Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gu Y and Lin YC | Suppression of adrenocorticotropic hormone (ACTH)-induced corticosterone secretion in cultured rat adrenocortical cells by gossypol and gossypolone. | 1991 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1647048 |
Moh PP et al. | Characteristics of covalent gossypol binding to microsomal proteins. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1636054 |
Messiha FS | Gossypol modulation of mouse heart and liver lactate dehydrogenase isoenzymes as a function of gender. | 1990 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2396051 |
Chang WY et al. | Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8827831 |
Mushtaq M et al. | Gossypol inhibits human chorionic gonadotropin-stimulated testosterone production by cultured canine testicular interstitial cells. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8829766 |
Abou-Donia MB | Physiological effects and metabolism of gossypol. | 1976 | Residue Rev | pmid:778955 |
Demoulin A | [Male contraception]. | 1984 | Rev Med Liege | pmid:6729295 |
Jackson H and Schnieden H | Aspects of male reproductive pharmacology and toxicology. | 1982 Jan-Mar | Rev Pure Appl Pharmacol Sci | pmid:6291102 |
Nogueda-Torres B et al. | Trypanocidal activity of 4 isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi. | 2001 Jan-Mar | Rev. Latinoam. Microbiol. | pmid:17061565 |
Vershinina MY et al. | Regulation of cytokine mRNAs by interferon and interferon inducers. | 2002 | Russ. J. Immunol. | pmid:12687259 |
Räsänen TL et al. | Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase. | 2003 | Scand. J. Gastroenterol. | pmid:12889567 |
Wu G et al. | Temporal allocation of metabolic tolerance in the body of beet armyworm in response to three gossypol-cotton cultivars. | 2009 | Sci. China, C, Life Sci. | pmid:20016971 |
Bi XF et al. | The effect of gossypol on ATPase activity of the kidney. | 1981 | Sci. Sin. | pmid:6266011 |
Shepu X et al. | Antispermatogenic effect of gossypol on the germinal epithelium of the rat testes. A cytological, autoradiographical and ultrastructural observation. | 1980 | Sci. Sin. | pmid:7403840 |
Wu YW et al. | Effect of gossypol on the potential difference of rat seminiferous tubules. | 1985 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:4012264 |
Xue SP et al. | Subcellular site of antispermatogenic effect of gossypol and its possible molecular mechanism of action. | 1983 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:6623054 |
Fishbein L | Natural non-nutrient substances in the food chain. | 1972 | Sci. Total Environ. | pmid:4121147 |
Montamat EE et al. | Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. | 1982 | Science | pmid:6750791 |
Baugher WL and Campbell TC | Gossypol detoxication by fungi. | 1969 | Science | pmid:5786644 |
Eagle E | Chronic Toxicity of Gossypol. | 1949 | Science | pmid:17742136 |