| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myxosarcoma | D009236 | 1 associated lipids |
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Darier Disease | D007644 | 2 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Genital Neoplasms, Male | D005834 | 3 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
| Protein Deficiency | D011488 | 5 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Den Boer PJ and Grootegoed JA | Differential effects of (+)- and (-)-gossypol enantiomers on LDH-C4 activity of hamster spermatogenic epithelium in vitro. | 1988 | J. Reprod. Fertil. | pmid:3411560 |
| Rikihisa Y and Lin YC | Ultrastructure of the testis and epididymis of Japanese quail (Coturnix coturnix japonica) administered gossypol. | 1988 | Poult. Sci. | pmid:3413024 |
| Zhao Y et al. | Studies on frequencies of sister chromatid exchange in peripheral blood lymphocytes before and after gossypol treatment. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3422992 |
| Liu GZ et al. | Effect of K salt and K sparing agent in preventing gossypol-induced hypokalemia. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423005 |
| Cheng JX et al. | Effect of gossypol(+/-, +, -) on Leydig cells of rat in vitro. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423013 |
| Zhang JB et al. | Effect of gossypol on fertilization capacity and chromosome formation of human sperm in vitro. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432238 |
| Ye WS et al. | Cytological toxicity of gossypol on rat gametogenesis and spermatozoa. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432239 |
| Lin YC et al. | Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats. | 1987 | Contraception | pmid:3447817 |
| Guo ZM et al. | [Synthesis of mono-aldehyde gossypol and its analogues]. | 1987 | Yao Xue Xue Bao | pmid:3450164 |
| Zhou RH and Lin XD | [Isolation of (-)-gossypol from natural plant]. | 1987 | Yao Xue Xue Bao | pmid:3450165 |
| Xu Y et al. | [The effect of combined use of gossypol and tripterygium wilfordii on the fertility of male rats]. | 1987 | Yao Xue Xue Bao | pmid:3452960 |
| Kalla NR et al. | Involvement of prostaglandin in the antifertility effects of gossypol. | 1986 | Contraception | pmid:3465506 |
| Dhaliwal MK et al. | Cytogenetic analysis of a gossypol-induced murine myxosarcoma. | 1987 | J. Natl. Cancer Inst. | pmid:3473256 |
| Förstermann U et al. | Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3487639 |
| Alheid U et al. | Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. | 1987 | Thromb. Res. | pmid:3499684 |
| Baccetti B et al. | Action of gossypol on rat germinal cells. II. The acrosome. | 1987 | Gamete Res | pmid:3506897 |
| Henderson J et al. | Occupation-related male infertility: a review. | 1986 | Clin Reprod Fertil | pmid:3527400 |
| de Peyster A et al. | Membrane structural/functional perturbations induced by gossypol. Effects on membrane order, liposome permeability, and insulin-sensitive hexose transport. | 1986 | Biochem. Pharmacol. | pmid:3533079 |
| Suzuki H et al. | [Studies on naturally occurring toxic substances (III). Determination of gossypol in seed kernels of cotton plants by high performance liquid chromatography]. | 1986 | Eisei Shikenjo Hokoku | pmid:3567428 |
| Giridharan N et al. | Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats. | 1987 | Contraception | pmid:3568662 |
| Wu YW et al. | [Electrophysiological and ultrastructural studies of the blood-epididymis barrier of the rat]. | 1986 | Shi Yan Sheng Wu Xue Bao | pmid:3577546 |
| Hadley MA and Burgos MH | Gossypol injected in the rat epididymal fat pad inhibits epididymal sperm motility. | 1986 | Microsc Electron Biol Celular | pmid:3587061 |
| Kim I et al. | Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. | 1987 | Contraception | pmid:3608484 |
| Srivastava AK and Padmanaban G | Gossypol mediated DNA degradation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619941 |
| Sinha Hikim AP and Hoffer AP | Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol. | 1987 | Contraception | pmid:3621939 |
| Zakhidov ST et al. | [Cytogenetic study of the effect of gossypol on mouse germ cells]. | 1987 | Genetika | pmid:3623090 |
| Wang MZ | Analysis of gossypol by high performance liquid chromatography. | 1987 | J Ethnopharmacol | pmid:3626590 |
| Huang L et al. | Resolution of racemic gossypol. | 1987 | J Ethnopharmacol | pmid:3626591 |
| Wang NG et al. | Effect of (-)- and (+)-gossypol on fertility in male rats. | 1987 | J Ethnopharmacol | pmid:3626592 |
| Yao KQ et al. | Effect of (+/-)-, (+)- and (-)-gossypol on the lactate dehydrogenase-X activity of rat testis. | 1987 | J Ethnopharmacol | pmid:3626593 |
| Chen QQ et al. | Comparative study on the metabolism of optical gossypol in rats. | 1987 | J Ethnopharmacol | pmid:3626594 |
| pmid:3631888 | ||||
| Lindberg MC et al. | Comparative anti-fertility effects of gossypol enantiomers in male hamsters. | 1987 | Int. J. Androl. | pmid:3654015 |
| Glander HJ | [Comments on reversible nonhormonal contraception in the male]. | 1987 | Hautarzt | pmid:3654202 |
| Yang YQ and Wu XY | Antifertility mechanisms of gossypol acetic acid in female rats. | 1987 | J. Reprod. Fertil. | pmid:3656277 |
| Buttar HS and Nayak BN | Cytogenetic effects of vaginally administered gossypol in murine bone marrow cells. | 1987 | Toxicol. Lett. | pmid:3660427 |
| Hoffer AP et al. | Ultrastructural, fertility, and spermicidal studies with isomers and derivatives of gossypol in male hamsters. | 1987 | Biol. Reprod. | pmid:3689857 |
| Ye YX et al. | Cardiodepressant actions of the orally active male contraceptive, gossypol, in guinea-pig heart muscle. | 1987 | Eur. J. Pharmacol. | pmid:3691653 |
| Rosenberg LJ et al. | Inhibition of DNA polymerase alpha by gossypol. | 1986 | Biochim. Biophys. Acta | pmid:3697356 |
| Eisele GR | A perspective on gossypol ingestion in swine. | 1986 | Vet Hum Toxicol | pmid:3705437 |
| Schmidt JH and Wells R | Recovery of soluble proteins from glanded cotton tissues with amines. | 1986 | Anal. Biochem. | pmid:3706729 |
| Wu DF et al. | Pharmacokinetics of (+/-)-, (+)-, and (-)-gossypol in humans and dogs. | 1986 | Clin. Pharmacol. Ther. | pmid:3709025 |
| Pelletier RM and Friend DS | Sertoli cell junctional complexes in gossypol-treated neonatal and adult guinea pigs. | 1986 May-Jun | J. Androl. | pmid:3721997 |
| Wong YK and Li JH | [Quantum pharmacological investigations of gossypol and some simple aromatic compounds]. | 1986 | Yao Xue Xue Bao | pmid:3728037 |
| Medrano FJ and Andreu JM | Binding of gossypol to purified tubulin and inhibition of its assembly into microtubules. | 1986 | Eur. J. Biochem. | pmid:3732269 |
| Walia V et al. | Effect of gossypol on peripheral blood cells. | 1986 | Indian J. Med. Res. | pmid:3733198 |
| Morris ID et al. | Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers. | 1986 | J. Reprod. Fertil. | pmid:3735252 |
| Sheriff DS et al. | Gossypol and lipid peroxidation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3740171 |
| Ahluwalia B et al. | Morphologic and endocrine changes in the reproductive organs in rats implanted with gossypol acetate pellet in the testis. | 1986 Jul-Aug | J. Androl. | pmid:3745012 |
| Heywood R et al. | The toxicity of gossypol to the male rat. | 1986 | Toxicology | pmid:3750328 |
| Burgos C et al. | In vitro inhibition by gossypol of oxidoreductases from human tissues. | 1986 | Biochem. Pharmacol. | pmid:3754138 |
| Joseph AE et al. | Cytotoxicity of enantiomers of gossypol. | 1986 | Br. J. Cancer | pmid:3756086 |
| Wichmann K et al. | Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism. | 1986 | Contraception | pmid:3757514 |
| Tam SC | Acute hypokalemic effect of gossypol. | 1986 | Can. J. Physiol. Pharmacol. | pmid:3768796 |
| Whaley KJ et al. | Monkey lactate dehydrogenase-C4 as a model for the interaction of enzymes with gossypol. | 1986 | Contraception | pmid:3769483 |
| Hu F et al. | Gossypol effects on cultured normal and malignant melanocytes. | 1986 | In Vitro Cell. Dev. Biol. | pmid:3771439 |
| Reyes J et al. | Membrane actions of male contraceptive gossypol tautomers. | 1986 | Biochim. Biophys. Acta | pmid:3778905 |
| Chongthammakun S et al. | Effects of gossypol on human and monkey sperm motility in vitro. | 1986 | Contraception | pmid:3791997 |
| Stephens DT et al. | Kinetic characterization of the inhibition of purified cynomolgus monkey lactate dehydrogenase isozymes by gossypol. | 1986 Nov-Dec | J. Androl. | pmid:3793617 |
| Sein GM | The embryotoxic and immunodepressive effects of gossypol. | 1986 | Am. J. Chin. Med. | pmid:3799526 |
| Benz C et al. | Lactic dehydrogenase isozymes, 31P magnetic resonance spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123. | 1987 | J. Clin. Invest. | pmid:3805280 |
| Jiang DH et al. | [The comparison of some properties of gossypol recrystallized from different solvents]. | 1986 | Yao Xue Xue Bao | pmid:3811948 |
| pmid:3832713 | ||||
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| Vongsorasak L and Svasti J | Inhibition of liquefaction and protein degradation in human semen by gossypol. | 1985 | Int. J. Androl. | pmid:3835162 |
| Sadykov AS et al. | [Effect of gossypol on spermatogenesis and fertility in man and mammals]. | 1985 Jul-Aug | Ontogenez | pmid:3900844 |
| McClarty GA et al. | Ribonucleotide reductase: an intracellular target for the male antifertility agent, gossypol. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3907637 |
| Qian SZ | Gossypol-hypokalaemia interrelationships. | 1985 | Int. J. Androl. | pmid:3908325 |
| Wang C and Yeung RT | Gossypol and hypokalaemia. | 1985 | Contraception | pmid:3910352 |
| Hamasaki Y and Tai HH | Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases. | 1985 | Biochim. Biophys. Acta | pmid:3919771 |
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| Zhang LS | [Effect of gossypol on serum gonadotropin and testosterone levels: long-term follow-up study]. | 1985 | Zhonghua Yi Xue Za Zhi | pmid:3931874 |
| Zhang GY et al. | Dynamic study of serum gonadotrophin and testosterone levels in gossypol-treated men. Long term follow-up study of 60 cases. | 1985 | Int. J. Androl. | pmid:3932223 |
| Hawkins GE et al. | Physiological effects of whole cottonseed in the diet of lactating dairy cows. | 1985 | J. Dairy Sci. | pmid:3934243 |
| Gossypol--a new antifertility agent for males. | 1979 | Gynecol. Obstet. Invest. | pmid:393575 | |
| Wang WC et al. | [Changes of serum concentrations of testosterone, LH and FSH in men taking gossypol]. | 1985 | Yao Xue Xue Bao | pmid:3938917 |
| Chen Y et al. | The effect of gossypol on the frequency of DNA-strand breaks in human leukocytes in vitro. | 1986 | Mutat. Res. | pmid:3951461 |
| Wang JM et al. | Electrolyte composition of rete testis fluid and cauda epididymal plasma and spermatozoa from rats following gossypol treatment. | 1986 Jan-Feb | Andrologia | pmid:3954086 |
| Rikihisa Y and Lin YC | Taenia taeniaeformis: inhibition of metacestode development in the rat by gossypol. | 1986 | Exp. Parasitol. | pmid:3956677 |
| Liang JC and Ye WS | Clastogenicity of a male contraceptive, gossypol, in mammalian cell cultures with and without the metabolic activation by S9 mix. | 1985 | Environ. Res. | pmid:3967635 |
| Shi QX and Friend DS | Effect of gossypol acetate on guinea pig epididymal spermatozoa in vivo and their susceptibility to capacitation in vitro. | 1985 Jan-Feb | J. Androl. | pmid:3972719 |
| Vainio P et al. | Hydrolysis of phospholipid monolayers by human spermatozoa. Inhibition by male contraceptive gossypol. | 1985 | Biochim. Biophys. Acta | pmid:3978108 |
| Matlin SA et al. | (-)-Gossypol: an active male antifertility agent. | 1985 | Contraception | pmid:3987276 |
| Sufi SB et al. | Inhibition by (+) and (-) isomers of gossypol of testosterone release from mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987277 |
| Donaldson A et al. | Inhibition by gossypol of testosterone production by mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987278 |
| Colman N et al. | Non-mutagenicity of gossypol in the Salmonella/mammalian-microsome plate assay. | 1979 | Environ Mutagen | pmid:399915 |
| Rao PN et al. | Antitumor effects of gossypol on murine tumors. | 1985 | Cancer Chemother. Pharmacol. | pmid:4006045 |
| Lin YC et al. | Gossypol in female fertility control: ovum implantation and early pregnancy inhibited in rats. | 1985 | Life Sci. | pmid:4010468 |
| Wu YW et al. | Effect of gossypol on the potential difference of rat seminiferous tubules. | 1985 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:4012264 |
| Tone JN and Jensen DR | Radioiron utilization and gossypol acetic acid in male rats. | 1985 | Drug Chem Toxicol | pmid:4017900 |
| Maliwal BP et al. | Spectroscopic study of the interaction of gossypol with bovine serum albumin. | 1985 | Int. J. Pept. Protein Res. | pmid:4019021 |
| Haspel HC et al. | Effect of gossypol on erythrocyte membrane function: specific inhibition of inorganic anion exchange and interaction with band 3. | 1985 | J. Pharmacol. Exp. Ther. | pmid:4032282 |
| Beaudoin AR | The embryotoxicity of gossypol. | 1985 | Teratology | pmid:4049283 |
| Gao H et al. | [Primary observations on distal renal tubule acidosis in 177 cases caused by gossypol intoxication]. | 1985 | Zhonghua Nei Ke Za Zhi | pmid:4053804 |
| Fody EP and Walker EM | Effects of drugs on the male and female reproductive systems. | 1985 Nov-Dec | Ann. Clin. Lab. Sci. | pmid:4062226 |
| Kim SH et al. | Gossypol, a hyperthermic sensitizer of HeLa cells. | 1985 | Cancer Res. | pmid:4063984 |
| Wang MZ et al. | High-performance liquid chromatography with electrochemical detection of gossypol in human plasma. | 1985 | J. Chromatogr. | pmid:4066879 |
| Rikihisa Y et al. | Histopathologic changes of uterus following gossypol treatment during early pregnancy in rats. | 1985 | Anat. Rec. | pmid:4073564 |
| Kim IC et al. | Inhibition of LDH-X by gossypol optical isomers. | 1985 Nov-Dec | J. Androl. | pmid:4077725 |
| Wang WH et al. | [Influence of salicylaldehyde and its analogs on the antispermatogenic effect of gossypol]. | 1985 | Yao Xue Xue Bao | pmid:4083027 |