Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Morris ID | Gossypol: a male contraceptive with potential? | 1986 | IRCS J Med Sci | pmid:12280996 |
Zakhidov ST et al. | [Clastogenic action of gossypol on spermatogenic cells in rats studied by counting micronuclei]. | 1988 May-Jun | Izv Akad Nauk SSSR Biol | pmid:3411013 |
Zakhidov ST et al. | [The modifying cytogenetic effects of gossypol and its derivatives]. | 1994 Jul-Aug | Izv. Akad. Nauk. Ser. Biol. | pmid:7987209 |
Woolley RJ | Contraception--a look forward, Part II: Mifepristone and gossypol. | 1991 Mar-Apr | J Am Board Fam Pract | pmid:1823560 |
Lyman CM et al. | Metabolism of gossypol in the chick. | 1969 | J Am Oil Chem Soc | pmid:5779540 |
Roberts R | Protein products and hulls for animal foods. | 1976 | J Am Oil Chem Soc | pmid:932385 |
de Buckle TS et al. | Two food applications of cottonseed flours and meals. | 1979 | J Am Oil Chem Soc | pmid:583421 |
Pandey SN and Thejappa N | Study on relationship between oil, protein, and gossypol in cottonseed kernels. | 1975 | J Am Oil Chem Soc | pmid:1242138 |
SMITH FH | DETERMINATION OF FREE AND BOUND GOSSYPOL IN SWINE TISSUES. | 1965 | J Am Oil Chem Soc | pmid:14268479 |
Smith FH and Clawson AJ | The effects of dietary gossypol on animals. | 1970 | J Am Oil Chem Soc | pmid:5487114 |
Smith FH | Determination of gossypol in leaves and flower buds of Gossypium. | 1967 | J Am Oil Chem Soc | pmid:6041387 |
Muzaffaruddin M and Saxena ER | Physicochemical studies on the composition and stability of metal-gossypol complexes. I. Fe+++ gossypol complex. | 1966 | J Am Oil Chem Soc | pmid:5939582 |
Smith FH | Preparation of 14C-gossypol by incorporation of acetate-1-14C and acetate-2-14C by biosynthesis. | 1974 | J Am Oil Chem Soc | pmid:4415176 |
Skutches CL and Smith FH | Metabolism of gossypol, biosynthesized from methyl-14C-and carboxyl-14 C-labeled sodium acetate, in rat. | 1974 | J Am Oil Chem Soc | pmid:4479245 |
CASADY RB et al. | FURTHER STUDIES OF DEGOSSYPOLIZED COTTONSEED MEAL AS A SOURCE OF PLANT PROTEIN IN RABBIT FEEDS. | 1965 | J Am Oil Chem Soc | pmid:14328364 |
Lee KJ et al. | A mixture of cottonseed meal, soybean meal and animal byproduct mixture as a fish meal substitute: growth and tissue gossypol enantiomer in juvenile rainbow trout (Oncorhynchus mykiss). | 2002 | J Anim Physiol Anim Nutr (Berl) | pmid:15379906 |
Özdoğan M et al. | Effect of gossypol on blood serum parameters and small intestinal morphology of male broilers. | 2012 | J Anim Physiol Anim Nutr (Berl) | pmid:21261752 |
Akingbemi BT et al. | Ethanol intake may modify gossypol toxicosis in the rat. | 1996 Sep-Oct | J Appl Toxicol | pmid:8889787 |
Botsoglou NA and Kufidis DC | Determination of total gossypol in cottonseed and cottonseed meals by derivative UV spectrophotometry. | 1990 May-Jun | J Assoc Off Anal Chem | pmid:2376551 |
Ignatova M et al. | Quaternized chitosan-coated nanofibrous implants loaded with gossypol prepared by electrospinning and their efficacy against Graffi myeloid tumor. | 2014 | J Biomater Sci Polym Ed | pmid:24236801 |
Akagunduz O et al. | Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment. | 2010 Oct-Dec | J BUON | pmid:21229643 |
Karaca B et al. | Enhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7. | 2009 Jul-Sep | J BUON | pmid:19810142 |
MARX MH | Note of depression of spontaneous running activity by the appetite depressant gossypol in rats. | 1950 | J Comp Physiol Psychol | pmid:14784530 |
Cho H et al. | Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. | 2013 | J Control Release | pmid:23246471 |
El-Sebae AH et al. | Gossypol as an inducer or inhibitor in Spodoptera littoralis larvae. | 1981 | J Environ Sci Health B | pmid:6454717 |
Roychoudhury S et al. | In vitro gossypol induced spermatozoa motility alterations in rabbits. | 2009 | J Environ Sci Health B | pmid:20183084 |
Wang MZ | Analysis of gossypol by high performance liquid chromatography. | 1987 | J Ethnopharmacol | pmid:3626590 |
Huang L et al. | Resolution of racemic gossypol. | 1987 | J Ethnopharmacol | pmid:3626591 |
Wang NG et al. | Effect of (-)- and (+)-gossypol on fertility in male rats. | 1987 | J Ethnopharmacol | pmid:3626592 |
Yao KQ et al. | Effect of (+/-)-, (+)- and (-)-gossypol on the lactate dehydrogenase-X activity of rat testis. | 1987 | J Ethnopharmacol | pmid:3626593 |
Chen QQ et al. | Comparative study on the metabolism of optical gossypol in rats. | 1987 | J Ethnopharmacol | pmid:3626594 |
Yu YW | Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)- and (-)-stereoisomers. | 1987 | J Ethnopharmacol | pmid:3306161 |
Chang Q et al. | Effects of combined administration of low-dose gossypol with steroid hormones on the mitotic phase of spermatogenesis of rat. | 2010 | J Exp Zool A Ecol Genet Physiol | pmid:20839281 |
Przybylski P et al. | EI MS and ESI MS studies of the bisesquiterpene from cotton seeds: Gossypol and its Aza-derivatives. | 2008 | J Mass Spectrom | pmid:18200654 |
Przybylski P et al. | Complexes of heterocyclic aza-derivatives of phytoalexin from cotton plant-gossypol with alkali metal cations and perchlorate anion studied by ESI mass spectrometric method in the positive and negative modes. | 2009 | J Mass Spectrom | pmid:19189269 |
Taylor GT et al. | Search for a male contraceptive: the effect of gossypol on sexual motivation and epididymal sperm. | 1991 | J Med | pmid:2072049 |
Penningroth SM | Pharmacological basis of therapeutics: gossypol, an oral male contraceptive? | 1984 | J Med Soc N J | pmid:6592366 |
Gossypol as an oral contraceptive for men. | 1980 | J Med Soc N J | pmid:6928215 | |
Barak D et al. | Structural investigation of protein kinase C inhibitors. | 1991 | J Mol Struct | pmid:11538178 |
Coward L et al. | Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS. | 2006 | J Pharm Biomed Anal | pmid:16859853 |
Lin H et al. | A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies. | 2012 | J Pharm Biomed Anal | pmid:22483642 |
Jolad SD et al. | Tumor-inhibitory agent from Montezuma speciosissima (Malvaceae). | 1975 | J Pharm Sci | pmid:1195125 |
Dorsett PH et al. | Letter: Antiviral activity of gossypol and apogossypol. | 1975 | J Pharm Sci | pmid:1133739 |
Royer RE et al. | Binding of gossypol derivatives to human serum albumin. | 1988 | J Pharm Sci | pmid:3373428 |
Marcelle GB et al. | Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography. | 1984 | J Pharm Sci | pmid:6716251 |
Przybylski P et al. | Molecular structures and stability constants of gossypol and its aza-derivative complexes with silver(I) cations studied by potentiometric, ESI MS, NMR, and AM1d semiempirical methods. | 2008 | J Phys Chem A | pmid:18698745 |
Ouyang DY et al. | Valproic acid synergistically enhances the cytotoxicity of gossypol in DU145 prostate cancer cells: an iTRTAQ-based quantitative proteomic analysis. | 2011 | J Proteomics | pmid:21726675 |
Penrith ML et al. | Gossypol intoxication in pigs. | 1994 | J S Afr Vet Assoc | pmid:7602565 |
Heist RS et al. | Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer. | 2010 | J Thorac Oncol | pmid:20808253 |
Baggstrom MQ et al. | A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer. | 2011 | J Thorac Oncol | pmid:21918390 |