Azmi AS and Mohammad RM |
Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. |
2009 |
J. Cell. Physiol. |
pmid:18767026
|
Kang MH and Reynolds CP |
Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. |
2009 |
Clin. Cancer Res. |
pmid:19228717
|
Lin J et al. |
[Effect of apogossypolone on induction apoptosis in multiple myeloma cells and its mechanisms]. |
2009 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:19236755
|
Przybylski P et al. |
Complexes of heterocyclic aza-derivatives of phytoalexin from cotton plant-gossypol with alkali metal cations and perchlorate anion studied by ESI mass spectrometric method in the positive and negative modes. |
2009 |
J Mass Spectrom |
pmid:19189269
|
Przybylski P et al. |
Antifungal activity of alkyl and heterocyclic aza-derivatives of gossypol as well as their complexes with NaClO4 against Fusarium oxysporum f. sp. lupini. |
2009 |
Bioorg. Med. Chem. Lett. |
pmid:19264482
|
Balakrishnan K et al. |
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. |
2009 |
Blood |
pmid:18836097
|
Liu G et al. |
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. |
2009 |
Clin. Cancer Res. |
pmid:19366825
|
Jiang J et al. |
Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFbeta/Akt signaling. |
2009 |
Int. J. Mol. Med. |
pmid:19513537
|
Przybylski P et al. |
Synthesis, crystal structures and antibacterial activity studies of aza-derivatives of phytoalexin from cotton plant--gossypol. |
2009 |
Eur J Med Chem |
pmid:19577825
|
Wei J et al. |
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. |
2009 |
J. Med. Chem. |
pmid:19555126
|
Lestini BJ et al. |
Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. |
2009 |
Cancer Biol. Ther. |
pmid:19556859
|
Ionov M et al. |
The immobilization of gossypol derivative on N-polyvinylpyrrolidone increases its water solubility and modifies membrane-active properties. |
2009 |
J. Med. Chem. |
pmid:19603832
|
Anilkumar KJ et al. |
Synergistic interactions between Cry1Ac and natural cotton defenses limit survival of Cry1Ac-resistant Helicoverpa zea (Lepidoptera: Noctuidae) on Bt cotton. |
2009 |
J. Chem. Ecol. |
pmid:19588197
|
Huang YW et al. |
(-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. |
2009 |
Anticancer Res. |
pmid:19528479
|
Yurekli B et al. |
Can gossypol be a hope for transsexual patients (male to female) before sex reassignment surgery? Just for adjusting the body to mind. |
2009 |
Med. Hypotheses |
pmid:19647947
|
El-Sharaky AS et al. |
Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. |
2009 |
Food Chem. Toxicol. |
pmid:19665044
|
Hu GX et al. |
The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes. |
2009 |
J. Steroid Biochem. Mol. Biol. |
pmid:19429456
|
Barba-Barajas M et al. |
Gossypol induced apoptosis of polymorphonuclear leukocytes and monocytes: involvement of mitochondrial pathway and reactive oxygen species. |
2009 |
Immunopharmacol Immunotoxicol |
pmid:19235535
|
Basini G et al. |
Gossypol, a polyphenolic aldehyde from cotton plant, interferes with swine granulosa cell function. |
2009 |
Domest. Anim. Endocrinol. |
pmid:19342192
|
Roychoudhury S et al. |
In vitro gossypol induced spermatozoa motility alterations in rabbits. |
2009 |
J Environ Sci Health B |
pmid:20183084
|
Wang WQ et al. |
[Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. |
2009 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:20030926
|
Xu P et al. |
Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. |
2009 |
Anticancer Res. |
pmid:20032412
|
Cheng W et al. |
[Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line]. |
2009 |
Zhongguo Yi Xue Ke Xue Yuan Xue Bao |
pmid:19968063
|
Pérez A et al. |
Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol. |
2009 |
Am. J. Physiol., Cell Physiol. |
pmid:19386788
|
Zhai G et al. |
A liposomal delivery vehicle for the anticancer agent gossypol. |
2008 Sep-Oct |
Anticancer Res. |
pmid:19035313
|
Macoska JA et al. |
-(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro. |
2008 Nov-Dec |
Pharmacol. Res. |
pmid:18840529
|
Sheweita SA et al. |
N-Nitrosodimethylamine changes the expression of glutathione S-transferase in the liver of male mice: The role of antioxidants. |
2008 Nov-Dec |
J. Biochem. Mol. Toxicol. |
pmid:19111000
|
Meng Y et al. |
Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. |
2008 |
Mol. Cancer Ther. |
pmid:18645028
|
Brozic P et al. |
Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. |
2008 |
Curr. Med. Chem. |
pmid:18220769
|
Przybylski P et al. |
EI MS and ESI MS studies of the bisesquiterpene from cotton seeds: Gossypol and its Aza-derivatives. |
2008 |
J Mass Spectrom |
pmid:18200654
|
Kitada S et al. |
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). |
2008 |
Blood |
pmid:18202226
|
Tang G et al. |
Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins. |
2008 |
J. Med. Chem. |
pmid:18237106
|
Kline MP et al. |
R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. |
2008 |
Exp. Hematol. |
pmid:18346839
|
Gao F et al. |
Interactive effects of elevated CO2 and cotton cultivar on tri-trophic interaction of Gossypium hirsutum, Aphis gossyppii, and Propylaea japonica. |
2008 |
Environ. Entomol. |
pmid:18348793
|
Moon DO et al. |
Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells. |
2008 |
Cancer Lett. |
pmid:18314260
|
Sprogøe K et al. |
Combining HPLC-PDA-MS-SPE-NMR with circular dichroism for complete natural product characterization in crude extracts: levorotatory gossypol in Thespesia danis. |
2008 |
J. Nat. Prod. |
pmid:18290629
|
Ojha P et al. |
Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. |
2008 |
Anim. Reprod. Sci. |
pmid:17207942
|
Balakrishnan K et al. |
Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. |
2008 |
Blood |
pmid:18566329
|
Wang X et al. |
Bioactivities of gossypol, 6-methoxygossypol, and 6,6'-dimethoxygossypol. |
2008 |
J. Agric. Food Chem. |
pmid:18517219
|
Johnson PW |
New targets for lymphoma treatment. |
2008 |
Ann. Oncol. |
pmid:18519406
|
Marzo I and Naval J |
Bcl-2 family members as molecular targets in cancer therapy. |
2008 |
Biochem. Pharmacol. |
pmid:18638457
|
Liu J et al. |
Stereoselective coupling of hemigossypol to form (+)-gossypol in moco cotton is mediated by a dirigent protein. |
2008 |
Phytochemistry |
pmid:18639908
|
Villaseñor M et al. |
Gossypol disrupts embryo development in heifers. |
2008 |
J. Dairy Sci. |
pmid:18650278
|
Aoyama K |
[Determination of gossypol in feeds by HPLC]. |
2008 |
Shokuhin Eiseigaku Zasshi |
pmid:18787315
|
Sun Y et al. |
Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. |
2008 |
Cancer Biol. Ther. |
pmid:18769131
|
Moon DO et al. |
Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. |
2008 |
FEBS Lett. |
pmid:18775705
|
Przybylski P et al. |
Molecular structures and stability constants of gossypol and its aza-derivative complexes with silver(I) cations studied by potentiometric, ESI MS, NMR, and AM1d semiempirical methods. |
2008 |
J Phys Chem A |
pmid:18698745
|
Mi JX et al. |
Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. |
2008 |
Acta Pharmacol. Sin. |
pmid:19026166
|
Stipanovic RD et al. |
Effect of racemic, (+)- and (-)-gossypol on survival and development of Heliothis virescens larvae. |
2008 |
Environ. Entomol. |
pmid:19036185
|
Karaca B et al. |
Profiling of angiogenic cytokines produced by hormone- and drug-refractory prostate cancer cell lines, PC-3 and DU-145 before and after treatment with gossypol. |
2008 |
Eur. Cytokine Netw. |
pmid:19103523
|