Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: III. The activity for the transcription of messenger RNA. | 1992 | Contraception | pmid:1559338 |
| Udoh P et al. | Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats. | 1992 | Contraception | pmid:1623720 |
| Udoh P and Patil DR | Effects of gossypol acetate on pituitary-adrenal axis in male albino rats. | 1992 | Contraception | pmid:1324828 |
| Lan ZJ et al. | Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells. | 1992 | Contraception | pmid:1511610 |
| Duo X et al. | Clinical safety of long-term administration of gossypol in 32 cases. | 1988 | Contraception | pmid:3370987 |
| van Ypersele de Strihou C et al. | Effects of gossypol on the kidney with special emphasis on potassium (K) excretion. | 1988 | Contraception | pmid:3370990 |
| Heywood R | The toxicology of gossypol acetic acid and (-)-gossypol. | 1988 | Contraception | pmid:3370991 |
| Wang RL et al. | Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships. | 1988 | Contraception | pmid:3370992 |
| Pearce S et al. | Inhibition by gossypol of cyclic AMP production in mouse Leydig cells. | 1986 | Contraception | pmid:3030630 |
| Tang F et al. | Inhibition of catechol-O-methyltransferase by gossypol: the effect of plasma proteins. | 1982 | Contraception | pmid:7160182 |
| Meng GD et al. | Follow-up of men in the recovery period immediately after the cessation of gossypol treatment. | 1988 | Contraception | pmid:3131064 |
| Bourinbaiar AS and Lee-Huang S | Comparative in vitro study of contraceptive agents with anti-HIV activity: gramicidin, nonoxynol-9, and gossypol. | 1994 | Contraception | pmid:7511493 |
| Waller DP et al. | In vitjro spermicidal activity of gossypol. | 1980 | Contraception | pmid:7449381 |
| Whaley KJ et al. | Monkey lactate dehydrogenase-C4 as a model for the interaction of enzymes with gossypol. | 1986 | Contraception | pmid:3769483 |
| Ueno H et al. | Interaction of gossypol with sperm macromolecules and enzymes. | 1988 | Contraception | pmid:2967157 |
| Coutinho EM et al. | Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive. A multicenter, international, dose-finding study. | 2000 | Contraception | pmid:10745071 |
| Wichmann K et al. | Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism. | 1986 | Contraception | pmid:3757514 |
| Ma XN and Back DJ | Inhibition of hepatic microsomal enzymes by gossypol in the rat. | 1984 | Contraception | pmid:6478834 |
| Kainz P et al. | Effect of gossypol on macromolecular synthesis in rat testis. An in vitro study. | 1985 | Contraception | pmid:2580663 |
| Matlin SA et al. | Large-scale resolution of gossypol enantiomers for biological evaluation. | 1988 | Contraception | pmid:3370995 |
| Zhou RH and Lin XD | Isolation of (-)-gossypol from natural plant. | 1988 | Contraception | pmid:3370996 |
| Sonenberg M et al. | Anti-fertility and other actions of gossypol analogues. | 1988 | Contraception | pmid:3370997 |
| Stumpf WE et al. | Sites of action of gossypol studied by autoradiography and enzyme histochemistry. | 1988 | Contraception | pmid:3370998 |
| Fei RR and Teng CS | The effects of gossypol on nuclear protein in rat testes. I. Reduction in the content of basic proteins in the spermiogenic cells. | 1988 | Contraception | pmid:3370999 |
| Johansen RL and Misra HP | Effects of gossypol on the hepatic drug metabolizing system in rats. | 1990 | Contraception | pmid:2083490 |
| Teng CS and Fei RR | The effects of gossypol on nuclear protein in rat testes. II. The synthesis of histones and testis-specific proteins after gossypol treatment. | 1988 | Contraception | pmid:3371000 |
| Hoffer AP et al. | Antifertility, spermicidal and ultrastructural effects of gossypol and derivatives administered orally and by intratesticular injections. | 1988 | Contraception | pmid:3371001 |
| Lin YC et al. | Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats. | 1987 | Contraception | pmid:3447817 |
| Kim IC et al. | Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone. | 1984 | Contraception | pmid:6509980 |
| Cui GH et al. | A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats. | 2004 | Contraception | pmid:15451339 |
| Kalla NR et al. | Involvement of prostaglandin in the antifertility effects of gossypol. | 1986 | Contraception | pmid:3465506 |
| Kanwar U et al. | Gossypol-induced inhibition of glucose uptake in human ejaculated spermatozoa may be mediated by lipid peroxidation. | 1990 | Contraception | pmid:2272185 |
| Kanwar U et al. | Gossypol inhibition of Ca++ uptake and Ca++-ATPase in human ejaculated spermatozoal plasma membrane vesicles. | 1989 | Contraception | pmid:2541968 |
| Chongthammakun S et al. | Effects of gossypol on human and monkey sperm motility in vitro. | 1986 | Contraception | pmid:3791997 |
| Wu D and Reidenberg MM | Effect of potassium deficiency and gossypol on urinary N-acetyl-beta-glucosaminidase excretion in the rat. | 1993 | Contraception | pmid:8275698 |
| Bansode FW | Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia). | 1994 | Contraception | pmid:8070265 |
| González-Garza MT et al. | Orally administered gossypol has no effect on eight hamster erythrocytic enzymes. | 1995 | Contraception | pmid:8749602 |
| Teng CS | Gossypol-induced apoptotic DNA fragmentation correlates with inhibited protein kinase C activity in spermatocytes. | 1995 | Contraception | pmid:8749604 |
| Teng CS et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. VI. Alteration in nuclear factors for interaction with histone gene promoter. | 1995 | Contraception | pmid:8536450 |
| Yuan YY and Shi QX | Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity. | 2000 | Contraception | pmid:11137075 |
| Matlin SA et al. | (-)-Gossypol: an active male antifertility agent. | 1985 | Contraception | pmid:3987276 |
| Sufi SB et al. | Inhibition by (+) and (-) isomers of gossypol of testosterone release from mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987277 |
| Donaldson A et al. | Inhibition by gossypol of testosterone production by mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987278 |
| Wong PY et al. | Lack of an effect of gossypol on the epididymis of the rat. | 1983 | Contraception | pmid:6851567 |
| Giridharan N et al. | Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats. | 1987 | Contraception | pmid:3568662 |
| Coutinho EM | Gossypol: a contraceptive for men. | 2002 | Contraception | pmid:12020773 |
| Coutinho EM and Melo JF | Clinical experience with gossypol in non-Chinese men: a follow-up. | 1988 | Contraception | pmid:3286112 |
| Velez de la Calle JF and Bujan L | [Male contraception]. | 1995 | Contracept Fertil Sex | pmid:7613573 |
| Trischitta F and Faggio C | Gossypol affects ion transport in the isolated intestine of the seawater adapted eel, Anguilla anguilla. | 2008 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:18606239 |
| MartÃnez F | The antifertility agent, gossypol, changes several mitochondrial functions in the presence of Mg2+. | 1992 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:1360378 |