Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hematologic Neoplasms D019337 4 associated lipids
Darier Disease D007644 2 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Retinoblastoma D012175 12 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Carcinoma, Mucoepidermoid D018277 3 associated lipids
Lung Injury D055370 14 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
Leukemia, Biphenotypic, Acute D015456 2 associated lipids
Myxosarcoma D009236 1 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Srivastava A et al. Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. 1989 Contraception pmid:2469550
Moore GD et al. Inhibition of sperm migration, fertilization and implantation in rats by precoital intrauterine administration of gossypol or nonoxynol-9. 1988 Contraception pmid:2835205
Fu YF et al. Effects of gossypol on the activity of kidney (Na+ + K+)-ATPase and the functions of erythrocyte membrane. 1988 Contraception pmid:2836126
White IG et al. Studies of the mechanism of action of gossypol as a male antifertility agent. 1988 Contraception pmid:2836127
Hahn DW et al. Antifertility and endocrine activities of gossypol in rodents. 1981 Contraception pmid:7273769
Waller DP et al. Antifertility effects of gossypol and its impurities on male hamsters. 1981 Contraception pmid:7285581
Chang MC et al. Effects of Gossypol on the fertility of male rats, hamsters and rabbits. 1980 Contraception pmid:7428357
Sakesena SK et al. Gossypol: its toxicological and endocrinological effects in male rabbits. 1981 Contraception pmid:7297071
Tso WW and Lee CS Variations of gossypol sensitivity in boar spermatozoal electron transport chain segments. 1981 Contraception pmid:7318437
Whaley KJ et al. Monkey lactate dehydrogenase-C4 as a model for the interaction of enzymes with gossypol. 1986 Contraception pmid:3769483
Ojha P et al. Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. 2006 Contraception pmid:16371305
Ma XN and Back DJ Inhibition of hepatic microsomal enzymes by gossypol in the rat. 1984 Contraception pmid:6478834
International Symposium on Gossypol Research for Fertility Regulation. Wuhan, China, 15-17 October 1986. Representative papers. 1988 Contraception pmid:3370985
Liu GZ et al. Effects of K salt or a potassium blocker on gossypol-related hypokalemia. 1988 Contraception pmid:3370986
Frick J et al. Clinical microdose study of gossypol: effect on sperm motility and renal function. 1988 Contraception pmid:3370988
Drayer DE and Reidenberg MM Gossypol and Na+, K+ ATPase from human erythrocytes. 1988 Contraception pmid:2848657
Xue SP et al. Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. 1988 Contraception pmid:3370989
Beaudoin AR A developmental toxicity evaluation of gossypol. 1988 Contraception pmid:3370993
Benz C et al. Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy. 1988 Contraception pmid:3370994
Matlin SA et al. Large-scale resolution of gossypol enantiomers for biological evaluation. 1988 Contraception pmid:3370995
Zhou RH and Lin XD Isolation of (-)-gossypol from natural plant. 1988 Contraception pmid:3370996
Ratsula K et al. Vaginal contraception with gossypol: a clinical study. 1983 Contraception pmid:6684533
Yang ZJ et al. Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men. 2004 Contraception pmid:15325889
Lohiya NK et al. Limitations in developing gossypol acetic acid as a male contraceptive. 1990 Contraception pmid:2347196
Kumar M et al. Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. 1997 Contraception pmid:9408707
Wu DF and Reidenberg MM Stereoselective interaction between gossypol and rat plasma. 1990 Contraception pmid:2335102
Lin YC et al. Effect of gossypol on thyroid hormones in young female rats. 1990 Contraception pmid:2335106
Kim I et al. Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. 1987 Contraception pmid:3608484
Sinha Hikim AP and Hoffer AP Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol. 1987 Contraception pmid:3621939
Achedume AC et al. Biochemical studies of the effect of gossypol consumption on cholesterol and residual glucose in fed and protein-energy deficient rats. 1994 Contraception pmid:7813227
Teng CS Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. 1997 Contraception pmid:9013060
Bansode FW Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia). 1994 Contraception pmid:8070265
Kainz P et al. The in vivo effect of gossypol on macromolecular synthesis in rat testis. 1985 Contraception pmid:2419026
Polsky B et al. Inactivation of human immunodeficiency virus in vitro by gossypol. 1989 Contraception pmid:2473865
Bender HS et al. A histopathologic study of the effects of gossypol on the female rat. 1988 Contraception pmid:3197423
Nwoha PU The blood constituents of gossypol-treated, protein-malnourished Wistar rats. 1995 Contraception pmid:8605784
Nwoha PU and Aire TA The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats. 1995 Contraception pmid:8605785
Nwoha PU and Aire TA Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine. 1995 Contraception pmid:8605786
Orhan G et al. The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index. 1993 Contraception pmid:8508667
González-Garza MT et al. Orally administered gossypol has no effect on eight hamster erythrocytic enzymes. 1995 Contraception pmid:8749602
Wang C and Yeung RT Gossypol and hypokalaemia. 1985 Contraception pmid:3910352
Yuan YY and Shi QX Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity. 2000 Contraception pmid:11137075
Zhang SF et al. Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: I. The activity for DNA synthesis. 1989 Contraception pmid:2758843
Ye BK et al. Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: II. The activity for the synthesis of cellular and nuclear basic proteins. 1989 Contraception pmid:2758844
Wang JM et al. The entry of gossypol across the blood-testis barrier in rats. 1989 Contraception pmid:2721201
Wang Y et al. Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. 1985 Contraception pmid:4092462
Wu YM et al. Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. 1981 Contraception pmid:6796329
Gu Y and Anderson NO Effects of gossypol on the estrous cycle and ovarian weight in the rat. 1985 Contraception pmid:4085249
Anuja MN et al. Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative study with gossypol. 2010 Contraception pmid:20851234
Coutinho EM Gossypol: a contraceptive for men. 2002 Contraception pmid:12020773