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Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. |
2008 |
Mol. Cancer Ther. |
pmid:18645028
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Li ZM et al. |
Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin's lymphoma cells. |
2008 |
Cancer Biol. Ther. |
pmid:17938578
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Jia L et al. |
Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. |
2008 |
Cancer Chemother. Pharmacol. |
pmid:17356822
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Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. |
2008 |
Curr. Med. Chem. |
pmid:18220769
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Przybylski P et al. |
EI MS and ESI MS studies of the bisesquiterpene from cotton seeds: Gossypol and its Aza-derivatives. |
2008 |
J Mass Spectrom |
pmid:18200654
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Kitada S et al. |
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). |
2008 |
Blood |
pmid:18202226
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Tang G et al. |
Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins. |
2008 |
J. Med. Chem. |
pmid:18237106
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Kline MP et al. |
R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. |
2008 |
Exp. Hematol. |
pmid:18346839
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Gao F et al. |
Interactive effects of elevated CO2 and cotton cultivar on tri-trophic interaction of Gossypium hirsutum, Aphis gossyppii, and Propylaea japonica. |
2008 |
Environ. Entomol. |
pmid:18348793
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Przybylski P et al. |
CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state. |
2008 |
Magn Reson Chem |
pmid:18338327
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Zha SW et al. |
[Male antifertility drugs and cell apoptosis]. |
2008 |
Zhonghua Nan Ke Xue |
pmid:18297819
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Energy metabolism transition in multi-cellular human tumor spheroids. |
2008 |
J. Cell. Physiol. |
pmid:18264981
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Arnold AA et al. |
Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. |
2008 |
Mol. Cancer |
pmid:18275607
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Sikora MJ et al. |
Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. |
2008 |
Cancer Biol. Ther. |
pmid:18376141
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Dowd MK and Pelitire SM |
HPLC preparation of the chiral forms of 6-methoxy-gossypol and 6,6'-dimethoxy-gossypol. |
2008 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:18407810
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Ojha P et al. |
Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. |
2008 |
Anim. Reprod. Sci. |
pmid:17207942
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Balakrishnan K et al. |
Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. |
2008 |
Blood |
pmid:18566329
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Wang X et al. |
Bioactivities of gossypol, 6-methoxygossypol, and 6,6'-dimethoxygossypol. |
2008 |
J. Agric. Food Chem. |
pmid:18517219
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Johnson PW |
New targets for lymphoma treatment. |
2008 |
Ann. Oncol. |
pmid:18519406
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Marzo I and Naval J |
Bcl-2 family members as molecular targets in cancer therapy. |
2008 |
Biochem. Pharmacol. |
pmid:18638457
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Liu J et al. |
Stereoselective coupling of hemigossypol to form (+)-gossypol in moco cotton is mediated by a dirigent protein. |
2008 |
Phytochemistry |
pmid:18639908
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Villaseñor M et al. |
Gossypol disrupts embryo development in heifers. |
2008 |
J. Dairy Sci. |
pmid:18650278
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Aoyama K |
[Determination of gossypol in feeds by HPLC]. |
2008 |
Shokuhin Eiseigaku Zasshi |
pmid:18787315
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Sun Y et al. |
Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. |
2008 |
Cancer Biol. Ther. |
pmid:18769131
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Zhou DR et al. |
Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of Connexin43. |
2008 |
Toxicol In Vitro |
pmid:18706992
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Trischitta F and Faggio C |
Gossypol affects ion transport in the isolated intestine of the seawater adapted eel, Anguilla anguilla. |
2008 |
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |
pmid:18606239
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Etxebarria A et al. |
Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. |
2008 |
Biochem. Pharmacol. |
pmid:18762177
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Tang Y et al. |
[Progress in small-molecule inhibitors of Bcl-2 family proteins]. |
2008 |
Yao Xue Xue Bao |
pmid:18819468
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Gong YZ et al. |
Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. |
2008 |
Eur. J. Pharmacol. |
pmid:18930721
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Sun J et al. |
ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. |
2008 |
Anticancer Drugs |
pmid:18827561
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Janssen CO et al. |
Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. |
2008 |
Bioorg. Med. Chem. Lett. |
pmid:18845435
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Mi JX et al. |
Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. |
2008 |
Acta Pharmacol. Sin. |
pmid:19026166
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Stipanovic RD et al. |
Effect of racemic, (+)- and (-)-gossypol on survival and development of Heliothis virescens larvae. |
2008 |
Environ. Entomol. |
pmid:19036185
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Karaca B et al. |
Profiling of angiogenic cytokines produced by hormone- and drug-refractory prostate cancer cell lines, PC-3 and DU-145 before and after treatment with gossypol. |
2008 |
Eur. Cytokine Netw. |
pmid:19103523
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Macoska JA et al. |
-(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro. |
2008 Nov-Dec |
Pharmacol. Res. |
pmid:18840529
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Sheweita SA et al. |
N-Nitrosodimethylamine changes the expression of glutathione S-transferase in the liver of male mice: The role of antioxidants. |
2008 Nov-Dec |
J. Biochem. Mol. Toxicol. |
pmid:19111000
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Zhai G et al. |
A liposomal delivery vehicle for the anticancer agent gossypol. |
2008 Sep-Oct |
Anticancer Res. |
pmid:19035313
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Kang MH and Reynolds CP |
Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. |
2009 |
Clin. Cancer Res. |
pmid:19228717
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Lin J et al. |
[Effect of apogossypolone on induction apoptosis in multiple myeloma cells and its mechanisms]. |
2009 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:19236755
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Przybylski P et al. |
Complexes of heterocyclic aza-derivatives of phytoalexin from cotton plant-gossypol with alkali metal cations and perchlorate anion studied by ESI mass spectrometric method in the positive and negative modes. |
2009 |
J Mass Spectrom |
pmid:19189269
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Przybylski P et al. |
Antifungal activity of alkyl and heterocyclic aza-derivatives of gossypol as well as their complexes with NaClO4 against Fusarium oxysporum f. sp. lupini. |
2009 |
Bioorg. Med. Chem. Lett. |
pmid:19264482
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Przybylski P et al. |
Synthesis, crystal structures and antibacterial activity studies of aza-derivatives of phytoalexin from cotton plant--gossypol. |
2009 |
Eur J Med Chem |
pmid:19577825
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Wei J et al. |
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. |
2009 |
J. Med. Chem. |
pmid:19555126
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Lestini BJ et al. |
Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. |
2009 |
Cancer Biol. Ther. |
pmid:19556859
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Ionov M et al. |
The immobilization of gossypol derivative on N-polyvinylpyrrolidone increases its water solubility and modifies membrane-active properties. |
2009 |
J. Med. Chem. |
pmid:19603832
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Anilkumar KJ et al. |
Synergistic interactions between Cry1Ac and natural cotton defenses limit survival of Cry1Ac-resistant Helicoverpa zea (Lepidoptera: Noctuidae) on Bt cotton. |
2009 |
J. Chem. Ecol. |
pmid:19588197
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Huang YW et al. |
(-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. |
2009 |
Anticancer Res. |
pmid:19528479
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Yurekli B et al. |
Can gossypol be a hope for transsexual patients (male to female) before sex reassignment surgery? Just for adjusting the body to mind. |
2009 |
Med. Hypotheses |
pmid:19647947
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Roychoudhury S et al. |
In vitro gossypol induced spermatozoa motility alterations in rabbits. |
2009 |
J Environ Sci Health B |
pmid:20183084
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Wang WQ et al. |
[Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. |
2009 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:20030926
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