Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: III. The activity for the transcription of messenger RNA. | 1992 | Contraception | pmid:1559338 |
Srivastava A et al. | Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. | 1989 | Contraception | pmid:2469550 |
Moore GD et al. | Inhibition of sperm migration, fertilization and implantation in rats by precoital intrauterine administration of gossypol or nonoxynol-9. | 1988 | Contraception | pmid:2835205 |
Fu YF et al. | Effects of gossypol on the activity of kidney (Na+ + K+)-ATPase and the functions of erythrocyte membrane. | 1988 | Contraception | pmid:2836126 |
White IG et al. | Studies of the mechanism of action of gossypol as a male antifertility agent. | 1988 | Contraception | pmid:2836127 |
Hahn DW et al. | Antifertility and endocrine activities of gossypol in rodents. | 1981 | Contraception | pmid:7273769 |
Waller DP et al. | Antifertility effects of gossypol and its impurities on male hamsters. | 1981 | Contraception | pmid:7285581 |
Chang MC et al. | Effects of Gossypol on the fertility of male rats, hamsters and rabbits. | 1980 | Contraception | pmid:7428357 |
Sakesena SK et al. | Gossypol: its toxicological and endocrinological effects in male rabbits. | 1981 | Contraception | pmid:7297071 |
Tso WW and Lee CS | Variations of gossypol sensitivity in boar spermatozoal electron transport chain segments. | 1981 | Contraception | pmid:7318437 |
Tanphaichitr N and Fitzgerald LM | Adverse effects of gossypol analogs on TM4 cell mitochondrial function. | 1989 | Contraception | pmid:2752754 |
Whaley KJ et al. | Monkey lactate dehydrogenase-C4 as a model for the interaction of enzymes with gossypol. | 1986 | Contraception | pmid:3769483 |
Ojha P et al. | Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. | 2006 | Contraception | pmid:16371305 |
Ma XN and Back DJ | Inhibition of hepatic microsomal enzymes by gossypol in the rat. | 1984 | Contraception | pmid:6478834 |
International Symposium on Gossypol Research for Fertility Regulation. Wuhan, China, 15-17 October 1986. Representative papers. | 1988 | Contraception | pmid:3370985 | |
Zhong CQ et al. | Study on sperm function in men long after cessation of gossypol treatment. | 1990 | Contraception | pmid:2113849 |
Liu GZ et al. | Effects of K salt or a potassium blocker on gossypol-related hypokalemia. | 1988 | Contraception | pmid:3370986 |
Frick J et al. | Clinical microdose study of gossypol: effect on sperm motility and renal function. | 1988 | Contraception | pmid:3370988 |
Drayer DE and Reidenberg MM | Gossypol and Na+, K+ ATPase from human erythrocytes. | 1988 | Contraception | pmid:2848657 |
Xue SP et al. | Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. | 1988 | Contraception | pmid:3370989 |
Beaudoin AR | A developmental toxicity evaluation of gossypol. | 1988 | Contraception | pmid:3370993 |
Benz C et al. | Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy. | 1988 | Contraception | pmid:3370994 |
Matlin SA et al. | Large-scale resolution of gossypol enantiomers for biological evaluation. | 1988 | Contraception | pmid:3370995 |
Zhou RH and Lin XD | Isolation of (-)-gossypol from natural plant. | 1988 | Contraception | pmid:3370996 |
Sonenberg M et al. | Anti-fertility and other actions of gossypol analogues. | 1988 | Contraception | pmid:3370997 |
Ratsula K et al. | Vaginal contraception with gossypol: a clinical study. | 1983 | Contraception | pmid:6684533 |
Yang ZJ et al. | Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men. | 2004 | Contraception | pmid:15325889 |
Lohiya NK et al. | Limitations in developing gossypol acetic acid as a male contraceptive. | 1990 | Contraception | pmid:2347196 |
Kumar M et al. | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. | 1997 | Contraception | pmid:9408707 |
Wu DF and Reidenberg MM | Stereoselective interaction between gossypol and rat plasma. | 1990 | Contraception | pmid:2335102 |
Kim I et al. | Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. | 1987 | Contraception | pmid:3608484 |
Sinha Hikim AP and Hoffer AP | Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol. | 1987 | Contraception | pmid:3621939 |
Achedume AC et al. | Biochemical studies of the effect of gossypol consumption on cholesterol and residual glucose in fed and protein-energy deficient rats. | 1994 | Contraception | pmid:7813227 |
Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9013060 |
Bansode FW | Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia). | 1994 | Contraception | pmid:8070265 |
Kainz P et al. | The in vivo effect of gossypol on macromolecular synthesis in rat testis. | 1985 | Contraception | pmid:2419026 |
Bender HS et al. | A histopathologic study of the effects of gossypol on the female rat. | 1988 | Contraception | pmid:3197423 |
Nwoha PU | The blood constituents of gossypol-treated, protein-malnourished Wistar rats. | 1995 | Contraception | pmid:8605784 |
Nwoha PU and Aire TA | The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats. | 1995 | Contraception | pmid:8605785 |
Nwoha PU and Aire TA | Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine. | 1995 | Contraception | pmid:8605786 |
Orhan G et al. | The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index. | 1993 | Contraception | pmid:8508667 |
González-Garza MT et al. | Orally administered gossypol has no effect on eight hamster erythrocytic enzymes. | 1995 | Contraception | pmid:8749602 |
Wang C and Yeung RT | Gossypol and hypokalaemia. | 1985 | Contraception | pmid:3910352 |
Zhang SF et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: I. The activity for DNA synthesis. | 1989 | Contraception | pmid:2758843 |
Ye BK et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: II. The activity for the synthesis of cellular and nuclear basic proteins. | 1989 | Contraception | pmid:2758844 |
Wang JM et al. | The entry of gossypol across the blood-testis barrier in rats. | 1989 | Contraception | pmid:2721201 |
Wu YM et al. | Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. | 1981 | Contraception | pmid:6796329 |
Gu Y and Anderson NO | Effects of gossypol on the estrous cycle and ovarian weight in the rat. | 1985 | Contraception | pmid:4085249 |
Anuja MN et al. | Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative study with gossypol. | 2010 | Contraception | pmid:20851234 |
Coutinho EM | Gossypol: a contraceptive for men. | 2002 | Contraception | pmid:12020773 |