Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kulagin VI and Butov IuS | [Treatment of plantal warts in children]. | 1976 | Vestn Dermatol Venerol | pmid:997868 |
El-DIN S and Aboul-Ela S | Fish meal supplementation of chick starting rations containing cottonseed cake. | 1976 | Beitr Trop Landwirtsch Veterinarmed | pmid:990100 |
Couch JR and Thomas MC | A comparison of chemical methods for the determination of available lysine in various proteins. | 1976 Sep-Oct | J. Agric. Food Chem. | pmid:989491 |
El-Nockrashy AS et al. | Biochemical changes in cottonseed during development and maturity. | 1976 | Nahrung | pmid:989153 |
El-Nockrashy AS et al. | Cottonseed colour fixed pigments. Part I. Selectivity of hexane isomers. | 1976 | Nahrung | pmid:989152 |
Hutchinson RW et al. | Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells. | 1998 | Cell Biol. Toxicol. | pmid:9879931 |
Velasquez-Pereira J et al. | Reproductive effects of feeding gossypol and vitamin E to bulls. | 1998 | J. Anim. Sci. | pmid:9856400 |
Velasquez-Pereira J et al. | Effects on performance, tissue integrity, and metabolism of vitamin E supplementation for beef heifers fed a diet that contains gossypol. | 1998 | J. Anim. Sci. | pmid:9856398 |
Blackwelder JT et al. | Milk production and plasma gossypol of cows fed cottonseed and oilseed meals with or without rumen-undegradable protein. | 1998 | J. Dairy Sci. | pmid:9839237 |
Zhang Y et al. | The (-)-enantiomer of gossypol inhibits proliferation of stromal cells derived from human breast adipose tissues by enhancing transforming growth factor beta1 production. | 1998 | Int. J. Oncol. | pmid:9824647 |
Prost J et al. | Digestion and absorption rates of [3H]-oleic acid and [14C]-triolein do not differ in rats fed heated (-) and (+) gossypol cottonseed and soybean flours. | 1998 | J. Nutr. | pmid:9808656 |
Michael AE | 11 beta HSD and the mechanism of gossypol-induced hypokalemia. | 1998 | Int. J. Androl. | pmid:9805249 |
Velasquez-Pereira J et al. | Long-term effects of gossypol and vitamin E in the diets of dairy bulls. | 1998 | J. Dairy Sci. | pmid:9785239 |
Hutchinson RW et al. | Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9707507 |
Guo J and Reidenberg MM | Inhibition of 11beta-hydroxysteroid dehydrogenase by bioflavonoids and their interaction with furosemide and gossypol. | 1998 | J. Lab. Clin. Med. | pmid:9665369 |
Frick J et al. | [A pill for the man? Current status of fertility control in the man]. | 1998 | Gynakol Geburtshilfliche Rundsch | pmid:9658718 |
Monsees TK et al. | Influence of gossypol on the secretory function of cultured rat sertoli cells. | 1998 | Toxicon | pmid:9655644 |
Teng CS | c-fos protein expression in apoptotic rat spermatocytes induced by gossypol. | 1998 | Contraception | pmid:9649921 |
Waites GM et al. | Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. | 1998 | Int. J. Androl. | pmid:9639146 |
Yu ZH and Chan HC | Gossypol as a male antifertility agent--why studies should have been continued. | 1998 | Int. J. Androl. | pmid:9639145 |
Chan WK et al. | Effects of alpha-tocopherol on metmyoglobin formation and reduction in beef from cattle fed soybean or cottonseed meal diets. | 1998 | J. Anim. Sci. | pmid:9621948 |
Teng CS and Vilagrasa X | Biphasic c-Myc protein expression during gossypol-induced apoptosis in rat spermatocytes. | 1998 | Contraception | pmid:9589839 |
Gomez MS et al. | Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum. | 1997 | Mol. Biochem. Parasitol. | pmid:9497046 |
Gupta GS and Kang BP | Quenching of intrinsic fluorescence of sperm specific LDH by optical isomers of gossypol. | 1997 | Gen. Physiol. Biophys. | pmid:9452944 |
Blackstaffe L et al. | Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. | 1997 | Melanoma Res. | pmid:9429219 |
Kumar M et al. | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. | 1997 | Contraception | pmid:9408707 |
Tran PT et al. | Effect of gossypol on Spisula sperm observed with real-time confocal microscopy, polarized light microscopy, and video microscopy. | 1997 | Biol. Bull. | pmid:9390392 |
Wu T et al. | [Effects of gossypol acetic acid on human ejaculated sperm Ca2+ influx and rat vas deferens contraction action]. | 1996 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:9388965 |
Yu BZ et al. | Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates. | 1997 | Biochemistry | pmid:9376343 |
Roberts R | Protein products and hulls for animal foods. | 1976 | J Am Oil Chem Soc | pmid:932385 |
Brocas C et al. | Deleterious actions of gossypol on bovine spermatozoa, oocytes, and embryos. | 1997 | Biol. Reprod. | pmid:9314596 |
Bernard JK and Calhoun MC | Response of lactating dairy cows to mechanically processed whole cottonseed. | 1997 | J. Dairy Sci. | pmid:9313148 |
Kalla NR et al. | alpha-Glucosidase activity in the rat epididymis under different physiological conditions. | 1997 | Int. J. Androl. | pmid:9292319 |
Zhang Y et al. | Estrogen and progestin cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy. | 1996 | Chin. Med. J. | pmid:9275362 |
Akingbemi BT et al. | Chronic ethanol intake may delay the onset of gossypol-induced infertility in the male rat. | 1997 Jul-Aug | Andrologia | pmid:9263570 |
Akingbemi BT et al. | The influence of protein malnutrition on the antifertility action of gossypol in the Trypanosoma brucei-infected rat: some ultrastructural observations from the testis. | 1997 Jul-Aug | Reprod. Toxicol. | pmid:9241673 |
Blauwiekel R et al. | Effect of whole cottonseed, gossypol, and ruminally protected lysine supplementation on milk yield and composition. | 1997 | J. Dairy Sci. | pmid:9241597 |
Deoras DP et al. | Effect of gossypol on hepatic and serum gamma-glutamyltransferase activity in rats. | 1997 | Vet. Res. Commun. | pmid:9232775 |
Ligueros M et al. | Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. | 1997 | Br. J. Cancer | pmid:9218727 |
Ye WS et al. | [The antifertility effect of gossypol plus testosterone and estrogen]. | 1996 | Yao Xue Xue Bao | pmid:9208651 |
Sessions RB et al. | A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia. | 1997 | Protein Eng. | pmid:9194154 |
Shidaifat F et al. | Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle. | 1997 Mar-Apr | Anticancer Res. | pmid:9137441 |
Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9115008 |
Chang WY et al. | Gossypol induces spermidine/spermine N1-acetyltransferase in canine prostate epithelial cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070284 |
Broderick GA | Effect of processing on protein utilization by ruminants. | 1977 | Adv. Exp. Med. Biol. | pmid:906927 |
Rekha GK and Sladek NE | Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol. | 1997 | Adv. Exp. Med. Biol. | pmid:9059615 |
Cruz-Vega DE et al. | Determination of the antiamebic effect of a metronidazole/gossypol blend. | 1997 | Arch. Med. Res. | pmid:9033109 |
González-Garza MT et al. | Gossypol anti-amebic effect in vivo. | 1997 | Arch. Med. Res. | pmid:9033108 |
Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9013060 |
Soubeyrand S et al. | Purification of a novel phospholipase A2 from bovine seminal plasma. | 1997 | J. Biol. Chem. | pmid:8995251 |