Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Balci A et al. | Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. | 1999 | Tohoku J. Exp. Med. | pmid:10622208 |
Alheid U et al. | Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. | 1987 | Thromb. Res. | pmid:3499684 |
Hassan ME et al. | Reversibility of the reproductive toxicity of gossypol in peripubertal bulls. | 2004 | Theriogenology | pmid:15037004 |
Chenoweth PJ et al. | Characterization of gossypol-induced sperm abnormalities in bulls. | 2000 | Theriogenology | pmid:10798496 |
Beaudoin AR | The embryotoxicity of gossypol. | 1985 | Teratology | pmid:4049283 |
Nayak BN and Buttar HS | Induction of sister chromatid exchanges and chromosome damage by gossypol in bone marrow cells of mice. | 1986 | Teratog., Carcinog. Mutagen. | pmid:2874644 |
Krylov VF | [Treatment of patients with influenza]. | 1975 | Ter. Arkh. | pmid:52894 |
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Ilkevych NS et al. | Vibrational spectra, structure and antioxidant activity of gossypol imine derivatives. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22078080 |
Shen YL et al. | Study on structure and characterization of inclusion complex of gossypol/beta cyclodextrin. | 2005 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:15741097 |
Shen YL et al. | Determinations of the inclusion complex between gossypol and beta-cyclodextrin. | 2006 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:16877036 |
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Wu YW et al. | [Electrophysiological and ultrastructural studies of the blood-epididymis barrier of the rat]. | 1986 | Shi Yan Sheng Wu Xue Bao | pmid:3577546 |
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Yuan JR | [Methods of extraction and purification of gossypol]. | 1984 | Shengzhi Yu Biyun | pmid:12339570 |
Wang R | [Sister chromatid exchanges in gossypol formic acid users after its discontinuation]. | 1986 | Shengzhi Yu Biyun | pmid:12341303 |
Wu GP | [Gossypol and its related compounds as contraceptive drugs and drugs for gynecological diseases]. | 1988 | Shengzhi Yu Biyun | pmid:12282152 |
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[The clinical study of gossypol in 8,806 men]. | 1985 | Shengzhi Yu Biyun | pmid:12267797 | |
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Anderson MA et al. | Targeting BCL2 for the treatment of lymphoid malignancies. | 2014 | Semin. Hematol. | pmid:25048785 |
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Gadelha IC et al. | Gossypol promotes degeneration of ovarian follicles in rats. | 2014 | ScientificWorldJournal | pmid:25540815 |
Gadelha IC et al. | Gossypol toxicity from cottonseed products. | 2014 | ScientificWorldJournal | pmid:24895646 |
Baugher WL and Campbell TC | Gossypol detoxication by fungi. | 1969 | Science | pmid:5786644 |
Maugh TH | Male "pill" blocks sperm enzyme. | 1981 | Science | pmid:7193910 |
Eagle E | Chronic Toxicity of Gossypol. | 1949 | Science | pmid:17742136 |
Montamat EE et al. | Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. | 1982 | Science | pmid:6750791 |
Fishbein L | Natural non-nutrient substances in the food chain. | 1972 | Sci. Total Environ. | pmid:4121147 |
Xue SP et al. | Subcellular site of antispermatogenic effect of gossypol and its possible molecular mechanism of action. | 1983 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:6623054 |
Wu YW et al. | Effect of gossypol on the potential difference of rat seminiferous tubules. | 1985 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:4012264 |
Shepu X et al. | Antispermatogenic effect of gossypol on the germinal epithelium of the rat testes. A cytological, autoradiographical and ultrastructural observation. | 1980 | Sci. Sin. | pmid:7403840 |
Bi XF et al. | The effect of gossypol on ATPase activity of the kidney. | 1981 | Sci. Sin. | pmid:6266011 |
Wu G et al. | Temporal allocation of metabolic tolerance in the body of beet armyworm in response to three gossypol-cotton cultivars. | 2009 | Sci. China, C, Life Sci. | pmid:20016971 |
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Demoulin A | [Male contraception]. | 1984 | Rev Med Liege | pmid:6729295 |
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Chang WY et al. | Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8827831 |
Mushtaq M et al. | Gossypol inhibits human chorionic gonadotropin-stimulated testosterone production by cultured canine testicular interstitial cells. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8829766 |
Moh PP et al. | Effect of gossypol on 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase activities in adult rat testes. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8272571 |
Chang CJ et al. | Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8480076 |