| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Myxosarcoma | D009236 | 1 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Medeiros YS et al. | Gossypol affects the responsiveness of isolated rat myometrium and vas deferens. | 1989 | Braz. J. Med. Biol. Res. | pmid:2638200 |
| Sipkema P et al. | Does the endothelium play a role in flow-dependent constriction? A study in the isolated rabbit femoral artery. | 1989 | Blood Vessels | pmid:2641926 |
| Adlakha RC et al. | Modulation of 4'-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol. | 1989 | Cancer Res. | pmid:2539251 |
| Kanwar U et al. | Gossypol inhibition of Ca++ uptake and Ca++-ATPase in human ejaculated spermatozoal plasma membrane vesicles. | 1989 | Contraception | pmid:2541968 |
| Morgan SE | Gossypol as a toxicant in livestock. | 1989 | Vet. Clin. North Am. Food Anim. Pract. | pmid:2667706 |
| Wu D | An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. | 1989 | Drugs | pmid:2680434 |
| Allamiiarova SA and Urazmetov KG | [The effect of batriden and dexasone on immune status indices in animals with experimental allergic contact dermatitis]. | 1989 | Vestn Dermatol Venerol | pmid:2609756 |
| Han SD et al. | [Study on quality of gossypol recrystalized from chloroform]. | 1989 | Yao Xue Xue Bao | pmid:2609986 |
| Obeidy A et al. | The effect of gossypol on serum lipoproteins of adult rats. | 1989 | Horm. Metab. Res. | pmid:2613178 |
| Deng HL et al. | [The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats]. | 1989 | Yao Xue Xue Bao | pmid:2618689 |
| Tareeva IE et al. | [Treatment of chronic glomerulonephritis with cytostatics]. | 1989 | Ter. Arkh. | pmid:2799726 |
| Haschek WM et al. | Cottonseed meal (gossypol) toxicosis in a swine herd. | 1989 | J. Am. Vet. Med. Assoc. | pmid:2777708 |
| Uchijima Y et al. | [Effects of gossypol on human specific lactate dehydrogenase-C4 (LDH-C4)]. | 1989 | Nihon Funin Gakkai Zasshi | pmid:12158558 |
| Katoh N and Kimura K | Inhibition by gossypol of cyclic nucleotide-independent phosvitin kinase from pig testis. | 1989 | Nippon Juigaku Zasshi | pmid:2927017 |
| Nakamura M et al. | Metabolism of round spermatids in the rat: effect of gossypol on the glucose transport. | 1988 Sep-Oct | Andrologia | pmid:3207199 |
| Ershov FI et al. | [Interferonogenic activity of low-molecular compounds of plant origin]. | 1988 Nov-Dec | Vopr. Virusol. | pmid:2470203 |
| Wang JM et al. | The correlation between the gossypol contents in blood plasma, rete testis fluid, and cauda epididymal fluid following chronic treatment with gossypol in rats. | 1988 Nov-Dec | J. Androl. | pmid:3215825 |
| Zakhidov ST et al. | [Clastogenic action of gossypol on spermatogenic cells in rats studied by counting micronuclei]. | 1988 May-Jun | Izv Akad Nauk SSSR Biol | pmid:3411013 |
| Tazulakhova EB et al. | [Effect of low-molecular interferon inducers in experimental hepatitis in mice]. | 1988 Mar-Apr | Vopr. Virusol. | pmid:2457987 |
| Tanphaichitr N et al. | Differential effects of (+) and (-) gossypol enantiomers on mitochondrial function and proliferation of cultured TM4 cells. | 1988 Jul-Aug | J. Androl. | pmid:3182397 |
| Chen QQ | [Relationship between gossypol concentration and testicular damage]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2968182 |
| Cheng JX | [Effect of gossypol (+/-, +, -) on Leydig cells of the rat in vitro]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970318 |
| Tang MY | [Electron microscopic observation of the effect of gossypol on atypical hyperplasia of the endometrium]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970320 |
| Ye WS | [Clastogenicity of gossypol as a male contraceptive in sperm head anomalies in mice]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970321 |
| Wang YF | [Observation on blood biochemical indices after gossypol treatment in gynecological cases]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2972411 |
| Fu YF et al. | Effects of gossypol on the activity of rabbit kidney Na,K-ATPase and the functions of human erythrocyte membrane. | 1988 | Prog. Clin. Biol. Res. | pmid:2975784 |
| Zhou LF | [Effect of racemic, (+),(-) gossypol on rat testis, epididymis, liver and kidney]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2978403 |
| Moore GD et al. | Inhibition of sperm migration, fertilization and implantation in rats by precoital intrauterine administration of gossypol or nonoxynol-9. | 1988 | Contraception | pmid:2835205 |
| Duo X et al. | Clinical safety of long-term administration of gossypol in 32 cases. | 1988 | Contraception | pmid:3370987 |
| van Ypersele de Strihou C et al. | Effects of gossypol on the kidney with special emphasis on potassium (K) excretion. | 1988 | Contraception | pmid:3370990 |
| Heywood R | The toxicology of gossypol acetic acid and (-)-gossypol. | 1988 | Contraception | pmid:3370991 |
| Wu GP | [Gossypol and its related compounds as contraceptive drugs and drugs for gynecological diseases]. | 1988 | Shengzhi Yu Biyun | pmid:12282152 |
| Meng GD et al. | Follow-up of men in the recovery period immediately after the cessation of gossypol treatment. | 1988 | Contraception | pmid:3131064 |
| Ruppel A and Shi YE | Schistosoma mansoni: effect of gossypol on infections in mice. | 1988 | Trop. Med. Parasitol. | pmid:3140355 |
| Zhong CQ | [Studies on sperm function in man long after cessation of gossypol administration]. | 1988 | Shengzhi Yu Biyun | pmid:12315492 |
| Teng CS and Fei RR | The effects of gossypol on nuclear protein in rat testes. II. The synthesis of histones and testis-specific proteins after gossypol treatment. | 1988 | Contraception | pmid:3371000 |
| Hoffer AP et al. | Antifertility, spermicidal and ultrastructural effects of gossypol and derivatives administered orally and by intratesticular injections. | 1988 | Contraception | pmid:3371001 |
| Morgan S et al. | Clinical, clinicopathologic, pathologic, and toxicologic alterations associated with gossypol toxicosis in feeder lambs. | 1988 | Am. J. Vet. Res. | pmid:3377308 |
| Hudson LM et al. | Gossypol toxicosis in a herd of beef calves. | 1988 | J. Am. Vet. Med. Assoc. | pmid:3391858 |
| Reyes J et al. | A bioenergetic model of gossypol action: effects of gossypol on adult rat spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354654 |
| Meng GD et al. | Recovery of sperm production following the cessation of gossypol treatment: a two-centre study in China. | 1988 | Int. J. Androl. | pmid:3356480 |
| Rikihisa Y and Lin YC | Ultrastructure of the testis and epididymis of Japanese quail (Coturnix coturnix japonica) administered gossypol. | 1988 | Poult. Sci. | pmid:3413024 |
| Ye XQ | [Clinical and experimental study of gossypol in the treatment of dysfunctional menorrhagia, endometriosis and fibromyoma of the uterus]. | 1988 | Zhong Xi Yi Jie He Za Zhi | pmid:3191544 |
| Rajpurohit R and Giridharan N | Failure of oral gossypol to inhibit hepatic microsomal and cytosolic drug-metabolising enzymes. | 1988 | Biochem. Pharmacol. | pmid:3202895 |
| Dudel C and Förstermann U | Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo. | 1988 | Eur. J. Pharmacol. | pmid:2450761 |
| Radigue C et al. | Early effects of gossypol on the testis and epididymis in the rat. | 1988 | Reprod Nutr Dev | pmid:3253903 |
| Wu DF et al. | [Determination of (+)- and (-)-gossypol in human plasma using high performance liquid chromatography with pre-column chemical derivatization]. | 1988 | Yao Xue Xue Bao | pmid:3256191 |
| Jennings MB and Reidenberg MM | Adaptation to nephrotoxic chemicals. | 1988 | Proc. Soc. Exp. Biol. Med. | pmid:3205883 |
| Glander HJ | [Gossypol and other nonhormonal substances for the inhibition of male fertility]. | 1988 | Zentralbl Gynakol | pmid:3213305 |
| Coutinho EM and Melo JF | Clinical experience with gossypol in non-Chinese men: a follow-up. | 1988 | Contraception | pmid:3286112 |