| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Myxosarcoma | D009236 | 1 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Nutrition Disorders | D009748 | 6 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Pemphigoid, Bullous | D010391 | 8 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tuhácková Z | Staurosporine and gossypol are inhibitors of the function of peptide elongation factor 1 alpha from rabbit reticulocytes. | 1994 | Biochem. Mol. Biol. Int. | pmid:8032322 |
| Zhang YW et al. | [Estrogen and progesterone cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy]. | 1994 | Zhonghua Fu Chan Ke Za Zhi | pmid:8082445 |
| Benhaim P et al. | Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol. | 1994 | Inflammation | pmid:7843790 |
| Srivastava S et al. | Maturation, capacitation, and metabolism of goat spermatozoa using magnetic resonance methods. | 1993 Jul-Aug | Andrologia | pmid:8394662 |
| Andrade AT | [Information on advances in sciences and technology. Advances in contraceptive technology]. | 1993 | Bol Cent Biol Reprod | pmid:12345521 |
| Inoue H et al. | Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema. | 1993 | Br. J. Pharmacol. | pmid:7508328 |
| Sullivan JL et al. | Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. | 1993 | J. Dairy Sci. | pmid:8270698 |
| González-Garza MT et al. | Differential effects of the (+)- and (-)-gossypol enantiomers upon Entamoeba histolytica axenic cultures. | 1993 | J. Pharm. Pharmacol. | pmid:8095532 |
| MartÃnez F et al. | The antifertility agent, gossypol, releases calcium from rat liver mitochondria. | 1993 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:8097449 |
| Prusoff W et al. | Empirical and rational approaches for development of inhibitors of the human immunodeficiency virus--HIV-1. | 1993 | Pharmacol. Ther. | pmid:8022862 |
| Li H and He X | [The effects of optical isomers of gossypol on Sertoli cells in vitro]. | 1993 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:8242829 |
| Fornés MW et al. | Sperm motility loss induced by gossypol: relation with OH. scavengers, motile stimulators and malondialdehyde production. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8216260 |
| Moh PP et al. | Effect of gossypol on 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase activities in adult rat testes. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8272571 |
| Ye W et al. | Effect of intra-vas deferens injection of gossypol-polylactic acid on fertility and spermatogenesis in rats. | 1993 | Chin. Med. Sci. J. | pmid:8274715 |
| González-Garza MT et al. | Entamoeba histolytica: inhibition of malic enzyme and alcohol dehydrogenase by (+/- )-, (+)-, and (-)- gossypol. | 1993 | Arch. Med. Res. | pmid:8274846 |
| Wu D and Reidenberg MM | Effect of potassium deficiency and gossypol on urinary N-acetyl-beta-glucosaminidase excretion in the rat. | 1993 | Contraception | pmid:8275698 |
| Hu YF et al. | Gossypol inhibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells. | 1993 | Life Sci. | pmid:8255144 |
| Xiao DM et al. | [Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A]. | 1993 | Yao Xue Xue Bao | pmid:8285048 |
| Zhang SC et al. | [The adverse effects of the preparations of the active principles of Chinese herbal drugs]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8267848 |
| Aletor VA | Allelochemicals in plant foods and feedingstuffs: 1. Nutritional, biochemical and physiopathological aspects in animal production. | 1993 | Vet Hum Toxicol | pmid:8434459 |
| Gray ML et al. | Effects of dietary gossypol consumption on metabolic homeostasis and reproductive endocrine function in beef heifers and cows. | 1993 | J. Anim. Sci. | pmid:8270527 |
| Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. IV. The activity for the modification of core histones. | 1993 | Contraception | pmid:8403913 |
| Kulp SK et al. | In vitro uptake and autoradiographic localization of tritiated gossypol in Taenia taeniaeformis metacestodes. | 1993 | Parasitol. Res. | pmid:8327450 |
| Cuéllar A and RamÃrez J | Further studies on the mechanism of action of gossypol on mitochondrial membrane. | 1993 | Int. J. Biochem. | pmid:8405656 |
| Lei HQ and Xu YX | [Effects of gossypol acetic acid on the motility of rat oviduct smooth muscle]. | 1993 | Yao Xue Xue Bao | pmid:8328273 |
| Lin TS et al. | Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol. | 1993 | Biochem. Pharmacol. | pmid:8347147 |
| de Peyster A and Wang YY | Genetic toxicity studies of gossypol. | 1993 | Mutat. Res. | pmid:7692275 |
| Miranda FJ et al. | Endothelial modulation of 5-hydroxytryptamine-induced contraction in goat cerebral arteries. | 1993 | Gen. Pharmacol. | pmid:8365646 |
| Orhan G et al. | The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index. | 1993 | Contraception | pmid:8508667 |
| Hasegawa K et al. | Angiotensin II-induced endothelium-dependent relaxation of fowl aorta. | 1993 | Am. J. Physiol. | pmid:8498599 |
| Flack MR et al. | Oral gossypol in the treatment of metastatic adrenal cancer. | 1993 | J. Clin. Endocrinol. Metab. | pmid:8473376 |
| Chang CJ et al. | Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8480076 |
| Xu Y et al. | [Intratesticular subcapsular assay, a simple method for the preliminary screening of male contraceptives]. | 1993 | Yao Xue Xue Bao | pmid:8010008 |
| Price WD et al. | Naturally occurring toxins in feedstuffs: Center for Veterinary Medicine Perspective. | 1993 | J. Anim. Sci. | pmid:8407668 |
| Tres LL et al. | Permeable collagen-glycosaminoglycan cross-linked copolymers for the study of biological responses of cocultured Sertoli and spermatogenic cells. | 1992 Jul-Sep | Cell Biol. Toxicol. | pmid:1446259 |
| Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: III. The activity for the transcription of messenger RNA. | 1992 | Contraception | pmid:1559338 |
| Smith C et al. | Protection by albumin against the pro-oxidant actions of phenolic dietary components. | 1992 | Food Chem. Toxicol. | pmid:1379971 |
| Aregheore EM | A review of toxicity factors in some food and feedingstuffs in the nutrition of man and livestock in Nigeria. | 1992 | Vet Hum Toxicol | pmid:1621369 |
| Udoh P et al. | Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats. | 1992 | Contraception | pmid:1623720 |
| Udoh P and Patil DR | Effects of gossypol acetate on pituitary-adrenal axis in male albino rats. | 1992 | Contraception | pmid:1324828 |
| Sagach VF et al. | Functional hyperemia of skeletal muscle: role of endothelium. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282960 |
| Tkachenko MN et al. | Involvement of endothelium in vasodilating effects of vintoperol. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282997 |
| Zaidi R and Hadi SM | Complexes involving gossypol, DNA and Cu(II). | 1992 | Biochem. Int. | pmid:1290468 |
| Zaidi R and Hadi SM | Strand scission in DNA by gossypol and Cu(II): role of Cu(I) and oxygen-free radicals. | 1992 | J. Biochem. Toxicol. | pmid:1293310 |
| González-Garza MT et al. | Further studies on the in vitro activity of gossypol as antiamebic agent. | 1992 | Arch. Med. Res. | pmid:1340324 |
| Lan ZJ et al. | Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells. | 1992 | Contraception | pmid:1511610 |
| Jensen EC et al. | Lipoxygenase inhibitors shift the yeast/mycelium dimorphism in Ceratocystis ulmi. | 1992 | Appl. Environ. Microbiol. | pmid:1514797 |
| Stein RC et al. | A preliminary clinical study of gossypol in advanced human cancer. | 1992 | Cancer Chemother. Pharmacol. | pmid:1394805 |
| Bialy G and Alexander NJ | Developments in male contraception. | 1992 | Health Sex | pmid:12286189 |
| Lin YC et al. | Binding of 3H-gossypol in organelles of cultured bovine luteal cells. | 1992 | Life Sci. | pmid:1734162 |