| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myxosarcoma | D009236 | 1 associated lipids |
| Darier Disease | D007644 | 2 associated lipids |
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Genital Neoplasms, Male | D005834 | 3 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
| Protein Deficiency | D011488 | 5 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yeow WS et al. | Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. | 2006 | J. Thorac. Cardiovasc. Surg. | pmid:17140955 |
| Dale GL and Friese P | Bax activators potentiate coated-platelet formation. | 2006 | J. Thromb. Haemost. | pmid:16970802 |
| Uzal FA et al. | Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding. | 2005 | J. Vet. Diagn. Invest. | pmid:16475530 |
| Deng S et al. | Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. | 2013 | J. Vet. Sci. | pmid:23820203 |
| Gossypol prospects. | 1984 | Lancet | pmid:6144835 | |
| Soufir JC et al. | Epididymal effects of gossypol. | 1984 | Lancet | pmid:6145995 |
| Pösö H et al. | Gossypol, a powerful inhibitor of human spermatozoal metabolism. | 1980 | Lancet | pmid:6103251 |
| Susman E | Cottonseed-oil byproduct as anticancer radiation sensitiser. | 2004 | Lancet Oncol. | pmid:15536689 |
| Mellon JE et al. | Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus. | 2011 | Lett. Appl. Microbiol. | pmid:21291481 |
| Mellon JE et al. | Growth inhibitory effects of gossypol and related compounds on fungal cotton root pathogens. | 2014 | Lett. Appl. Microbiol. | pmid:24713043 |
| Meng Y et al. | (-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. | 2007 | Leuk. Lymphoma | pmid:17926190 |
| Balakrishnan K et al. | Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. | 2013 | Leuk. Lymphoma | pmid:22866921 |
| Ni Z et al. | Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma. | 2013 | Leuk. Lymphoma | pmid:23398207 |
| Anderson MA et al. | BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia. | 2013 | Leuk. Lymphoma | pmid:23339446 |
| Soderquist R et al. | Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. | 2013 | Leukemia | pmid:23640104 |
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| Lin YC et al. | Transfer of 3H-gossypol to neonatal rats via milk of nursing dams. | 1992 | Life Sci. | pmid:1435075 |
| Gilbert NE et al. | Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. | 1995 | Life Sci. | pmid:7596222 |
| Wang X et al. | Cytotoxic effect of gossypol on colon carcinoma cells. | 2000 | Life Sci. | pmid:11105982 |
| Gu Y et al. | Inhibitory effect of gossypol on human chorionic gonadotropin (hCG)-induced progesterone secretion in cultured bovine luteal cells. | 1990 | Life Sci. | pmid:2168511 |
| Benz CC et al. | Gossypol effects on endothelial cells and tumor blood flow. | 1991 | Life Sci. | pmid:1875793 |
| Zhang M et al. | Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways. | 2007 | Life Sci. | pmid:17156797 |
| Lin YC et al. | Binding of 3H-gossypol in organelles of cultured bovine luteal cells. | 1992 | Life Sci. | pmid:1734162 |
| Ye YX et al. | Modification of the positive inotropic effects of catecholamines, cardiac glycosides and Ca2+ by the orally active male contraceptive, gossypol, in isolated guinea-pig heart. | 1989 | Life Sci. | pmid:2557505 |
| Lin YC et al. | Inhibition of in vitro fertilization and early embryonic development in hamsters by gossypol. | 1994 | Life Sci. | pmid:8090055 |
| Hu YF et al. | Gossypol inhibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells. | 1993 | Life Sci. | pmid:8255144 |
| Lin YC et al. | Gossypol in female fertility control: ovum implantation and early pregnancy inhibited in rats. | 1985 | Life Sci. | pmid:4010468 |
| Jang GH and Lee M | BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). | 2014 | Life Sci. | pmid:24625733 |
| Posinovec J | [Gossypol - the newest agent for the prevention of male fertility]. | 1983 | Lijec Vjesn | pmid:6888153 |
| Abou-Donia MB et al. | Metabolic fate of gossypol: the metabolism of 14C-gossypol in rats. | 1970 | Lipids | pmid:5484207 |
| Shandilya LN and Clarkson TB | Hypolipidemic effects of gossypol in cynomolgus monkeys (Macaca fascicularis). | 1982 | Lipids | pmid:6952061 |
| Przybylski P et al. | CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state. | 2008 | Magn Reson Chem | pmid:18338327 |
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| Harper MJ | Fertility control. | 1982 Oct-Dec | Med Res Rev | pmid:6757597 |
| Semon B | Dietary intake of cottonseed toxins is hypothesized to be a partial cause of Alzheimer's disorder. | 2012 | Med. Hypotheses | pmid:22136946 |
| Cheng CC | A common structural pattern among many biologically active compounds of natural and synthetic origin. | 1986 | Med. Hypotheses | pmid:3090407 |
| Yurekli B et al. | Can gossypol be a hope for transsexual patients (male to female) before sex reassignment surgery? Just for adjusting the body to mind. | 2009 | Med. Hypotheses | pmid:19647947 |
| Blackstaffe L et al. | Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. | 1997 | Melanoma Res. | pmid:9429219 |
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| Costantino A et al. | Current status and future perspectives in male contraception. | 2007 | Minerva Ginecol | pmid:17576406 |
| Wang J et al. | Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. | 2013 | Mol Biosyst | pmid:23532321 |
| Baoleri X et al. | Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. | 2015 | Mol Med Rep | pmid:26238307 |
| Zhan W et al. | Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. | 2015 | Mol Med Rep | pmid:25672487 |
| Zhang X et al. | Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo. | 2014 | Mol Med Rep | pmid:25060748 |
| Lan L et al. | Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. | 2015 | Mol Oncol | pmid:25933687 |
| Bork S et al. | Identification of Babesia bovis L-lactate dehydrogenase as a potential chemotherapeutical target against bovine babesiosis. | 2004 | Mol. Biochem. Parasitol. | pmid:15478796 |
| Conners R et al. | Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. | 2005 | Mol. Biochem. Parasitol. | pmid:15978953 |
| Dando C et al. | The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum. | 2001 | Mol. Biochem. Parasitol. | pmid:11704270 |