Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Leukemia, Biphenotypic, Acute D015456 2 associated lipids
Myxosarcoma D009236 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Han ZY [Relationship between eating cotton-seed oil and blood potassium levels]. 1988 Zhonghua Yu Fang Yi Xue Za Zhi pmid:3219964
Huang TH [The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells]. 1983 Zhonghua Yi Xue Za Zhi pmid:6407739
Sun TS [Long-term follow-up studies on patients poisoned by cottonseed oil]. 1986 Zhonghua Yi Xue Za Zhi pmid:3091216
Liu GZ [Clinical trial of gossypol as a male contraceptive: a randomized controlled study]. 1985 Zhonghua Yi Xue Za Zhi pmid:3921206
Zhang LS [Effect of gossypol on serum gonadotropin and testosterone levels: long-term follow-up study]. 1985 Zhonghua Yi Xue Za Zhi pmid:3931874
Hei LS [Electron-microscopic observations on bioptic testicular tissue of cancerous patients after oral administration of gossypol (author's transl)]. 1981 Zhonghua Yi Xue Za Zhi pmid:6804060
Gao H et al. [Primary observations on distal renal tubule acidosis in 177 cases caused by gossypol intoxication]. 1985 Zhonghua Nei Ke Za Zhi pmid:4053804
Zhou DR et al. [Gossypol decreases the expression of connexin 43 in Sertoli cells]. 2011 Zhonghua Nan Ke Xue pmid:22141269
Zha SW et al. [Male antifertility drugs and cell apoptosis]. 2008 Zhonghua Nan Ke Xue pmid:18297819
Fan LP et al. [Emergency treatment and care of hypokalemia paralysis due to gossypol poisoning]. 1995 Zhonghua Hu Li Za Zhi pmid:8716068
Liu YX [The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)]. 1981 Zhonghua Fu Chan Ke Za Zhi pmid:7327032
[A preliminary study on gossypol used in gynecology and its mechanism of action (author's transl)]. 1981 Zhonghua Fu Chan Ke Za Zhi pmid:7327033
Zhou SW [Clinical use of gossypol in gynecology (author's transl)]. 1981 Zhonghua Fu Chan Ke Za Zhi pmid:7327034
Zhou SW [Clinical experience with a gossypol-releasing IUD]. 1988 Zhonghua Fu Chan Ke Za Zhi pmid:3058417
Zhu PD [Electron microscopic observations on the effect of gossypol on the human endometrium]. 1984 Zhonghua Fu Chan Ke Za Zhi pmid:6536444
Zhang YW et al. [Estrogen and progesterone cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy]. 1994 Zhonghua Fu Chan Ke Za Zhi pmid:8082445
YU TW [Ultrastructural study of the testis in 22 persons based on the effect of gossypol]. 1987 Zhonghua Bing Li Xue Za Zhi pmid:2957085
Cui GH et al. [Determination of gossypol in cotton root bark by HPLC]. 2002 Zhongguo Zhong Yao Za Zhi pmid:12774395
Zhang SC et al. [The adverse effects of the preparations of the active principles of Chinese herbal drugs]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8267848
Huang HF and Wang M [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells]. 1994 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:8000225