Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schmidt K et al. | EDRF-formation increases cGMP-levels in cultured endothelial cells. | 1990 | Adv. Second Messenger Phosphoprotein Res. | pmid:1976336 |
| Jaroszewski JW et al. | Action of gossypol and rhodamine 123 on wild type and multidrug-resistant MCF-7 human breast cancer cells: 31P nuclear magnetic resonance and toxicity studies. | 1990 | Cancer Res. | pmid:2208159 |
| Huang HF and Wang M | [Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro]. | 1990 | Zhong Xi Yi Jie He Za Zhi | pmid:2208435 |
| Swan MA et al. | Electron microscopic observations on the effect of gossypol on rat cauda epididymis. | 1990 | Z Mikrosk Anat Forsch | pmid:2220026 |
| Grando SA et al. | Clinical and laboratory evaluation of hemocarboadsorption in autoimmune bullous dermatoses. | 1990 | Int J Artif Organs | pmid:2189836 |
| Benz CC et al. | Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers. | 1990 | Mol. Pharmacol. | pmid:2193225 |
| Lohiya NK et al. | Limitations in developing gossypol acetic acid as a male contraceptive. | 1990 | Contraception | pmid:2347196 |
| Chatterjee TK and Bhatnagar RK | Ca2(+)-dependent, ATP-induced conversion of the [3H]hemicholinium-3 binding sites from high- to low-affinity states in rat striatum: effect of protein kinase inhibitors on this affinity conversion and synaptosomal choline transport. | 1990 | J. Neurochem. | pmid:2324736 |
| Neild TO et al. | Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus. | 1990 | J. Physiol. (Lond.) | pmid:2324984 |
| Warner TD | Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists. | 1990 | Br. J. Pharmacol. | pmid:2328405 |
| Wu DF and Reidenberg MM | Stereoselective interaction between gossypol and rat plasma. | 1990 | Contraception | pmid:2335102 |
| Lin YC et al. | Effect of gossypol on thyroid hormones in young female rats. | 1990 | Contraception | pmid:2335106 |
| Dézsi L et al. | Regulation of femoral vascular resistance by adenine nucleotides via endothelial and smooth muscle receptors. | 1990 | Acta Physiol Hung | pmid:2339604 |
| Kerr LA | Incidence and management of poisonings in livestock. | 1990 | Vet Hum Toxicol | pmid:2238452 |
| Gu ZP et al. | Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol. | 1990 | Int. J. Androl. | pmid:2117586 |
| Wiest E et al. | Removal of endothelial function in coronary resistance vessels by saponin. | 1989 Sep-Oct | Basic Res. Cardiol. | pmid:2818447 |
| Agarwal A | Antifertility and ultrastructural effects of optical isomers of gossypol administered intratesticularly in rats. | 1989 Nov-Dec | Acta Eur. Fertil. | pmid:2488986 |
| Achilova GSh et al. | [Antiviral activity of derivatives of aldehydophenols, aldehydo- naphthols and sugar derivatives]. | 1989 May-Jun | Vopr. Virusol. | pmid:2552684 |
| Tanphaichitr N and Fitzgerald LM | Incorporation of gossypol and formation of its protein conjugates in mouse transformed Sertoli (TM4) cells. | 1989 May-Jun | J. Androl. | pmid:2745232 |
| Gonzalez-Garza MT et al. | High susceptibility of five axenic Entamoeba histolytica strains to gossypol. | 1989 Jul-Aug | Trans. R. Soc. Trop. Med. Hyg. | pmid:2559507 |
| Srivastava A et al. | Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. | 1989 | Contraception | pmid:2469550 |
| Kaur S | Effect of gossypol on the concentration of sodium and potassium in the rat epididymis. | 1989 | Int. J. Androl. | pmid:2807585 |
| Molderings GJ et al. | Characterization of an endothelial 5-hydroxytryptamine (5-HT) receptor mediating relaxation of the porcine coronary artery. | 1989 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2812041 |
| Tanphaichitr N and Fitzgerald LM | Adverse effects of gossypol analogs on TM4 cell mitochondrial function. | 1989 | Contraception | pmid:2752754 |
| Tanphaichitr N et al. | Inhibitory effects of gossypol analogs on human sperm motility. | 1989 | Contraception | pmid:2752755 |
| Laughton MJ et al. | Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. | 1989 | Biochem. Pharmacol. | pmid:2476132 |
| Rikihisa Y and Lin YC | Effect of gossypol on the thyroid in young rats. | 1989 | J. Comp. Pathol. | pmid:2760274 |
| Soufir JC et al. | Gossypol-induced modifications in the microenvironment of rat epididymal spermatozoa. | 1989 | J. Reprod. Fertil. | pmid:2760873 |
| Mohan J et al. | Studies on antifertility effects of gossypol acetic acid in domestic cocks. | 1989 | J. Reprod. Fertil. | pmid:2536813 |
| Alheid U et al. | Human endothelial cells inhibit platelet aggregation by separately stimulating platelet cyclic AMP and cyclic GMP. | 1989 | Eur. J. Pharmacol. | pmid:2546782 |
| Aletor VA | Effect of varying levels of oyster shell on serum constituents and erythrocyte indices in growing chicken fed gossypol-containing Nigerian cottonseed cake. | 1989 | Nahrung | pmid:2628756 |
| Medeiros YS et al. | Gossypol affects the responsiveness of isolated rat myometrium and vas deferens. | 1989 | Braz. J. Med. Biol. Res. | pmid:2638200 |
| Sipkema P et al. | Does the endothelium play a role in flow-dependent constriction? A study in the isolated rabbit femoral artery. | 1989 | Blood Vessels | pmid:2641926 |
| Adlakha RC et al. | Modulation of 4'-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol. | 1989 | Cancer Res. | pmid:2539251 |
| Kanwar U et al. | Gossypol inhibition of Ca++ uptake and Ca++-ATPase in human ejaculated spermatozoal plasma membrane vesicles. | 1989 | Contraception | pmid:2541968 |
| Morgan SE | Gossypol as a toxicant in livestock. | 1989 | Vet. Clin. North Am. Food Anim. Pract. | pmid:2667706 |
| Wu D | An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. | 1989 | Drugs | pmid:2680434 |
| Allamiiarova SA and Urazmetov KG | [The effect of batriden and dexasone on immune status indices in animals with experimental allergic contact dermatitis]. | 1989 | Vestn Dermatol Venerol | pmid:2609756 |
| Han SD et al. | [Study on quality of gossypol recrystalized from chloroform]. | 1989 | Yao Xue Xue Bao | pmid:2609986 |
| Obeidy A et al. | The effect of gossypol on serum lipoproteins of adult rats. | 1989 | Horm. Metab. Res. | pmid:2613178 |
| Deng HL et al. | [The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats]. | 1989 | Yao Xue Xue Bao | pmid:2618689 |
| Wu GP et al. | [Synthesis and antifertility actions of gossypol derivatives and phenol aldehydes]. | 1989 | Yao Xue Xue Bao | pmid:2618691 |
| Lin TS et al. | Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol. | 1989 | Antimicrob. Agents Chemother. | pmid:2619282 |
| Ye YX et al. | Modification of the positive inotropic effects of catecholamines, cardiac glycosides and Ca2+ by the orally active male contraceptive, gossypol, in isolated guinea-pig heart. | 1989 | Life Sci. | pmid:2557505 |
| Haschek WM et al. | Cottonseed meal (gossypol) toxicosis in a swine herd. | 1989 | J. Am. Vet. Med. Assoc. | pmid:2777708 |
| Jimenez DA et al. | Effect of feeding gossypol in cottonseed meal on growth, semen quality, and spermatogenesis of yearling Holstein bulls. | 1989 | J. Dairy Sci. | pmid:2778170 |
| Abou-Donia MB et al. | Interspecies comparison of pharmacokinetic profile and bioavailability of (+/-)-gossypol in male Fischer-344 rats and male B6C3F mice. | 1989 | Toxicology | pmid:2711405 |
| Druez D et al. | Effect of gossypol on the morphology, motility and metabolism of a flagellated protist, Dunaliella bioculata. | 1989 | J. Submicrosc. Cytol. Pathol. | pmid:2752364 |
| Uchijima Y et al. | [Effects of gossypol on human specific lactate dehydrogenase-C4 (LDH-C4)]. | 1989 | Nihon Funin Gakkai Zasshi | pmid:12158558 |
| Katoh N and Kimura K | Inhibition by gossypol of cyclic nucleotide-independent phosvitin kinase from pig testis. | 1989 | Nippon Juigaku Zasshi | pmid:2927017 |