| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myxosarcoma | D009236 | 1 associated lipids |
| Darier Disease | D007644 | 2 associated lipids |
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Genital Neoplasms, Male | D005834 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Protein Deficiency | D011488 | 5 associated lipids |
| Infertility, Female | D007247 | 5 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li K et al. | Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. | 2015 | Biomaterials | pmid:25477180 |
| Quinn BA et al. | Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. | 2015 | Cancer Res. | pmid:26032425 |
| Bhatia C et al. | Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. | 2015 | Chem. Biol. Interact. | pmid:25526675 |
| Câmara AC et al. | Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. | 2015 | PLoS ONE | pmid:26600470 |
| Gong Y et al. | Valproic Acid Enhances the Anti-tumor Effect of (-)-gossypol to Burkitt Lymphoma Namalwa Cells. | 2015 | Biomed. Environ. Sci. | pmid:26582100 |
| Maji S et al. | Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. | 2015 | Oncotarget | pmid:26009874 |
| Lan L et al. | Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. | 2015 | Mol Oncol | pmid:25933687 |
| Sarkar S et al. | Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic. | 2015 | Oncotarget | pmid:25926554 |
| Mani J et al. | Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). | 2015 | BMC Cancer | pmid:25885284 |
| Zeng QF et al. | The response of meat ducks from 15 to 35 d of age to gossypol from cottonseed meal. | 2015 | Poult. Sci. | pmid:25834247 |
| Hanus J et al. | Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway. | 2015 | Mol. Cell. Biol. | pmid:25802279 |
| Zhan W et al. | Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. | 2015 | Mol Med Rep | pmid:25672487 |
| Zhang H et al. | Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs). | 2015 | Biomaterials | pmid:25468367 |
| Sorokina EV et al. | [Features of dynamics of sera cytokines in patients with erythema multiforme during immunotherapy]. | 2014 Jan-Feb | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:24738292 |
| Cho H et al. | Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance. | 2014 | PLoS ONE | pmid:24587157 |
| Sonpavde G et al. | Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer. | 2014 | BJU Int. | pmid:24298897 |
| Jang GH and Lee M | BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). | 2014 | Life Sci. | pmid:24625733 |
| Li G et al. | RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. | 2014 | Cell Death Dis | pmid:24434521 |
| Mei H et al. | Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer. | 2014 | Neoplasma | pmid:24299314 |
| Spijkers-Hagelstein JA et al. | Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101. | 2014 | Eur. J. Cancer | pmid:24703900 |