Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kim SH et al. | Gossypol, a hyperthermic sensitizer of HeLa cells. | 1985 | Cancer Res. | pmid:4063984 |
Ghittino P et al. | Experimental dietary hepatoma in rainbow trout. The role of cottonseed meals and other diets. | 1967 | Cancro | pmid:4303305 |
Yin J et al. | Novel O-glycosidic gossypol isomers and their bioactivities. | 2011 | Carbohydr. Res. | pmid:21788013 |
Murohara T et al. | Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries. | 1991 | Cardiovasc. Res. | pmid:1806231 |
Senarisoy M et al. | Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks. | 2013 | Cell Biochem. Biophys. | pmid:23161103 |
Kapoor S | Attenuating effect of gossypol on tumor growth in systemic malignancies. | 2013 | Cell Biochem. Biophys. | pmid:23743711 |
Yurtcu E et al. | Apoptotic effect of gossypol on human lymphocytes. | 2003 | Cell Biol. Int. | pmid:12972286 |
Ergun MA et al. | Apoptosis and nitric oxide release induced by thalidomide, gossypol and dexamethasone in cultured human chronic myelogenous leukemic K-562 cells. | 2004 | Cell Biol. Int. | pmid:14984751 |
Ergun U et al. | Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes. | 2005 | Cell Biol. Int. | pmid:15949956 |
Sanli UA et al. | Targeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination. | 2009 | Cell Biol. Int. | pmid:19716895 |
Tres LL et al. | Permeable collagen-glycosaminoglycan cross-linked copolymers for the study of biological responses of cocultured Sertoli and spermatogenic cells. | 1992 Jul-Sep | Cell Biol. Toxicol. | pmid:1446259 |
Hutchinson RW et al. | Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells. | 1998 | Cell Biol. Toxicol. | pmid:9879931 |
Wolter KG et al. | Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins. | 2007 | Cell Death Differ. | pmid:17541428 |
Varadarajan S et al. | A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. | 2012 | Cell Death Differ. | pmid:22955944 |
Goldsmith KC et al. | BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists. | 2010 | Cell Death Differ. | pmid:19893570 |
Lian J et al. | A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. | 2011 | Cell Death Differ. | pmid:20577262 |
Yuan Y et al. | Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. | 2013 | Cell Death Dis | pmid:23807219 |
Cheng P et al. | The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. | 2013 | Cell Death Dis | pmid:23392177 |
Li G et al. | RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. | 2014 | Cell Death Dis | pmid:24434521 |
Goff DJ et al. | A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. | 2013 | Cell Stem Cell | pmid:23333150 |
Bozek SA et al. | Scanning electron microscopic study of spermatozoa from gossypol-treated rats. | 1981 | Cell Tissue Res. | pmid:7273120 |
Nadakavukaren MJ et al. | Effect of gossypol on the ultrastructure of rat spermatozoa. | 1979 | Cell Tissue Res. | pmid:535032 |
Ionov M et al. | The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix. | 2010 | Cell. Mol. Biol. Lett. | pmid:19936629 |
Leyman A et al. | The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts. | 2007 | Cell. Signal. | pmid:17355905 |
Havránek F | [Gossypol, a new contraceptive agent for men]. | 1979 | Cesk Gynekol | pmid:116775 |
Hockenbery D | Breaking down tumor defenses. | 2004 | Chem. Biol. | pmid:15123233 |
Becattini B et al. | Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). | 2004 | Chem. Biol. | pmid:15123268 |
Lu H and Liu GT | Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and anti-oxidative enzyme activity. | 1991 | Chem. Biol. Interact. | pmid:1849050 |
Bhatia C et al. | Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. | 2015 | Chem. Biol. Interact. | pmid:25526675 |
Wood AB et al. | Conformation and hydrogen bonding of gossypol. | 1969 | Chem. Ind. | pmid:5357782 |
ADAMS R et al. | Gossypol, a pigment of cottonseed. | 1960 | Chem. Rev. | pmid:13681414 |
Kilburn KH et al. | Two patterns for bronchial damage from inhaled materials. | 1974 | Chest | pmid:4819236 |
Hu ZY et al. | Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species. | 2011 | Chin J Cancer | pmid:21192843 |
Zhang SD et al. | Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. | 2015 | Chin J Nat Med | pmid:26412425 |
Cheng JS et al. | Effect of gossypol on intracellular Ca2+ regulation in human hepatoma cells. | 2003 | Chin J Physiol | pmid:14672280 |
Chang Q et al. | Drug synergistic antifertility effect of combined administration of low-dose gossypol with steroid hormones in rats. | 2011 | Chin. Med. J. | pmid:21740776 |
Gossypol--a new antifertility agent for males. | 1978 | Chin. Med. J. | pmid:104833 | |
Tong SM et al. | Human antifertility effect of gossypol cytologic observation of semen. | 1982 | Chin. Med. J. | pmid:6216077 |
Zhang Y et al. | Estrogen and progestin cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy. | 1996 | Chin. Med. J. | pmid:9275362 |
Qian SZ et al. | Gossypol related hypokalemia. Clinicopharmacologic studies. | 1980 | Chin. Med. J. | pmid:6772395 |
Ye W et al. | Effect of intra-vas deferens injection of gossypol-polylactic acid on fertility and spermatogenesis in rats. | 1993 | Chin. Med. Sci. J. | pmid:8274715 |
Xiao B and Wang M | Birth control techniques in China. | 1983 | China Popul Newsl | pmid:12312957 |
Han S | New progress in research on contraceptive technology. | 1986 | China Popul Newsl | pmid:12268508 |
Dowd MK | Preparation of enantiomeric gossypol by crystallization. | 2003 | Chirality | pmid:12774287 |
Freedman TB et al. | Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism. | 2003 | Chirality | pmid:12520512 |
Bassenge E et al. | Abluminal release and asymmetrical response of the rabbit arterial wall to endothelium-derived relaxing factor. | 1987 | Circ. Res. | pmid:3117407 |
Pond GR et al. | Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer. | 2012 | Clin Genitourin Cancer | pmid:23000202 |
Stein MN et al. | A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. | 2016 | Clin Genitourin Cancer | pmid:26476589 |
Hall C et al. | Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. | 2013 | Clin Genitourin Cancer | pmid:23083798 |
Henderson J et al. | Occupation-related male infertility: a review. | 1986 | Clin Reprod Fertil | pmid:3527400 |
Oliver CL et al. | In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. | 2004 | Clin. Cancer Res. | pmid:15570010 |
Kang MH and Reynolds CP | Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. | 2009 | Clin. Cancer Res. | pmid:19228717 |
Liu G et al. | An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. | 2009 | Clin. Cancer Res. | pmid:19366825 |
Sheriff DS et al. | Effect of gossypol on the activity of erythrocyte Na+-K+ ATPase activity in vitro. | 1987 | Clin. Chem. | pmid:3026686 |
Jiang J et al. | Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling. | 2012 | Clin. Exp. Metastasis | pmid:22167622 |
Zhang M et al. | Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. | 2007 | Clin. Exp. Pharmacol. Physiol. | pmid:17250644 |
Chang JS et al. | Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15554914 |
Wu DF et al. | Pharmacokinetics of (+/-)-, (+)-, and (-)-gossypol in humans and dogs. | 1986 | Clin. Pharmacol. Ther. | pmid:3709025 |
Prakash O and Khan F | Development of method for three-point data estimation and SVR-QSAR model to screen anti cancer leads. | 2013 | Comb. Chem. High Throughput Screen. | pmid:23410041 |
Kim HL et al. | Accumulation of gossypol enantiomers in ovine tissues. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8653593 |
MartÃnez F | The antifertility agent, gossypol, changes several mitochondrial functions in the presence of Mg2+. | 1992 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:1360378 |
MartÃnez F et al. | The antifertility agent, gossypol, releases calcium from rat liver mitochondria. | 1993 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:8097449 |
Trischitta F and Faggio C | Gossypol affects ion transport in the isolated intestine of the seawater adapted eel, Anguilla anguilla. | 2008 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:18606239 |
Velez de la Calle JF and Bujan L | [Male contraception]. | 1995 | Contracept Fertil Sex | pmid:7613573 |
Udoh P et al. | Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats. | 1992 | Contraception | pmid:1623720 |
Udoh P and Patil DR | Effects of gossypol acetate on pituitary-adrenal axis in male albino rats. | 1992 | Contraception | pmid:1324828 |
Duo X et al. | Clinical safety of long-term administration of gossypol in 32 cases. | 1988 | Contraception | pmid:3370987 |
van Ypersele de Strihou C et al. | Effects of gossypol on the kidney with special emphasis on potassium (K) excretion. | 1988 | Contraception | pmid:3370990 |
Heywood R | The toxicology of gossypol acetic acid and (-)-gossypol. | 1988 | Contraception | pmid:3370991 |
Wang RL et al. | Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships. | 1988 | Contraception | pmid:3370992 |
Pearce S et al. | Inhibition by gossypol of cyclic AMP production in mouse Leydig cells. | 1986 | Contraception | pmid:3030630 |
Tang F et al. | Inhibition of catechol-O-methyltransferase by gossypol: the effect of plasma proteins. | 1982 | Contraception | pmid:7160182 |
Meng GD et al. | Follow-up of men in the recovery period immediately after the cessation of gossypol treatment. | 1988 | Contraception | pmid:3131064 |
Bourinbaiar AS and Lee-Huang S | Comparative in vitro study of contraceptive agents with anti-HIV activity: gramicidin, nonoxynol-9, and gossypol. | 1994 | Contraception | pmid:7511493 |
Waller DP et al. | In vitjro spermicidal activity of gossypol. | 1980 | Contraception | pmid:7449381 |
Ueno H et al. | Interaction of gossypol with sperm macromolecules and enzymes. | 1988 | Contraception | pmid:2967157 |
Coutinho EM et al. | Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive. A multicenter, international, dose-finding study. | 2000 | Contraception | pmid:10745071 |
Wichmann K et al. | Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism. | 1986 | Contraception | pmid:3757514 |
Kainz P et al. | Effect of gossypol on macromolecular synthesis in rat testis. An in vitro study. | 1985 | Contraception | pmid:2580663 |
Stumpf WE et al. | Sites of action of gossypol studied by autoradiography and enzyme histochemistry. | 1988 | Contraception | pmid:3370998 |
Fei RR and Teng CS | The effects of gossypol on nuclear protein in rat testes. I. Reduction in the content of basic proteins in the spermiogenic cells. | 1988 | Contraception | pmid:3370999 |
Johansen RL and Misra HP | Effects of gossypol on the hepatic drug metabolizing system in rats. | 1990 | Contraception | pmid:2083490 |
Teng CS and Fei RR | The effects of gossypol on nuclear protein in rat testes. II. The synthesis of histones and testis-specific proteins after gossypol treatment. | 1988 | Contraception | pmid:3371000 |
Hoffer AP et al. | Antifertility, spermicidal and ultrastructural effects of gossypol and derivatives administered orally and by intratesticular injections. | 1988 | Contraception | pmid:3371001 |
Lin YC et al. | Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats. | 1987 | Contraception | pmid:3447817 |
Kim IC et al. | Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone. | 1984 | Contraception | pmid:6509980 |
Cui GH et al. | A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats. | 2004 | Contraception | pmid:15451339 |
Kalla NR et al. | Involvement of prostaglandin in the antifertility effects of gossypol. | 1986 | Contraception | pmid:3465506 |
Kanwar U et al. | Gossypol-induced inhibition of glucose uptake in human ejaculated spermatozoa may be mediated by lipid peroxidation. | 1990 | Contraception | pmid:2272185 |
Kanwar U et al. | Gossypol inhibition of Ca++ uptake and Ca++-ATPase in human ejaculated spermatozoal plasma membrane vesicles. | 1989 | Contraception | pmid:2541968 |
Chongthammakun S et al. | Effects of gossypol on human and monkey sperm motility in vitro. | 1986 | Contraception | pmid:3791997 |
Wu D and Reidenberg MM | Effect of potassium deficiency and gossypol on urinary N-acetyl-beta-glucosaminidase excretion in the rat. | 1993 | Contraception | pmid:8275698 |
Teng CS | Gossypol-induced apoptotic DNA fragmentation correlates with inhibited protein kinase C activity in spermatocytes. | 1995 | Contraception | pmid:8749604 |
Teng CS et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. VI. Alteration in nuclear factors for interaction with histone gene promoter. | 1995 | Contraception | pmid:8536450 |
Matlin SA et al. | (-)-Gossypol: an active male antifertility agent. | 1985 | Contraception | pmid:3987276 |
Sufi SB et al. | Inhibition by (+) and (-) isomers of gossypol of testosterone release from mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987277 |
Donaldson A et al. | Inhibition by gossypol of testosterone production by mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987278 |
Wong PY et al. | Lack of an effect of gossypol on the epididymis of the rat. | 1983 | Contraception | pmid:6851567 |
Giridharan N et al. | Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats. | 1987 | Contraception | pmid:3568662 |
Coutinho EM and Melo JF | Clinical experience with gossypol in non-Chinese men: a follow-up. | 1988 | Contraception | pmid:3286112 |