| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Myxosarcoma | D009236 | 1 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Nutrition Disorders | D009748 | 6 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Pemphigoid, Bullous | D010391 | 8 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Reddy RM et al. | Pattern of ovarian and uterine carbohydrate metabolism during induced antiimplantation by (+)gossypol. | 1984 | Indian J. Exp. Biol. | pmid:6510968 |
| Nair IN and Bhiwgade DA | Effect of gossypol on pituitary reproductive axis: ultrastructural and biochemical studies. | 1990 | Indian J. Exp. Biol. | pmid:2253964 |
| Kaur P et al. | Effect of gossypol on testes & epididymis of albino rats. | 1988 | Indian J. Med. Res. | pmid:3169891 |
| Walia V et al. | Effect of gossypol on peripheral blood cells. | 1986 | Indian J. Med. Res. | pmid:3733198 |
| Liu Z et al. | Protective effect of gossypol on lipopolysaccharide-induced acute lung injury in mice. | 2013 | Inflamm. Res. | pmid:23435932 |
| Benhaim P et al. | Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol. | 1994 | Inflammation | pmid:7843790 |
| Grando SA et al. | Clinical and laboratory evaluation of hemocarboadsorption in autoimmune bullous dermatoses. | 1990 | Int J Artif Organs | pmid:2189836 |
| Gerasimidis K et al. | Preparation of an edible cottonseed protein concentrate and evaluation of its functional properties. | 2007 | Int J Food Sci Nutr | pmid:17710592 |
| Zubair H et al. | Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism. | 2016 | Int J Mol Sci | pmid:27331811 |
| Ignatova M et al. | Quaternized chitosan-coated nanofibrous materials containing gossypol: preparation by electrospinning, characterization and antiproliferative activity towards HeLa cells. | 2012 | Int J Pharm | pmid:22728261 |
| Mauron J | [Chemical behavior of proteins at the time of preparation of nutrients and their biological effects]. | 1970 | Int Z Vitaminforsch | pmid:5451301 |
| Huo M et al. | Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models. | 2013 | Int. Immunopharmacol. | pmid:23352443 |
| Prasad MR and Diczfalusy E | New contraceptives for men. What are the prospects? | 1983 | Int. J. Androl. | pmid:6413430 |
| Tso WW and Lee CS | Lactate dehydrogenase-X: an isozyme particularly sensitive to gossypol inhibition. | 1982 | Int. J. Androl. | pmid:7107034 |
| Tso WW and Lee CS | Potassium leakage: not the cause of gossypol induced anti-motility in spermatozoa. | 1982 | Int. J. Androl. | pmid:7118270 |
| Kaur S | Effect of gossypol on the concentration of sodium and potassium in the rat epididymis. | 1989 | Int. J. Androl. | pmid:2807585 |
| Coulson PB et al. | Short term metabolic effects of the anti-fertility agent, gossypol, on various reproductive organs of male mice. | 1980 | Int. J. Androl. | pmid:7440012 |
| Michael AE | 11 beta HSD and the mechanism of gossypol-induced hypokalemia. | 1998 | Int. J. Androl. | pmid:9805249 |
| Vongsorasak L and Svasti J | Inhibition of liquefaction and protein degradation in human semen by gossypol. | 1985 | Int. J. Androl. | pmid:3835162 |
| Meng GD et al. | Recovery of sperm production following the cessation of gossypol treatment: a two-centre study in China. | 1988 | Int. J. Androl. | pmid:3356480 |
| Akingbemi BT et al. | Infection with Trypanosoma brucei potentiates the antifertility effect of gossypol, especially in the protein-malnourished male rat. | 1996 | Int. J. Androl. | pmid:8876268 |
| Kalla NR et al. | alpha-Glucosidase activity in the rat epididymis under different physiological conditions. | 1997 | Int. J. Androl. | pmid:9292319 |
| Lindberg MC et al. | Comparative anti-fertility effects of gossypol enantiomers in male hamsters. | 1987 | Int. J. Androl. | pmid:3654015 |
| Steiner M et al. | In vivo study of LDH isoenzyme activities in heart, liver and testis cytosols of gossypol-treated rats. | 1984 | Int. J. Androl. | pmid:6526516 |
| Kainz V et al. | The effect of gossypol acetic acid on the different stages of the spermatogenic cycle in the rat. | 1988 | Int. J. Androl. | pmid:3215704 |
| Yu ZH and Chan HC | Gossypol as a male antifertility agent--why studies should have been continued. | 1998 | Int. J. Androl. | pmid:9639145 |
| Waites GM et al. | Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. | 1998 | Int. J. Androl. | pmid:9639146 |
| Breitbart H et al. | Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. | 1984 | Int. J. Androl. | pmid:6151940 |
| Qian SZ | Gossypol-hypokalaemia interrelationships. | 1985 | Int. J. Androl. | pmid:3908325 |
| Zhang GY et al. | Dynamic study of serum gonadotrophin and testosterone levels in gossypol-treated men. Long term follow-up study of 60 cases. | 1985 | Int. J. Androl. | pmid:3932223 |
| Gu ZP et al. | Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol. | 1990 | Int. J. Androl. | pmid:2117586 |
| Tang F and Wong PY | Serum potassium and aldosterone levels in gossypol-treated rats. | 1984 | Int. J. Androl. | pmid:6724725 |
| Eliasson R and Virji N | Effects of gossypol acetic acid on the activity of LDH-C4 from human and rabbit spermatozoa. | 1983 | Int. J. Androl. | pmid:6840877 |
| Aitken RJ et al. | An analysis of the direct effects of gossypol on human spermatozoa. | 1983 | Int. J. Androl. | pmid:6862672 |
| Johnsen O et al. | Gossypol; a potent inhibitor of human sperm acrosomal proteinase. | 1982 | Int. J. Androl. | pmid:6761275 |
| Cuéllar A and RamÃrez J | Further studies on the mechanism of action of gossypol on mitochondrial membrane. | 1993 | Int. J. Biochem. | pmid:8405656 |
| Grankvist K | Gossypol-induced free radical toxicity to isolated islet cells. | 1989 | Int. J. Biochem. | pmid:2684701 |
| Ionov M et al. | Stability and antioxidant activity of gossypol derivative immobilized on N-polyvinylpyrrolidone. | 2012 | Int. J. Biol. Macromol. | pmid:22910577 |
| Ko CH et al. | Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. | 2007 | Int. J. Cancer | pmid:17597109 |
| Chang CC et al. | Studies on gossypol. I. Toxicity, antifertility, and endocrine analyses in male rats. | 1982 | Int. J. Fertil. | pmid:6131039 |
| Ke YB and Tso WW | Variations of gossypol susceptibility in rat spermatozoa during spermatogenesis. | 1982 | Int. J. Fertil. | pmid:6122656 |
| Jiang J et al. | Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFbeta/Akt signaling. | 2009 | Int. J. Mol. Med. | pmid:19513537 |
| Ye W et al. | Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells. | 2010 | Int. J. Mol. Med. | pmid:20514430 |
| Zhang Y et al. | The (-)-enantiomer of gossypol inhibits proliferation of stromal cells derived from human breast adipose tissues by enhancing transforming growth factor beta1 production. | 1998 | Int. J. Oncol. | pmid:9824647 |
| Sadahira K et al. | Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. | 2014 | Int. J. Oncol. | pmid:25231749 |
| Strøm-Hansen T et al. | Interaction of gossypol with amino acids and peptides as a model of enzyme inhibition. | 1989 | Int. J. Pept. Protein Res. | pmid:2599770 |
| Maliwal BP et al. | Spectroscopic study of the interaction of gossypol with bovine serum albumin. | 1985 | Int. J. Pept. Protein Res. | pmid:4019021 |
| Final report on the safety assessment of Hydrogenated Cottonseed Oil, Cottonseed (Gossypium) Oil, Cottonseed Acid, Cottonseed Glyceride, and Hydrogenated Cottonseed Glyceride. | 2001 | Int. J. Toxicol. | pmid:11558638 | |
| Liang XS et al. | Developing gossypol derivatives with enhanced antitumor activity. | 1995 | Invest New Drugs | pmid:8729944 |
| Schelman WR et al. | A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer. | 2014 | Invest New Drugs | pmid:23860642 |