MeSH term | MeSH ID | Detail |
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Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
Myxosarcoma | D009236 | 1 associated lipids |
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Krassnigg F et al. | Investigations on the functional role of angiotensin converting enzyme (ACE) in human seminal plasma. | 1986 | Adv. Exp. Med. Biol. | pmid:3028067 |
Cherry JP et al. | Potential for improving cottonseed quality by genetic and agronomic practices. | 1978 | Adv. Exp. Med. Biol. | pmid:581532 |
Broderick GA | Effect of processing on protein utilization by ruminants. | 1977 | Adv. Exp. Med. Biol. | pmid:906927 |
Rekha GK and Sladek NE | Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol. | 1997 | Adv. Exp. Med. Biol. | pmid:9059615 |
Deck LM et al. | Inhibition of aldose reductase by gossypol and gossypol-related compounds. | 1999 | Adv. Exp. Med. Biol. | pmid:10352723 |
Yu ZH and Chan HC | Gossypol and hypokalemia: a critical review. | 1994 | Adv Contracept Deliv Syst | pmid:12289957 |
Tung DS et al. | Effect of long term gossypol treatment on human testicular structure. | 1987 | Adv Contracept Deliv Syst | pmid:12314752 |
Xian SC et al. | Antifertility treating with long term gossypol. | 1987 | Adv Contracept Deliv Syst | pmid:12268655 |
Sharma S et al. | Reversible antispermatogenic effect of gossypol in langur monkeys (Presbytis entellus entellus). | 1999 | Adv Contracept | pmid:10794043 |
Thomas KD et al. | Effects of an aqueous extract of cotton seed (Gossypium barbadense Linn.) on adult male rats. | 1991 | Adv Contracept | pmid:1776560 |
Achudume AC and Eno TL | Characterization of ion interference in gossypol consumption. | 1996 | Adv Contracept | pmid:8910664 |
VERMEL EM | THE SEARCH FOR ANTITUMOUR SUBSTANCES OF PLANT ORIGIN. | 1964 | Acta Unio Int Contra Cancrum | pmid:14151888 |
Dézsi L et al. | Regulation of femoral vascular resistance by adenine nucleotides via endothelial and smooth muscle receptors. | 1990 | Acta Physiol Hung | pmid:2339604 |
Shi YL et al. | Ion-channels in human sperm membrane and contraceptive mechanisms of male antifertility compounds derived from Chinese traditional medicine. | 2003 | Acta Pharmacol. Sin. | pmid:12511225 |
ZHU Y et al. | Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. | 2010 | Acta Pharmacol. Sin. | pmid:21102482 |
Wang MS et al. | Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol. | 2002 | Acta Pharmacol. Sin. | pmid:11860745 |
Xu WB et al. | The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis. | 2009 | Acta Pharmacol. Sin. | pmid:19363517 |
Mi JX et al. | Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. | 2008 | Acta Pharmacol. Sin. | pmid:19026166 |
Haider SG et al. | Reversible changes in rat spermatogenesis induced by an antifertility substance (Gossypol). A histochemical report. | 1985 | Acta Histochem. | pmid:2420139 |
Kalla NR and Sud S | Distribution of gossypol. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087941 |