Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

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Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Lung Neoplasms D008175 171 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Myxosarcoma D009236 1 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Neuroblastoma D009447 66 associated lipids
Nutrition Disorders D009748 6 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pemphigoid, Bullous D010391 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Han SD et al. [Study on quality of gossypol recrystalized from chloroform]. 1989 Yao Xue Xue Bao pmid:2609986
Deng HL et al. [The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats]. 1989 Yao Xue Xue Bao pmid:2618689
Guo ZM et al. [Synthesis of mono-aldehyde gossypol and its analogues]. 1987 Yao Xue Xue Bao pmid:3450164
Zhou RH and Lin XD [Isolation of (-)-gossypol from natural plant]. 1987 Yao Xue Xue Bao pmid:3450165
Tang XC et al. [Comparative studies on the absorption, distribution and excretion of 14C-gossypol in four species of animals (author's transl)]. 1980 Yao Xue Xue Bao pmid:6779501
Jiang DH and Xue H [Monoanilinogossypol--the impurity possibly present in gossypol (author's transl)]. 1982 Yao Xue Xue Bao pmid:7102321
Wong SM et al. 14C-gossypol: optimum conditions for synthesis by cotton seedlings. 1983 Yao Xue Xue Bao pmid:6687973
Xiao DM et al. [Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A]. 1993 Yao Xue Xue Bao pmid:8285048
Chen Y et al. [Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice]. 1997 Yao Xue Xue Bao pmid:11596197
Yang B et al. [The effects of gossypol on rat luteal cells, human decidual cells and cytotrophoblasts]. 1997 Yao Xue Xue Bao pmid:11596304
Swan MA et al. Electron microscopic observations on the effect of gossypol on rat cauda epididymis. 1990 Z Mikrosk Anat Forsch pmid:2220026
Glander HJ [Gossypol and other nonhormonal substances for the inhibition of male fertility]. 1988 Zentralbl Gynakol pmid:3213305
Madzhidov UV [T-suppressors in experimental adjuvant arthritis and immunosuppression]. 1984 Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:6230839
Sorokina EV et al. [Influence of immunovac-VP-4 therapy on innate immunity effectors in patients with darier erythema annulare centrifugum]. 2013 Nov-Dec Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:24605681
Sorokina EV et al. [Features of dynamics of sera cytokines in patients with erythema multiforme during immunotherapy]. 2014 Jan-Feb Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:24738292
Huang HF and Wang M [Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro]. 1990 Zhong Xi Yi Jie He Za Zhi pmid:2208435
Wang YF [Late effect of gossypol treatment in gynecological diseases--a clinical study of 72 cases]. 1985 Zhong Xi Yi Jie He Za Zhi pmid:3158438
Ye XQ [Clinical and experimental study of gossypol in the treatment of dysfunctional menorrhagia, endometriosis and fibromyoma of the uterus]. 1988 Zhong Xi Yi Jie He Za Zhi pmid:3191544
Han ML [Clinical observation of the gossypol treatment of endometriosis and uterine myoma and the location of the pharmacological action]. 1982 Zhong Xi Yi Jie He Za Zhi pmid:6219819
Wang WH [Antagonistic effect of Smilax sp. on gossypol toxicity (author's transl)]. 1982 Zhong Yao Tong Bao pmid:6212150