Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ghittino P et al. | Experimental dietary hepatoma in rainbow trout. The role of cottonseed meals and other diets. | 1967 | Cancro | pmid:4303305 |
Braham JE et al. | Effect of gossypol on the iron-binding capacity of serum in swine. | 1967 | J. Nutr. | pmid:6052995 |
Roehm JN et al. | Accumulation and elimination of dietary gossypol in the organs of rainbow trout. | 1967 | J. Nutr. | pmid:6054742 |
Sharma MP et al. | Effects of levels of protein and gossypol, and length of feeding period on the accumulation of gossypol in tissues of swine. | 1966 | J. Nutr. | pmid:5931188 |
Muzaffaruddin M and Saxena ER | Physicochemical studies on the composition and stability of metal-gossypol complexes. I. Fe+++ gossypol complex. | 1966 | J Am Oil Chem Soc | pmid:5939582 |
Clawson AJ and Smith FH | Effect of dietary iron on gossypol toxicity and on residues of gossypil in porcine liver. | 1966 | J. Nutr. | pmid:5950205 |
Myers BD and Throneberry GO | Effect of gossypol on some oxidative respiratory enzymes. | 1966 | Plant Physiol. | pmid:4287149 |
VERMEL EM and KRUGLYAK SA | ANTITUMOR ACTIVITY OF GOSSYPOL IN EXPERIMENTS ON TRANSPLANTABLE TUMORS. | 1965 Jan-Feb | Fed Proc Transl Suppl | pmid:14275562 |
Smith FH and Clawson AJ | Effect of diet on accumulation of gossypol in the organs of swine. | 1965 | J. Nutr. | pmid:5892976 |
Danke RJ and Tillman AD | Effect of free gossypol and supplemental dietary iron on blood constituents of rats. | 1965 | J. Nutr. | pmid:5897732 |