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Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. |
2008 |
Mol. Cancer Ther. |
pmid:18645028
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Jia L et al. |
Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. |
2008 |
Cancer Chemother. Pharmacol. |
pmid:17356822
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Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. |
2008 |
Curr. Med. Chem. |
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EI MS and ESI MS studies of the bisesquiterpene from cotton seeds: Gossypol and its Aza-derivatives. |
2008 |
J Mass Spectrom |
pmid:18200654
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Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. |
2008 |
Cancer Biol. Ther. |
pmid:18376141
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Dowd MK and Pelitire SM |
HPLC preparation of the chiral forms of 6-methoxy-gossypol and 6,6'-dimethoxy-gossypol. |
2008 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:18407810
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Ojha P et al. |
Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. |
2008 |
Anim. Reprod. Sci. |
pmid:17207942
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Balakrishnan K et al. |
Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. |
2008 |
Blood |
pmid:18566329
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Wang X et al. |
Bioactivities of gossypol, 6-methoxygossypol, and 6,6'-dimethoxygossypol. |
2008 |
J. Agric. Food Chem. |
pmid:18517219
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Johnson PW |
New targets for lymphoma treatment. |
2008 |
Ann. Oncol. |
pmid:18519406
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Marzo I and Naval J |
Bcl-2 family members as molecular targets in cancer therapy. |
2008 |
Biochem. Pharmacol. |
pmid:18638457
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Trischitta F and Faggio C |
Gossypol affects ion transport in the isolated intestine of the seawater adapted eel, Anguilla anguilla. |
2008 |
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |
pmid:18606239
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[Progress in small-molecule inhibitors of Bcl-2 family proteins]. |
2008 |
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pmid:18819468
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Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. |
2008 |
Eur. J. Pharmacol. |
pmid:18930721
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Sun J et al. |
ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. |
2008 |
Anticancer Drugs |
pmid:18827561
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Janssen CO et al. |
Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. |
2008 |
Bioorg. Med. Chem. Lett. |
pmid:18845435
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Mi JX et al. |
Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. |
2008 |
Acta Pharmacol. Sin. |
pmid:19026166
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Stipanovic RD et al. |
Effect of racemic, (+)- and (-)-gossypol on survival and development of Heliothis virescens larvae. |
2008 |
Environ. Entomol. |
pmid:19036185
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Karaca B et al. |
Profiling of angiogenic cytokines produced by hormone- and drug-refractory prostate cancer cell lines, PC-3 and DU-145 before and after treatment with gossypol. |
2008 |
Eur. Cytokine Netw. |
pmid:19103523
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Cui G et al. |
Gossypol with methyltestosterone and ethinylestradiol male does not affect rat spermatogonial stem cell differentiation. |
2007 Mar-Apr |
Arch. Androl. |
pmid:17453689
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Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. |
2007 Jan-Feb |
Anticancer Res. |
pmid:17352222
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Meng Y et al. |
(-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. |
2007 |
Leuk. Lymphoma |
pmid:17926190
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Mao YB et al. |
Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. |
2007 |
Nat. Biotechnol. |
pmid:17982444
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Relative toxicity of gossypol enantiomers in laying and broiler breeder hens. |
2007 |
Poult. Sci. |
pmid:17297172
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Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. |
2007 |
Clin. Exp. Pharmacol. Physiol. |
pmid:17250644
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Leyman A et al. |
The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts. |
2007 |
Cell. Signal. |
pmid:17355905
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Costantino A et al. |
Current status and future perspectives in male contraception. |
2007 |
Minerva Ginecol |
pmid:17576406
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Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. |
2007 |
J. Med. Chem. |
pmid:17552510
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Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. |
2007 |
Int. J. Cancer |
pmid:17597109
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Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins. |
2007 |
Cell Death Differ. |
pmid:17541428
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Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. |
2007 |
Radiother Oncol |
pmid:17521756
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A high-throughput screen for aggregation-based inhibition in a large compound library. |
2007 |
J. Med. Chem. |
pmid:17447748
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Gossypol inhibits proliferation of endometrioma cells in culture. |
2007 |
Asian J. Androl. |
pmid:17486280
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Determining larval host plant use by a polyphagous lepidopteran through analysis of adult moths for plant secondary metabolites. |
2007 |
J. Chem. Ecol. |
pmid:17492366
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Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. |
2007 |
J. Med. Chem. |
pmid:17636950
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Loberg RD et al. |
In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. |
2007 |
Neoplasia |
pmid:18084610
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The in vitro effect of gossypol and its interaction with salts on conidial germination and viability of Fusarium oxysporum sp. vasinfectum isolates. |
2007 |
J. Appl. Microbiol. |
pmid:18045422
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Akinola OB et al. |
Spermatoprotective activity of the leaf extract of Psidium guajava Linn. |
2007 |
Niger Postgrad Med J |
pmid:18163132
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Gerasimidis K et al. |
Preparation of an edible cottonseed protein concentrate and evaluation of its functional properties. |
2007 |
Int J Food Sci Nutr |
pmid:17710592
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Carruthers NJ et al. |
Gossypol inhibits calcineurin phosphatase activity at multiple sites. |
2007 |
Eur. J. Pharmacol. |
pmid:17141216
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Liu F et al. |
Pharmacophore identification of KSP inhibitors. |
2007 |
Bioorg. Med. Chem. Lett. |
pmid:17095225
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Zhang M et al. |
Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways. |
2007 |
Life Sci. |
pmid:17156797
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Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. |
2007 |
J. Biol. Chem. |
pmid:17110373
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Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. |
2007 |
Bioorg. Med. Chem. |
pmid:17227711
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[The effect of gossypol, praziquantel and artemether on recombinant lactate dehydrogenase from Schistosoma japonicum]. |
2007 |
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi |
pmid:18441994
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Denisov AY et al. |
Heat-induced dimerization of BCL-xL through alpha-helix swapping. |
2007 |
Biochemistry |
pmid:17223694
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Makkar HP et al. |
Plant secondary metabolites. |
2007 |
Methods Mol. Biol. |
pmid:19238775
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Huang YW et al. |
Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. |
2006 Sep-Oct |
Anticancer Res. |
pmid:17094491
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Huang YW et al. |
Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. |
2006 May-Jun |
Anticancer Res. |
pmid:16827126
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Akinola OB et al. |
Proteinaceous diet inhibits gossypol-induced spermatotoxicity. |
2006 Jul-Sep |
Eur J Histochem |
pmid:16920644
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