Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: III. The activity for the transcription of messenger RNA. | 1992 | Contraception | pmid:1559338 |
Udoh P et al. | Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats. | 1992 | Contraception | pmid:1623720 |
Udoh P and Patil DR | Effects of gossypol acetate on pituitary-adrenal axis in male albino rats. | 1992 | Contraception | pmid:1324828 |
Fu YF et al. | Effects of gossypol on the activity of kidney (Na+ + K+)-ATPase and the functions of erythrocyte membrane. | 1988 | Contraception | pmid:2836126 |
White IG et al. | Studies of the mechanism of action of gossypol as a male antifertility agent. | 1988 | Contraception | pmid:2836127 |
Duo X et al. | Clinical safety of long-term administration of gossypol in 32 cases. | 1988 | Contraception | pmid:3370987 |
van Ypersele de Strihou C et al. | Effects of gossypol on the kidney with special emphasis on potassium (K) excretion. | 1988 | Contraception | pmid:3370990 |
Heywood R | The toxicology of gossypol acetic acid and (-)-gossypol. | 1988 | Contraception | pmid:3370991 |
Wang RL et al. | Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships. | 1988 | Contraception | pmid:3370992 |
Pearce S et al. | Inhibition by gossypol of cyclic AMP production in mouse Leydig cells. | 1986 | Contraception | pmid:3030630 |
Sakesena SK et al. | Gossypol: its toxicological and endocrinological effects in male rabbits. | 1981 | Contraception | pmid:7297071 |
Tso WW and Lee CS | Variations of gossypol sensitivity in boar spermatozoal electron transport chain segments. | 1981 | Contraception | pmid:7318437 |
Bourinbaiar AS and Lee-Huang S | Comparative in vitro study of contraceptive agents with anti-HIV activity: gramicidin, nonoxynol-9, and gossypol. | 1994 | Contraception | pmid:7511493 |
Waller DP et al. | In vitjro spermicidal activity of gossypol. | 1980 | Contraception | pmid:7449381 |
Whaley KJ et al. | Monkey lactate dehydrogenase-C4 as a model for the interaction of enzymes with gossypol. | 1986 | Contraception | pmid:3769483 |
Ojha P et al. | Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. | 2006 | Contraception | pmid:16371305 |
Ueno H et al. | Interaction of gossypol with sperm macromolecules and enzymes. | 1988 | Contraception | pmid:2967157 |
Coutinho EM et al. | Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive. A multicenter, international, dose-finding study. | 2000 | Contraception | pmid:10745071 |
Ma XN and Back DJ | Inhibition of hepatic microsomal enzymes by gossypol in the rat. | 1984 | Contraception | pmid:6478834 |
Kainz P et al. | Effect of gossypol on macromolecular synthesis in rat testis. An in vitro study. | 1985 | Contraception | pmid:2580663 |
Xue SP et al. | Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. | 1988 | Contraception | pmid:3370989 |
Beaudoin AR | A developmental toxicity evaluation of gossypol. | 1988 | Contraception | pmid:3370993 |
Benz C et al. | Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy. | 1988 | Contraception | pmid:3370994 |
Matlin SA et al. | Large-scale resolution of gossypol enantiomers for biological evaluation. | 1988 | Contraception | pmid:3370995 |
Zhou RH and Lin XD | Isolation of (-)-gossypol from natural plant. | 1988 | Contraception | pmid:3370996 |
Sonenberg M et al. | Anti-fertility and other actions of gossypol analogues. | 1988 | Contraception | pmid:3370997 |
Stumpf WE et al. | Sites of action of gossypol studied by autoradiography and enzyme histochemistry. | 1988 | Contraception | pmid:3370998 |
Ratsula K et al. | Vaginal contraception with gossypol: a clinical study. | 1983 | Contraception | pmid:6684533 |
Fei RR and Teng CS | The effects of gossypol on nuclear protein in rat testes. I. Reduction in the content of basic proteins in the spermiogenic cells. | 1988 | Contraception | pmid:3370999 |
Teng CS and Fei RR | The effects of gossypol on nuclear protein in rat testes. II. The synthesis of histones and testis-specific proteins after gossypol treatment. | 1988 | Contraception | pmid:3371000 |
Hoffer AP et al. | Antifertility, spermicidal and ultrastructural effects of gossypol and derivatives administered orally and by intratesticular injections. | 1988 | Contraception | pmid:3371001 |
Lin YC et al. | Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats. | 1987 | Contraception | pmid:3447817 |
Cui GH et al. | A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats. | 2004 | Contraception | pmid:15451339 |
Kumar M et al. | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. | 1997 | Contraception | pmid:9408707 |
Lin YC et al. | Effect of gossypol on thyroid hormones in young female rats. | 1990 | Contraception | pmid:2335106 |
Kanwar U et al. | Gossypol-induced inhibition of glucose uptake in human ejaculated spermatozoa may be mediated by lipid peroxidation. | 1990 | Contraception | pmid:2272185 |
Sinha Hikim AP and Hoffer AP | Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol. | 1987 | Contraception | pmid:3621939 |
Bansode FW | Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia). | 1994 | Contraception | pmid:8070265 |
Polsky B et al. | Inactivation of human immunodeficiency virus in vitro by gossypol. | 1989 | Contraception | pmid:2473865 |
González-Garza MT et al. | Orally administered gossypol has no effect on eight hamster erythrocytic enzymes. | 1995 | Contraception | pmid:8749602 |
Teng CS | Gossypol-induced apoptotic DNA fragmentation correlates with inhibited protein kinase C activity in spermatocytes. | 1995 | Contraception | pmid:8749604 |
Wang C and Yeung RT | Gossypol and hypokalaemia. | 1985 | Contraception | pmid:3910352 |
Yuan YY and Shi QX | Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity. | 2000 | Contraception | pmid:11137075 |
Matlin SA et al. | (-)-Gossypol: an active male antifertility agent. | 1985 | Contraception | pmid:3987276 |
Sufi SB et al. | Inhibition by (+) and (-) isomers of gossypol of testosterone release from mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987277 |
Donaldson A et al. | Inhibition by gossypol of testosterone production by mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987278 |
Wong PY et al. | Lack of an effect of gossypol on the epididymis of the rat. | 1983 | Contraception | pmid:6851567 |
Giridharan N et al. | Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats. | 1987 | Contraception | pmid:3568662 |
Coutinho EM | Gossypol: a contraceptive for men. | 2002 | Contraception | pmid:12020773 |
Coutinho EM and Melo JF | Clinical experience with gossypol in non-Chinese men: a follow-up. | 1988 | Contraception | pmid:3286112 |