| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Darier Disease | D007644 | 2 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Myxosarcoma | D009236 | 1 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jensen EC et al. | Lipoxygenase inhibitors shift the yeast/mycelium dimorphism in Ceratocystis ulmi. | 1992 | Appl. Environ. Microbiol. | pmid:1514797 |
| Zhou M et al. | Metabolic engineering of gossypol in cotton. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23775273 |
| Ahmed AA et al. | Gossypol as anti-fertility agent in female rats. | 1988 | Arch Exp Veterinarmed | pmid:3219036 |
| Leal-Garza CH et al. | [Frequency of sister chromatid exchange in mice treated with gossypol]. | 1990 Jul-Sep | Arch Invest Med (Mex) | pmid:2131768 |
| Bressani R et al. | [Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum]. | 1975 | Arch Latinoam Nutr | pmid:1174302 |
| Mayorga H et al. | [Extraction and precipitation of cottonseed protein by the wet method]. | 1973 | Arch Latinoam Nutr | pmid:4801265 |
| Braham JE et al. | [Gossypol absorption in rats and in pigs]. | 1971 | Arch Latinoam Nutr | pmid:5172839 |
| Rolz C et al. | [Method of wet concentration of protein of cotton seed cake processed by screw press]. | 1971 | Arch Latinoam Nutr | pmid:5172841 |
| Hoffer AP | Ultrastructural studies of spermatozoa and the epithelial lining of the epididymis and vas deferens in rats treated with gossypol. | 1982 | Arch. Androl. | pmid:7114955 |
| Cui G et al. | Gossypol with methyltestosterone and ethinylestradiol male does not affect rat spermatogonial stem cell differentiation. | 2007 Mar-Apr | Arch. Androl. | pmid:17453689 |
| Tso WW and Lee CS | Effect of gossypol on boar spermatozoa in vitro. | 1981 | Arch. Androl. | pmid:7271366 |
| Liu YX | Control of spermatogenesis in primate and prospect of male contraception. | 2005 Mar-Apr | Arch. Androl. | pmid:15804862 |
| Engler SJ et al. | Absence of histopathology in somatic tissues of rats made infertile with gossypol. | 1984 | Arch. Androl. | pmid:6534283 |
| Bhargava SK | Semen characteristics of gossypol-treated langurs (Presbytis entellus entellus Dufresne). | 1984 | Arch. Androl. | pmid:6537746 |
| Herrera J et al. | Cottonseed flour effects on androgen testicular content and serum levels in rats. | 1983 | Arch. Androl. | pmid:6688944 |
| Herrera J et al. | Modifications in the testis steroidogenic pathways in rats fed with cottonseed flour. | 1984 | Arch. Androl. | pmid:6236762 |
| Tso WW and Lee CS | Cottonseed oil as a vaginal contraceptive. | 1982 | Arch. Androl. | pmid:6895984 |
| Tso WW et al. | Effect of gossypol on boar spermatozoal adenosine triphosphate metabolism. | 1982 | Arch. Androl. | pmid:6219642 |
| Placzek R et al. | Effect of ace-inhibitors, calmodulin antagonists, acetylcholine receptor blocking, and alpha receptor blocking agents on motility of human sperm. | 1988 | Arch. Androl. | pmid:2903725 |
| Male fertility and its regulation: expanded abstracts. International symposium, Maui, Hawaii, October 9-15, 1982. | 1982 | Arch. Androl. | pmid:6812518 | |
| Tso WW and Lee CS | Gossypol: an effective acrosin blocker. | 1982 | Arch. Androl. | pmid:6803693 |
| CONKERTON EJ and FRAMPTON VL | Reaction of gossypol with free epsilon-amino groups of lysine in proteins. | 1959 | Arch. Biochem. Biophys. | pmid:13637974 |
| LYMAN CM et al. | Reactions of proteins with gossypol. | 1959 | Arch. Biochem. Biophys. | pmid:14419129 |
| CASTILLON LE et al. | Preparation of combination products of gossypol with glycine and dextrose and their toxicity toward mice. | 1953 | Arch. Biochem. Biophys. | pmid:13058367 |
| Hou DX et al. | Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis. | 2004 | Arch. Biochem. Biophys. | pmid:15246875 |
| Olgiati KL et al. | Gossypol inhibition of adenylate cyclase. | 1984 | Arch. Biochem. Biophys. | pmid:6732240 |
| Singh SK and Rath SK | Histologic changes in the mouse testis after treatment with gossypol tetra-acetic acid. | 1990 | Arch. Histol. Cytol. | pmid:2268474 |
| González-Garza MT et al. | Further studies on the in vitro activity of gossypol as antiamebic agent. | 1992 | Arch. Med. Res. | pmid:1340324 |
| González-Garza MT et al. | Gossypol anti-amebic effect in vivo. | 1997 | Arch. Med. Res. | pmid:9033108 |
| Cruz-Vega DE et al. | Determination of the antiamebic effect of a metronidazole/gossypol blend. | 1997 | Arch. Med. Res. | pmid:9033109 |
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| Aneja R et al. | Effect of gossypol in association with chromium protoporphyrin on heme metabolic enzymes. | 2004 | Artif Cells Blood Substit Immobil Biotechnol | pmid:15027808 |
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| Gu ZP et al. | Low dose gossypol for male contraception. | 2000 | Asian J. Androl. | pmid:11202417 |
| Zhang XQ et al. | Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro. | 2010 | Asian J. Androl. | pmid:20657602 |
| D'Cruz SC et al. | Effects of plants and plant products on the testis. | 2010 | Asian J. Androl. | pmid:20562897 |
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| Lian J et al. | The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells. | 2010 | Autophagy | pmid:20930561 |
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| de Peyster A et al. | Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6322752 |
| Olgiati KL and Toscano WA | Kinetics of gossypol inhibition of bovine lactate dehydrogenase X. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6615526 |