| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myxosarcoma | D009236 | 1 associated lipids |
| Darier Disease | D007644 | 2 associated lipids |
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Genital Neoplasms, Male | D005834 | 3 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
| Protein Deficiency | D011488 | 5 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Medrano FJ and Andreu JM | Binding of gossypol to purified tubulin and inhibition of its assembly into microtubules. | 1986 | Eur. J. Biochem. | pmid:3732269 |
| Tripathi AK et al. | An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme. | 2004 | Eur. J. Biochem. | pmid:15317584 |
| Karaca B et al. | Profiling of angiogenic cytokines produced by hormone- and drug-refractory prostate cancer cell lines, PC-3 and DU-145 before and after treatment with gossypol. | 2008 | Eur. Cytokine Netw. | pmid:19103523 |
| Atmaca H et al. | Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells. | 2009 | Eur. Cytokine Netw. | pmid:19825521 |
| Zubair H et al. | Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage. | 2012 | Eur J Pharm Sci | pmid:22554693 |
| Dao VT et al. | Synthesis and cytotoxicity of gossypol related compounds. | 2000 | Eur J Med Chem | pmid:11006482 |
| Dao VT et al. | Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone. | 2004 | Eur J Med Chem | pmid:15236842 |
| El-Nassan HB | Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. | 2013 | Eur J Med Chem | pmid:23434636 |
| Zhang L et al. | Chiral gossypol derivatives: evaluation of their anticancer activity and molecular modeling. | 2009 | Eur J Med Chem | pmid:19447525 |
| Przybylski P et al. | Synthesis, crystal structures and antibacterial activity studies of aza-derivatives of phytoalexin from cotton plant--gossypol. | 2009 | Eur J Med Chem | pmid:19577825 |
| Zhang Z et al. | Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach. | 2013 | Eur J Med Chem | pmid:23220642 |
| Zhang Z et al. | Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking. | 2013 | Eur J Med Chem | pmid:24095762 |
| Zhang Z et al. | Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors. | 2013 | Eur J Med Chem | pmid:23314054 |
| Akinola OB et al. | Proteinaceous diet inhibits gossypol-induced spermatotoxicity. | 2006 Jul-Sep | Eur J Histochem | pmid:16920644 |
| Aneja R et al. | Modulatory influence of tin-protoporphyrin on gossypol-induced alterations of heme oxygenase activity in male Wistar rats. | 2003 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:14527098 |
| Liang JC and Ye WS | Clastogenicity of a male contraceptive, gossypol, in mammalian cell cultures with and without the metabolic activation by S9 mix. | 1985 | Environ. Res. | pmid:3967635 |
| Majumdar SK et al. | Genotoxic effects of gossypol acetic acid on cultured murine erythroleukemia cells. | 1991 | Environ. Mol. Mutagen. | pmid:1915316 |
| Gao F et al. | Interactive effects of elevated CO2 and cotton cultivar on tri-trophic interaction of Gossypium hirsutum, Aphis gossyppii, and Propylaea japonica. | 2008 | Environ. Entomol. | pmid:18348793 |
| Stipanovic RD et al. | Effect of racemic, (+)- and (-)-gossypol on survival and development of Heliothis virescens larvae. | 2008 | Environ. Entomol. | pmid:19036185 |
| Colman N et al. | Non-mutagenicity of gossypol in the Salmonella/mammalian-microsome plate assay. | 1979 | Environ Mutagen | pmid:399915 |
| Sabirova FM et al. | [Immunomodulating effect of the novel water-soluble gossypol derivative Mebavin in adjuvant arthritis]. | 2004 Mar-Apr | Eksp Klin Farmakol | pmid:15188763 |
| Sabirova FM and Madaminov AA | [Anti-inflammatory activity of the novel water soluble gossipol derivative mebavine]. | 2003 Nov-Dec | Eksp Klin Farmakol | pmid:14743712 |
| Suzuki H et al. | [Studies on naturally occurring toxic substances (III). Determination of gossypol in seed kernels of cotton plants by high performance liquid chromatography]. | 1986 | Eisei Shikenjo Hokoku | pmid:3567428 |
| Gombe S | A review of the current status in male contraceptive studies. | 1983 | East Afr Med J | pmid:6354690 |
| Matlin SA | Prospects for pharmacological male contraception. | 1994 | Drugs | pmid:7533693 |
| Wu D | An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. | 1989 | Drugs | pmid:2680434 |
| Ren T et al. | Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer. | 2015 | Drug Des Devel Ther | pmid:26089640 |
| Ren T et al. | Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. | 2014 | Drug Des Devel Ther | pmid:25548514 |
| Qian C et al. | Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor. | 2014 | Drug Des Devel Ther | pmid:24872679 |
| Reynolds JM and Tone JN | Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats. | 1988 | Drug Chem Toxicol | pmid:3402348 |
| Tone JN and Jensen DR | Radioiron utilization and gossypol acetic acid in male rats. | 1985 | Drug Chem Toxicol | pmid:4017900 |
| Lagerlöf RK and Tone JN | The effect of gossypol acetic acid on female reproduction. | 1985 | Drug Chem Toxicol | pmid:4092619 |
| Basini G et al. | Gossypol, a polyphenolic aldehyde from cotton plant, interferes with swine granulosa cell function. | 2009 | Domest. Anim. Endocrinol. | pmid:19342192 |
| Aripov UA et al. | [Immunodepressive properties of the drug "Batriden" in experiments on parabionts]. | 1975 | Dokl. Akad. Nauk SSSR | pmid:1140070 |
| Krasil'nikov OV et al. | [Dependence of the protonophore and channel-forming capacity of gossypol on the pH]. | 1985 | Dokl. Akad. Nauk SSSR | pmid:2408838 |
| Graier WF et al. | High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions. | 1996 | Diabetes | pmid:8826976 |
| VISWESWARA RAO K and VASUDEVA SARMA R | Occurrence of gossypol. | 1945 | Curr. Sci. | pmid:21007609 |
| Brozic P et al. | Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. | 2008 | Curr. Med. Chem. | pmid:18220769 |
| Kawanishi K et al. | Aldose reductase inhibitors from the nature. | 2003 | Curr. Med. Chem. | pmid:12871134 |
| Vander Jagt DL et al. | Gossypol: prototype of inhibitors targeted to dinucleotide folds. | 2000 | Curr. Med. Chem. | pmid:10702620 |
| Kovacic P | Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. | 2003 | Curr. Med. Chem. | pmid:14529461 |
| Bodur C and Basaga H | Bcl-2 inhibitors: emerging drugs in cancer therapy. | 2012 | Curr. Med. Chem. | pmid:22414090 |
| Jensen JT | Male contraception. | 2002 | Curr Womens Health Rep | pmid:12215306 |
| Verma PC et al. | Efficient production of gossypol from hairy root cultures of cotton (Gossypium hirsutum L.). | 2009 | Curr Pharm Biotechnol | pmid:19751178 |
| Han ML et al. | Gossypol in the treatment of endometriosis and uterine myoma. | 1987 | Contrib Gynecol Obstet | pmid:3121251 |
| Srivastava A et al. | Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. | 1989 | Contraception | pmid:2469550 |
| Moore GD et al. | Inhibition of sperm migration, fertilization and implantation in rats by precoital intrauterine administration of gossypol or nonoxynol-9. | 1988 | Contraception | pmid:2835205 |
| Lan ZJ et al. | Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells. | 1992 | Contraception | pmid:1511610 |
| Tang F et al. | Inhibition of catechol-O-methyltransferase by gossypol: the effect of plasma proteins. | 1982 | Contraception | pmid:7160182 |
| Giridharan N et al. | Inhibition of rat testis LDH-X activity by gossypol. | 1982 | Contraception | pmid:7168954 |
| Hahn DW et al. | Antifertility and endocrine activities of gossypol in rodents. | 1981 | Contraception | pmid:7273769 |
| Waller DP et al. | Antifertility effects of gossypol and its impurities on male hamsters. | 1981 | Contraception | pmid:7285581 |
| Chang MC et al. | Effects of Gossypol on the fertility of male rats, hamsters and rabbits. | 1980 | Contraception | pmid:7428357 |
| Sakesena SK et al. | Gossypol: its toxicological and endocrinological effects in male rabbits. | 1981 | Contraception | pmid:7297071 |
| Tanphaichitr N and Fitzgerald LM | Adverse effects of gossypol analogs on TM4 cell mitochondrial function. | 1989 | Contraception | pmid:2752754 |
| Tanphaichitr N et al. | Inhibitory effects of gossypol analogs on human sperm motility. | 1989 | Contraception | pmid:2752755 |
| Ojha P et al. | Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. | 2006 | Contraception | pmid:16371305 |
| Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. V. Inhibition and recovery of microtubular dynein. | 1995 | Contraception | pmid:7628207 |
| Wichmann K et al. | Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism. | 1986 | Contraception | pmid:3757514 |
| Paz GF and Homonnai ZT | Effect of the antifertility agent, gossypol acetic acid, on the metabolism and testosterone secretion of isolated rat interstitial cells in vitro. | 1984 | Contraception | pmid:6467943 |
| International Symposium on Gossypol Research for Fertility Regulation. Wuhan, China, 15-17 October 1986. Representative papers. | 1988 | Contraception | pmid:3370985 | |
| Zhong CQ et al. | Study on sperm function in men long after cessation of gossypol treatment. | 1990 | Contraception | pmid:2113849 |
| Liu GZ et al. | Effects of K salt or a potassium blocker on gossypol-related hypokalemia. | 1988 | Contraception | pmid:3370986 |
| Frick J et al. | Clinical microdose study of gossypol: effect on sperm motility and renal function. | 1988 | Contraception | pmid:3370988 |
| Drayer DE and Reidenberg MM | Gossypol and Na+, K+ ATPase from human erythrocytes. | 1988 | Contraception | pmid:2848657 |
| Xue SP et al. | Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. | 1988 | Contraception | pmid:3370989 |
| Johansen RL and Misra HP | Effects of gossypol on the hepatic drug metabolizing system in rats. | 1990 | Contraception | pmid:2083490 |
| Yang ZJ et al. | Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men. | 2004 | Contraception | pmid:15325889 |
| Kim IC et al. | Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone. | 1984 | Contraception | pmid:6509980 |
| Tso WW and Lee CS | Gossypol uncoupling of respiratory chain and oxidative phosphorylation in ejaculated boar spermatozoa. | 1982 | Contraception | pmid:6889482 |
| Lohiya NK et al. | Limitations in developing gossypol acetic acid as a male contraceptive. | 1990 | Contraception | pmid:2347196 |
| Kumar M et al. | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. | 1997 | Contraception | pmid:9408707 |
| Kalla NR et al. | Involvement of prostaglandin in the antifertility effects of gossypol. | 1986 | Contraception | pmid:3465506 |
| Wu DF and Reidenberg MM | Stereoselective interaction between gossypol and rat plasma. | 1990 | Contraception | pmid:2335102 |
| Lin YC et al. | Effect of gossypol on thyroid hormones in young female rats. | 1990 | Contraception | pmid:2335106 |
| Kim I et al. | Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. | 1987 | Contraception | pmid:3608484 |
| Achedume AC et al. | Biochemical studies of the effect of gossypol consumption on cholesterol and residual glucose in fed and protein-energy deficient rats. | 1994 | Contraception | pmid:7813227 |
| Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9115008 |
| Chongthammakun S et al. | Effects of gossypol on human and monkey sperm motility in vitro. | 1986 | Contraception | pmid:3791997 |
| Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9013060 |
| Wu D and Reidenberg MM | Effect of potassium deficiency and gossypol on urinary N-acetyl-beta-glucosaminidase excretion in the rat. | 1993 | Contraception | pmid:8275698 |
| Kainz P et al. | The in vivo effect of gossypol on macromolecular synthesis in rat testis. | 1985 | Contraception | pmid:2419026 |
| Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. IV. The activity for the modification of core histones. | 1993 | Contraception | pmid:8403913 |
| Polsky B et al. | Inactivation of human immunodeficiency virus in vitro by gossypol. | 1989 | Contraception | pmid:2473865 |
| Bender HS et al. | A histopathologic study of the effects of gossypol on the female rat. | 1988 | Contraception | pmid:3197423 |
| Nwoha PU | The blood constituents of gossypol-treated, protein-malnourished Wistar rats. | 1995 | Contraception | pmid:8605784 |
| Nwoha PU and Aire TA | The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats. | 1995 | Contraception | pmid:8605785 |
| Nwoha PU and Aire TA | Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine. | 1995 | Contraception | pmid:8605786 |
| Orhan G et al. | The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index. | 1993 | Contraception | pmid:8508667 |
| Teng CS and Vilagrasa X | Biphasic c-Myc protein expression during gossypol-induced apoptosis in rat spermatocytes. | 1998 | Contraception | pmid:9589839 |
| Teng CS | c-fos protein expression in apoptotic rat spermatocytes induced by gossypol. | 1998 | Contraception | pmid:9649921 |
| Zhang SF et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: I. The activity for DNA synthesis. | 1989 | Contraception | pmid:2758843 |
| Ye BK et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: II. The activity for the synthesis of cellular and nuclear basic proteins. | 1989 | Contraception | pmid:2758844 |
| Wong PY et al. | Gossypol does not affect testicular fluid secretion in rats. | 1984 | Contraception | pmid:6744863 |
| Wang JM et al. | The entry of gossypol across the blood-testis barrier in rats. | 1989 | Contraception | pmid:2721201 |
| Wang Y et al. | Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. | 1985 | Contraception | pmid:4092462 |
| Wu YM et al. | Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. | 1981 | Contraception | pmid:6796329 |
| Pearce S et al. | The viability of mouse Leydig cells in vitro following incubation with gossypol. | 1985 | Contraception | pmid:4085245 |
| Gu Y and Anderson NO | Effects of gossypol on the estrous cycle and ovarian weight in the rat. | 1985 | Contraception | pmid:4085249 |
| Anuja MN et al. | Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative study with gossypol. | 2010 | Contraception | pmid:20851234 |