Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tazulakhova EB et al. | [Effect of low-molecular interferon inducers in experimental hepatitis in mice]. | 1988 Mar-Apr | Vopr. Virusol. | pmid:2457987 |
pmid:24555821 | ||||
Dudel C and Förstermann U | Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo. | 1988 | Eur. J. Pharmacol. | pmid:2450761 |
Förstermann U et al. | Endothelium-derived relaxing factor is likely to modulate the tone of resistance arteries in rabbit hindlimb in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2447263 |
Paulus A et al. | The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs. | 2014 | Br. J. Haematol. | pmid:24467634 |
Alheid U et al. | Selective inhibition by gossypol of endothelium-dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery. | 1987 | Br. J. Pharmacol. | pmid:2444300 |
Li G et al. | RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. | 2014 | Cell Death Dis | pmid:24434521 |
pmid:24428132 | ||||
Etindi RN and Rillema JA | Effect of kinase C inhibitor, gossypol, on the actions of prolactin in cultured mouse mammary tissues. | 1987 | Biochim. Biophys. Acta | pmid:2434140 |
Sokolova TM et al. | Ridostin induces transcription of a wide spectrum of interferon genes in human cells. | 2013 | Bull. Exp. Biol. Med. | pmid:24319751 |
Mei H et al. | Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer. | 2014 | Neoplasma | pmid:24299314 |
Sonpavde G et al. | Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer. | 2014 | BJU Int. | pmid:24298897 |
Ershov FI et al. | [A new interferon inducer active via peroral administration]. | 1986 May-Jun | Vopr. Virusol. | pmid:2429451 |
Kogan P and Wald M | Male contraception: history and development. | 2014 | Urol. Clin. North Am. | pmid:24286773 |
Ignatova M et al. | Quaternized chitosan-coated nanofibrous implants loaded with gossypol prepared by electrospinning and their efficacy against Graffi myeloid tumor. | 2014 | J Biomater Sci Polym Ed | pmid:24236801 |
Paulus A et al. | AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia. | 2014 | Br. J. Haematol. | pmid:24236538 |
Kanje M et al. | The effect of gossypol on fast axonal transport and microtubule assembly. | 1986 | Biochim. Biophys. Acta | pmid:2421770 |
Haider SG et al. | Reversible changes in rat spermatogenesis induced by an antifertility substance (Gossypol). A histochemical report. | 1985 | Acta Histochem. | pmid:2420139 |
Kainz P et al. | The in vivo effect of gossypol on macromolecular synthesis in rat testis. | 1985 | Contraception | pmid:2419026 |
Granchi C et al. | Small-molecule inhibitors of human LDH5. | 2013 | Future Med Chem | pmid:24175747 |
Lima Pde M et al. | Methane emission of Santa Inês sheep fed cottonseed by-products containing different levels of gossypol. | 2014 | Trop Anim Health Prod | pmid:24132456 |
Zhang Z et al. | Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking. | 2013 | Eur J Med Chem | pmid:24095762 |
Krasil'nikov OV et al. | [Dependence of the protonophore and channel-forming capacity of gossypol on the pH]. | 1985 | Dokl. Akad. Nauk SSSR | pmid:2408838 |
Keshmiri-Neghab H and Goliaei B | Therapeutic potential of gossypol: an overview. | 2014 | Pharm Biol | pmid:24073600 |
Gao W et al. | Proteomic and virus-induced gene silencing (VIGS) Analyses reveal that gossypol, brassinosteroids, and jasmonic acid contribute to the resistance of cotton to Verticillium dahliae. | 2013 | Mol. Cell Proteomics | pmid:24019146 |
Song B et al. | Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways. | 2013 | Immunopharmacol Immunotoxicol | pmid:23981004 |
Jiao X et al. | Comparative transcriptomic analysis of developing cotton cotyledons and embryo axis. | 2013 | PLoS ONE | pmid:23977137 |
Billard C | BH3 mimetics: status of the field and new developments. | 2013 | Mol. Cancer Ther. | pmid:23974697 |
Messiha FS | Gossypol modulation of mouse heart and liver lactate dehydrogenase isoenzymes as a function of gender. | 1990 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2396051 |
Aletor VA and Aturamu OA | Use of oyster shell as calcium supplement. Part 2. An assessment of the responses of hepatic and serum enzymes, relative organ weights, and bone mineralization in the broiler chicken fed gossypol-containing cottonseed cake supplemented with oyster shell. | 1990 | Nahrung | pmid:2388685 |
Aletor VA and Onibi OE | Use of oyster shell as calcium supplement. Part 1. Effect on the utilization of gossypol-containing cotton seed cake by the chicken. | 1990 | Nahrung | pmid:2388684 |
Guo JY et al. | Effects of high-gossypol cotton on the development and reproduction of Bemisia tabaci (Hemiptera: Aleyrodidae) MEAM1 cryptic species. | 2013 | J. Econ. Entomol. | pmid:23865205 |
Schelman WR et al. | A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer. | 2014 | Invest New Drugs | pmid:23860642 |
Deng S et al. | Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. | 2013 | J. Vet. Sci. | pmid:23820203 |
Yuan Y et al. | Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. | 2013 | Cell Death Dis | pmid:23807219 |
Zhou M et al. | Metabolic engineering of gossypol in cotton. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23775273 |
Botsoglou NA and Kufidis DC | Determination of total gossypol in cottonseed and cottonseed meals by derivative UV spectrophotometry. | 1990 May-Jun | J Assoc Off Anal Chem | pmid:2376551 |
Kapoor S | Attenuating effect of gossypol on tumor growth in systemic malignancies. | 2013 | Cell Biochem. Biophys. | pmid:23743711 |
Lin YL et al. | Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells. | 2013 | Mol. Pharm. | pmid:23734725 |
Rikihisa Y et al. | Taenia taeniaeformis: inactivation of metacestodes by gossypol in vitro. | 1990 | Exp. Parasitol. | pmid:2373186 |
Huang T et al. | Gossypol-induced alterations of aminophospholipid composition in human sperm. | 1990 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2371261 |
Lin J et al. | Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. | 2013 | Oncol. Rep. | pmid:23708869 |
Zhan YH et al. | Growth inhibition and apoptosis induction of human umbilical vein endothelial cells by apogossypolone. | 2013 | Asian Pac. J. Cancer Prev. | pmid:23679275 |
Soderquist R et al. | Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. | 2013 | Leukemia | pmid:23640104 |
Pelosin JM et al. | Differential inhibition of protein kinase C subtypes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2363714 |
Varadarajan S et al. | Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. | 2013 | Neoplasia | pmid:23633928 |
Ye YX et al. | The modulation of gap junctional communication by gossypol in various mammalian cell lines in vitro. | 1990 | Fundam Appl Toxicol | pmid:2361580 |
Mellon JE et al. | Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi. | 2013 | J. Appl. Microbiol. | pmid:23594138 |
Zelaya CA et al. | Di(phenylpropylamino)gossypol: a derivative of the dimeric natural product gossypol. | 2013 | Acta Crystallogr C | pmid:23579723 |
Tang H et al. | Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones. | 2013 | PLoS ONE | pmid:23555724 |