Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Danke RJ and Tillman AD | Effect of free gossypol and supplemental dietary iron on blood constituents of rats. | 1965 | J. Nutr. | pmid:5897732 |
Smith FH and Clawson AJ | Effect of diet on accumulation of gossypol in the organs of swine. | 1965 | J. Nutr. | pmid:5892976 |
Wang YE et al. | [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:583588 |
de Buckle TS et al. | Two food applications of cottonseed flours and meals. | 1979 | J Am Oil Chem Soc | pmid:583421 |
Graham GG et al. | Dietary protein quality in infants and children. II. Metabolic studies with cottonseed flour. | 1969 | Am. J. Clin. Nutr. | pmid:5819114 |
Cherry JP et al. | Potential for improving cottonseed quality by genetic and agronomic practices. | 1978 | Adv. Exp. Med. Biol. | pmid:581532 |
Alford BB and Onley K | The minimum cottonseed protein required for nitrogen balance in women. | 1978 | J. Nutr. | pmid:580097 |
Cornu A et al. | [Utilization of gossypol-free cottonseed and its by-products as human food]. | 1977 | Ann Nutr Aliment | pmid:579293 |
Baugher WL and Campbell TC | Gossypol detoxication by fungi. | 1969 | Science | pmid:5786644 |
Lyman CM et al. | Metabolism of gossypol in the chick. | 1969 | J Am Oil Chem Soc | pmid:5779540 |
Jones LA and Smith FH | Effect of gossypol on the removal of nitrogen and amino acids from feed in digestion by the rat. | 1977 | J. Anim. Sci. | pmid:576597 |
Jones LA and Smith FH | Effect of bound gossypol and amino acid supplementation of glandless cottonseed meal on the growth of weanling rats. | 1977 | J. Anim. Sci. | pmid:576596 |
Albrecht JE et al. | Effects of high gossypol cottonseed meal on the electrocardiogram of swine. | 1968 | J. Anim. Sci. | pmid:5744268 |
Albrecht JE et al. | Effect of initial weight and days on feed on the accumulation of gossypol in pig livers. | 1971 | J. Anim. Sci. | pmid:5546881 |
Buitrago JA et al. | Effects of dietary iron on gossypol accumulation in and elimination from porcine liver. | 1970 | J. Anim. Sci. | pmid:5520345 |
Vichkanova SA et al. | [Antiviral properties of gossypol in experimental influenza pneumonia]. | 1970 | Antibiotiki | pmid:5501368 |
Smith FH and Clawson AJ | The effects of dietary gossypol on animals. | 1970 | J Am Oil Chem Soc | pmid:5487114 |
Abou-Donia MB et al. | Metabolic fate of gossypol: the metabolism of 14C-gossypol in rats. | 1970 | Lipids | pmid:5484207 |
Tone JN and Jensen DR | Effect of ingested gossypol on the growth performance of rats. | 1970 | Experientia | pmid:5478639 |
Mauron J | [Chemical behavior of proteins at the time of preparation of nutrients and their biological effects]. | 1970 | Int Z Vitaminforsch | pmid:5451301 |