MeSH term | MeSH ID | Detail |
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Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
Myxosarcoma | D009236 | 1 associated lipids |
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ye W et al. | Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. | 2007 Jan-Feb | Anticancer Res. | pmid:17352222 |
Meng Y et al. | (-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. | 2007 | Leuk. Lymphoma | pmid:17926190 |
Mao YB et al. | Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. | 2007 | Nat. Biotechnol. | pmid:17982444 |
Lordelo MM et al. | Relative toxicity of gossypol enantiomers in laying and broiler breeder hens. | 2007 | Poult. Sci. | pmid:17297172 |
Zhang M et al. | Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. | 2007 | Clin. Exp. Pharmacol. Physiol. | pmid:17250644 |
Leyman A et al. | The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts. | 2007 | Cell. Signal. | pmid:17355905 |
Costantino A et al. | Current status and future perspectives in male contraception. | 2007 | Minerva Ginecol | pmid:17576406 |
Tang G et al. | Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. | 2007 | J. Med. Chem. | pmid:17552510 |
Ko CH et al. | Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. | 2007 | Int. J. Cancer | pmid:17597109 |
Wolter KG et al. | Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins. | 2007 | Cell Death Differ. | pmid:17541428 |
Kasten-Pisula U et al. | Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. | 2007 | Radiother Oncol | pmid:17521756 |
Feng BY et al. | A high-throughput screen for aggregation-based inhibition in a large compound library. | 2007 | J. Med. Chem. | pmid:17447748 |
Badawy SZ et al. | Gossypol inhibits proliferation of endometrioma cells in culture. | 2007 | Asian J. Androl. | pmid:17486280 |
Orth RG et al. | Determining larval host plant use by a polyphagous lepidopteran through analysis of adult moths for plant secondary metabolites. | 2007 | J. Chem. Ecol. | pmid:17492366 |
Carruthers NJ et al. | Gossypol inhibits calcineurin phosphatase activity at multiple sites. | 2007 | Eur. J. Pharmacol. | pmid:17141216 |
Liu F et al. | Pharmacophore identification of KSP inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17095225 |
Zhang M et al. | Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways. | 2007 | Life Sci. | pmid:17156797 |
Song JJ et al. | Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. | 2007 | J. Biol. Chem. | pmid:17110373 |
Denisov AY et al. | Heat-induced dimerization of BCL-xL through alpha-helix swapping. | 2007 | Biochemistry | pmid:17223694 |
Makkar HP et al. | Plant secondary metabolites. | 2007 | Methods Mol. Biol. | pmid:19238775 |