Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Moore GD et al. | Inhibition of sperm migration, fertilization and implantation in rats by precoital intrauterine administration of gossypol or nonoxynol-9. | 1988 | Contraception | pmid:2835205 |
Sakesena SK et al. | Gossypol: its toxicological and endocrinological effects in male rabbits. | 1981 | Contraception | pmid:7297071 |
Tso WW and Lee CS | Variations of gossypol sensitivity in boar spermatozoal electron transport chain segments. | 1981 | Contraception | pmid:7318437 |
Ojha P et al. | Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. | 2006 | Contraception | pmid:16371305 |
Frick J et al. | Clinical microdose study of gossypol: effect on sperm motility and renal function. | 1988 | Contraception | pmid:3370988 |
Drayer DE and Reidenberg MM | Gossypol and Na+, K+ ATPase from human erythrocytes. | 1988 | Contraception | pmid:2848657 |
Xue SP et al. | Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. | 1988 | Contraception | pmid:3370989 |
Beaudoin AR | A developmental toxicity evaluation of gossypol. | 1988 | Contraception | pmid:3370993 |
Yang ZJ et al. | Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men. | 2004 | Contraception | pmid:15325889 |
Kumar M et al. | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. | 1997 | Contraception | pmid:9408707 |
Wu DF and Reidenberg MM | Stereoselective interaction between gossypol and rat plasma. | 1990 | Contraception | pmid:2335102 |
Lin YC et al. | Effect of gossypol on thyroid hormones in young female rats. | 1990 | Contraception | pmid:2335106 |
Kim I et al. | Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. | 1987 | Contraception | pmid:3608484 |
Sinha Hikim AP and Hoffer AP | Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol. | 1987 | Contraception | pmid:3621939 |
Polsky B et al. | Inactivation of human immunodeficiency virus in vitro by gossypol. | 1989 | Contraception | pmid:2473865 |
Wang C and Yeung RT | Gossypol and hypokalaemia. | 1985 | Contraception | pmid:3910352 |
Han ML et al. | Gossypol in the treatment of endometriosis and uterine myoma. | 1987 | Contrib Gynecol Obstet | pmid:3121251 |
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Graier WF et al. | High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions. | 1996 | Diabetes | pmid:8826976 |
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Krasil'nikov OV et al. | [Dependence of the protonophore and channel-forming capacity of gossypol on the pH]. | 1985 | Dokl. Akad. Nauk SSSR | pmid:2408838 |
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Reynolds JM and Tone JN | Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats. | 1988 | Drug Chem Toxicol | pmid:3402348 |
Tone JN and Jensen DR | Radioiron utilization and gossypol acetic acid in male rats. | 1985 | Drug Chem Toxicol | pmid:4017900 |
Lagerlöf RK and Tone JN | The effect of gossypol acetic acid on female reproduction. | 1985 | Drug Chem Toxicol | pmid:4092619 |
Ren T et al. | Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer. | 2015 | Drug Des Devel Ther | pmid:26089640 |
Ren T et al. | Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. | 2014 | Drug Des Devel Ther | pmid:25548514 |
Qian C et al. | Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor. | 2014 | Drug Des Devel Ther | pmid:24872679 |
Matlin SA | Prospects for pharmacological male contraception. | 1994 | Drugs | pmid:7533693 |
Wu D | An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. | 1989 | Drugs | pmid:2680434 |
Gombe S | A review of the current status in male contraceptive studies. | 1983 | East Afr Med J | pmid:6354690 |
Suzuki H et al. | [Studies on naturally occurring toxic substances (III). Determination of gossypol in seed kernels of cotton plants by high performance liquid chromatography]. | 1986 | Eisei Shikenjo Hokoku | pmid:3567428 |
Sabirova FM et al. | [Immunomodulating effect of the novel water-soluble gossypol derivative Mebavin in adjuvant arthritis]. | 2004 Mar-Apr | Eksp Klin Farmakol | pmid:15188763 |
Sabirova FM and Madaminov AA | [Anti-inflammatory activity of the novel water soluble gossipol derivative mebavine]. | 2003 Nov-Dec | Eksp Klin Farmakol | pmid:14743712 |
Colman N et al. | Non-mutagenicity of gossypol in the Salmonella/mammalian-microsome plate assay. | 1979 | Environ Mutagen | pmid:399915 |
Gao F et al. | Interactive effects of elevated CO2 and cotton cultivar on tri-trophic interaction of Gossypium hirsutum, Aphis gossyppii, and Propylaea japonica. | 2008 | Environ. Entomol. | pmid:18348793 |
Stipanovic RD et al. | Effect of racemic, (+)- and (-)-gossypol on survival and development of Heliothis virescens larvae. | 2008 | Environ. Entomol. | pmid:19036185 |
Majumdar SK et al. | Genotoxic effects of gossypol acetic acid on cultured murine erythroleukemia cells. | 1991 | Environ. Mol. Mutagen. | pmid:1915316 |
Liang JC and Ye WS | Clastogenicity of a male contraceptive, gossypol, in mammalian cell cultures with and without the metabolic activation by S9 mix. | 1985 | Environ. Res. | pmid:3967635 |
Aneja R et al. | Modulatory influence of tin-protoporphyrin on gossypol-induced alterations of heme oxygenase activity in male Wistar rats. | 2003 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:14527098 |
Akinola OB et al. | Proteinaceous diet inhibits gossypol-induced spermatotoxicity. | 2006 Jul-Sep | Eur J Histochem | pmid:16920644 |
Dao VT et al. | Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone. | 2004 | Eur J Med Chem | pmid:15236842 |
Zhang L et al. | Chiral gossypol derivatives: evaluation of their anticancer activity and molecular modeling. | 2009 | Eur J Med Chem | pmid:19447525 |