Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Shaaban WF et al. | Reproductive toxicologic effects of gossypol on male rabbits: biochemical, enzymatic, and electrolytic properties of seminal plasma. | 2008 | Fertil. Steril. | pmid:17953964 |
Lin T et al. | Gossypol inhibits testicular steroidogenesis. | 1981 | Fertil. Steril. | pmid:7194804 |
Cameron SM et al. | Vaginal spermicidal activity of gossypol in the Macaca arctoides. | 1982 | Fertil. Steril. | pmid:7060775 |
Saksena SK and Salmonsen RA | Antifertility effects of gossypol in male hamsters. | 1982 | Fertil. Steril. | pmid:7075801 |
Coutinho EM et al. | Antispermatogenic action of gossypol in men. | 1984 | Fertil. Steril. | pmid:6468676 |
Pankajakshy A and Madambath I | Spermatotoxic effects of Cananga odorata (Lam): a comparison with gossypol. | 2009 | Fertil. Steril. | pmid:18692834 |
Ridley AJ and Blasco L | Testosterone and gossypol effects on human sperm motility. | 1981 | Fertil. Steril. | pmid:6273239 |
Liu GZ et al. | Clinical trial of gossypol as a male contraceptive drug. Part I. Efficacy study. | 1987 | Fertil. Steril. | pmid:3305087 |
Cowart CL et al. | The effects of cyclic adenosine monophosphate, forskolin, and theophylline on motility parameters in gossypol-treated human sperm. | 1994 | Fertil. Steril. | pmid:8174733 |
Liu GZ and Lyle KC | Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study. | 1987 | Fertil. Steril. | pmid:3305088 |
Smith C et al. | Protection by albumin against the pro-oxidant actions of phenolic dietary components. | 1992 | Food Chem. Toxicol. | pmid:1379971 |
Jo C et al. | Irradiation effects on embryotoxicity and oxidative properties of gossypol dissolved in methanol. | 2003 | Food Chem. Toxicol. | pmid:12909266 |
Moon DO et al. | Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity. | 2011 | Food Chem. Toxicol. | pmid:21223991 |
Fonseca NB et al. | Effectiveness of albumin-conjugated gossypol as an immunogen to prevent gossypol-associated acute hepatotoxicity in rats. | 2013 | Food Chem. Toxicol. | pmid:23485613 |
El-Sharaky AS et al. | Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. | 2009 | Food Chem. Toxicol. | pmid:19665044 |
El-Sharaky AS et al. | Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats. | 2010 | Food Chem. Toxicol. | pmid:20832445 |
EAGLE E and BIALEK HF | Effect of single and repeated doses of gossypol on the rat. | 1950 May-Jun | Food Res | pmid:15427706 |
Li AS et al. | DNA-breaking versus DNA-protecting activity of four phenolic compounds in vitro. | 2000 | Free Radic. Res. | pmid:11200088 |
Liu YX | Temperature control of spermatogenesis and prospect of male contraception. | 2010 | Front Biosci (Schol Ed) | pmid:20036980 |
Barhoumi R et al. | Alteration of oxytocin-induced calcium oscillations in clone 9 cells by toxin exposure. | 1996 | Fundam Appl Toxicol | pmid:8921340 |
Ye YX et al. | The modulation of gap junctional communication by gossypol in various mammalian cell lines in vitro. | 1990 | Fundam Appl Toxicol | pmid:2361580 |
Barhoumi R and Burghardt RC | Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro. | 1996 | Fundam Appl Toxicol | pmid:8812278 |
Granchi C et al. | Small-molecule inhibitors of human LDH5. | 2013 | Future Med Chem | pmid:24175747 |
Baccetti B et al. | Action of gossypol on rat germinal cells. II. The acrosome. | 1987 | Gamete Res | pmid:3506897 |
Miranda FJ et al. | Endothelial modulation of 5-hydroxytryptamine-induced contraction in goat cerebral arteries. | 1993 | Gen. Pharmacol. | pmid:8365646 |
Messiha FS | Effect of gossypol on kinetics of mouse liver alcohol and aldehyde dehydrogenase. | 1991 | Gen. Pharmacol. | pmid:1936890 |
Gupta GS and Kang BP | Quenching of intrinsic fluorescence of sperm specific LDH by optical isomers of gossypol. | 1997 | Gen. Physiol. Biophys. | pmid:9452944 |
Wu Y et al. | Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1. | 2015 | Genet. Mol. Res. | pmid:26535659 |
Lee J | The inheritance of gossypol level in Gossypium. II. Inheritance of seed gosypol in two trains of cultivated Gossypoium barbadense L. | 1973 | Genetics | pmid:4769299 |
Zakhidov ST et al. | [Cytogenetic study of the effect of gossypol on mouse germ cells]. | 1987 | Genetika | pmid:3623090 |
Muratov MM et al. | [Hygienic evaluation of acetate fabric dyed with technical grade gossypol]. | 1980 | Gig Sanit | pmid:7372107 |
Frick J et al. | [A pill for the man? Current status of fertility control in the man]. | 1998 | Gynakol Geburtshilfliche Rundsch | pmid:9658718 |
Gossypol--a new antifertility agent for males. | 1979 | Gynecol. Obstet. Invest. | pmid:393575 | |
Band V et al. | Antiproliferative effect of gossypol and its optical isomers on human reproductive cancer cell lines. | 1989 | Gynecol. Oncol. | pmid:2920946 |
Glander HJ | [Comments on reversible nonhormonal contraception in the male]. | 1987 | Hautarzt | pmid:3654202 |
Bialy G and Alexander NJ | Developments in male contraception. | 1992 | Health Sex | pmid:12286189 |
Sahin F et al. | Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity. | 2010 | Hematology | pmid:20557672 |
Baba Y | [Effect of HCG administration in the gossypol-treated male rats]. | 1988 | Hinyokika Kiyo | pmid:3135706 |
Obeidy A et al. | The effect of gossypol on serum lipoproteins of adult rats. | 1989 | Horm. Metab. Res. | pmid:2613178 |
Sheriff DS | Gossypol and testicular lipids of adult rats. | 1988 | Horm. Metab. Res. | pmid:3215629 |
Nakamura M et al. | Presence of a 16 kd protein in human seminal plasma counteracts the effects of the anti-fertility agent, gossypol. | 1991 | Hum. Reprod. | pmid:1939555 |
Cleverley J | American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA. | 2006 | IDrugs | pmid:16871453 |
Barba-Barajas M et al. | Gossypol induced apoptosis of polymorphonuclear leukocytes and monocytes: involvement of mitochondrial pathway and reactive oxygen species. | 2009 | Immunopharmacol Immunotoxicol | pmid:19235535 |
Song B et al. | Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways. | 2013 | Immunopharmacol Immunotoxicol | pmid:23981004 |
Ye WS et al. | Toxicity of a male contraceptive, gossypol, in mammalian cell cultures. | 1983 | In Vitro | pmid:6185412 |
Hu F et al. | Gossypol effects on cultured normal and malignant melanocytes. | 1986 | In Vitro Cell. Dev. Biol. | pmid:3771439 |
Rao AG | A stoichiometric analysis of bovine serum albumin-gossypol interactions: a fluorescence quenching study. | 1992 | Indian J. Biochem. Biophys. | pmid:1398710 |
Mazumder B et al. | Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes. | 1991 | Indian J. Biochem. Biophys. | pmid:1831790 |
Reddy RM et al. | Pattern of ovarian and uterine carbohydrate metabolism during induced antiimplantation by (+)gossypol. | 1984 | Indian J. Exp. Biol. | pmid:6510968 |
Achudume AC et al. | Experimental analysis of gossypol and chloroquine interaction in serum and in liver of rat. | 1998 | Indian J. Exp. Biol. | pmid:10356961 |