and cottonseed meal as sources of protein. | 1951 | J. Anim. Sci. | pmid:14814051 |
PARHAM AP et al. | The influence of solvent extracted and hydraulic processed cottonseed meals upon performance and level of plasma carotene, vitamin A, and fat in the blood of wintering beef cows. | 1950 | J. Anim. Sci. | pmid:14794574 |
MARX MH | Note of depression of spontaneous running activity by the appetite depressant gossypol in rats. | 1950 | J Comp Physiol Psychol | pmid:14784530 |
Sabirova FM and Madaminov AA | [Anti-inflammatory activity of the novel water soluble gossipol derivative mebavine]. | 2003 Nov-Dec | Eksp Klin Farmakol | pmid:14743712 |
Abe F et al. | Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense. | 2004 | Biol. Pharm. Bull. | pmid:14709920 |
Cheng JS et al. | Effect of gossypol on intracellular Ca2+ regulation in human hepatoma cells. | 2003 | Chin J Physiol | pmid:14672280 |
Sheriff DS | Effect of gossypol on tissue levels of glutathione and thiobarbituric acid reactive products in rats. | 1992 | Indian J. Exp. Biol. | pmid:1459652 |
Kovacic P | Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. | 2003 | Curr. Med. Chem. | pmid:14529461 |
Aneja R et al. | Modulatory influence of tin-protoporphyrin on gossypol-induced alterations of heme oxygenase activity in male Wistar rats. | 2003 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:14527098 |
REISER R and FU HC | The mechanism of gossypol detoxification by ruminant animals. | 1962 | J. Nutr. | pmid:14491326 |
Tres LL et al. | Permeable collagen-glycosaminoglycan cross-linked copolymers for the study of biological responses of cocultured Sertoli and spermatogenic cells. | 1992 Jul-Sep | Cell Biol. Toxicol. | pmid:1446259 |
LYMAN CM et al. | Reactions of proteins with gossypol. | 1959 | Arch. Biochem. Biophys. | pmid:14419129 |
Lin YC et al. | Transfer of 3H-gossypol to neonatal rats via milk of nursing dams. | 1992 | Life Sci. | pmid:1435075 |
CASADY RB et al. | FURTHER STUDIES OF DEGOSSYPOLIZED COTTONSEED MEAL AS A SOURCE OF PLANT PROTEIN IN RABBIT FEEDS. | 1965 | J Am Oil Chem Soc | pmid:14328364 |
Risco CA et al. | Effect of graded concentrations of gossypol on calf performance: toxicological and pathological considerations. | 1992 | J. Dairy Sci. | pmid:1430484 |
DANKE RJ and TILLMAN AD | EFFECT OF GOSSYPOL AND HEXAHOMOSERINE ON PERFORMANCE OF RATS FED PURIFIED DIETS WITH AND WITHOUT LYSINE. | 1965 | J. Anim. Sci. | pmid:14296177 |
VERMEL EM and KRUGLYAK SA | ANTITUMOR ACTIVITY OF GOSSYPOL IN EXPERIMENTS ON TRANSPLANTABLE TUMORS. | 1965 Jan-Feb | Fed Proc Transl Suppl | pmid:14275562 |
SMITH FH | DETERMINATION OF FREE AND BOUND GOSSYPOL IN SWINE TISSUES. | 1965 | J Am Oil Chem Soc | pmid:14268479 |
BRESSANI R et al. | ALL-VEGETABLE PROTEIN MIXTURES FOR HUMAN FEEDING. XV. STUDIES IN DOGS ON THE ABSORPTION OF GASSYPOL FROM COTTONSEED FLOUR-CONTAINING VEGETABLE PROTEIN MIXTURES. | 1964 | J. Nutr. | pmid:14191421 |