Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yuan JR | [Methods of extraction and purification of gossypol]. | 1984 | Shengzhi Yu Biyun | pmid:12339570 |
Alarcón B et al. | Screening for new compounds with antiherpes activity. | 1984 | Antiviral Res. | pmid:6517562 |
Wang NG et al. | [Effects of (-) and (+) gossypol on the fertility of male rats]. | 1984 | Yao Xue Xue Bao | pmid:6544566 |
Admasu A and Chandravanshi BS | Spectrophotometric determination of total gossypol in cottonseeds and cottonseed meals. | 1984 | Anal. Chem. | pmid:6546479 |
Jiang Y and Zhou TH | [Polarographic study on gossypol]. | 1984 | Yao Xue Xue Bao | pmid:6496091 |
Zhou LF and Lei HP | [Effect of gossypol acetic acid on the uterus and ovary]. | 1984 | Yao Xue Xue Bao | pmid:6496095 |
Tso WW | Gossypol inhibits Ehrlich ascites tumor cell proliferation. | 1984 | Cancer Lett. | pmid:6498805 |
Ma XN and Back DJ | Inhibition of hepatic microsomal enzymes by gossypol in the rat. | 1984 | Contraception | pmid:6478834 |
GÃ¥fvels M et al. | Toxic effects of the antifertility agent gossypol in male rats. | 1984 | Toxicology | pmid:6485000 |
Rovan E et al. | Effect of gossypol on bull spermatozoa in vitro. | 1984 | Urol. Res. | pmid:6485187 |
Wang NG et al. | [Antisteroidal and antigonadotrophic effects of gossypol acetic acid in rats]. | 1984 | Yao Xue Xue Bao | pmid:6464763 |
Zu PD et al. | Electron microscopic observations of the effects of gossypol on the human endometrium. | 1984 | Am. J. Obstet. Gynecol. | pmid:6465231 |
Hunt S and Mittwoch U | Effects of gossypol on sperm counts in two inbred strains of mice. | 1984 | J. Reprod. Fertil. | pmid:6694149 |
Floridi A et al. | The effect of gossypol and Lonidamine on electron transport in Ehrlich ascites tumor mitochondria. | 1984 | Exp. Mol. Pathol. | pmid:6705894 |
Wang Y and Rao PN | Effect of gossypol on DNA synthesis and cell cycle progression of mammalian cells in vitro. | 1984 | Cancer Res. | pmid:6690046 |
Penningroth SM | Pharmacological basis of therapeutics: gossypol, an oral male contraceptive? | 1984 | J Med Soc N J | pmid:6592366 |
Tvermyr SM et al. | Glucose metabolism in rat germ cells: mechanism of action of gossypol. | 1984 | Ann. N. Y. Acad. Sci. | pmid:6598341 |
Tuszynski GP and Cossu G | Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines. | 1984 | Cancer Res. | pmid:6581864 |
Herrera J et al. | Modifications in the testis steroidogenic pathways in rats fed with cottonseed flour. | 1984 | Arch. Androl. | pmid:6236762 |
Wang RL et al. | [Effect of gossypol acetic acid on the induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6240903 |
Han ML et al. | [A comparative study on rapid and slow loading of gossypol in the treatment of gynecological diseases]. | 1984 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6241066 |
Wang RL et al. | [Effect of gossypol acetic acid on induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6242220 |
Ali SF and El-Sewedy SM | Effect of gossypol on liver metabolic enzymes in male rats. | 1984 | Toxicol. Lett. | pmid:6084346 |
Steiner M et al. | In vivo study of LDH isoenzyme activities in heart, liver and testis cytosols of gossypol-treated rats. | 1984 | Int. J. Androl. | pmid:6526516 |
Breitbart H et al. | Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. | 1984 | Int. J. Androl. | pmid:6151940 |
Marcelle GB et al. | Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography. | 1984 | J Pharm Sci | pmid:6716251 |
Nordenskjöld M and Lambert B | Gossypol induces DNA strand breaks in human fibroblasts and sister chromatid exchanges in human lymphocytes in vitro. | 1984 | J. Med. Genet. | pmid:6716412 |
Tang F and Wong PY | Serum potassium and aldosterone levels in gossypol-treated rats. | 1984 | Int. J. Androl. | pmid:6724725 |
Sattayasai N et al. | High-performance liquid chromatographic determination of gossypol in plasma. | 1984 | J. Chromatogr. | pmid:6725489 |
Wang JM et al. | Effect of gossypol on testicular blood flow and testosterone production in rats. | 1984 | J. Reprod. Fertil. | pmid:6726673 |
Demoulin A | [Male contraception]. | 1984 | Rev Med Liege | pmid:6729295 |
Kalla NR et al. | Effect of gossypol on testicular testosterone production in vitro. | 1983 Sep-Oct | J. Androl. | pmid:6630052 |
Zhuang LZ et al. | Effects of gossypol on rat Sertoli and Leydig cells in primary culture and established cell lines. | 1983 Sep-Oct | J. Androl. | pmid:6685120 |
Weinbauer GF et al. | Toxicity of gossypol at antifertility dosages in male rats: statistical analysis of lethal rates and body weight responses. | 1983 May-Jun | Andrologia | pmid:6881556 |
Waller DP et al. | Effect of (+)-gossypol on fertility in male hamsters. | 1983 Jul-Aug | J. Androl. | pmid:6618998 |
Gombe S | A review of the current status in male contraceptive studies. | 1983 | East Afr Med J | pmid:6354690 |
Blanco A et al. | Effect of gossypol upon motility and ultrastructure of Trypanosoma cruzi. | 1983 | J. Protozool. | pmid:6363678 |
Aitken RJ | New techniques in contraception: gossypol, vaccines and GnRH analogues. | 1983 | Proc Annu Symp Eugen Soc | pmid:6366784 |
Prasad MR and Diczfalusy E | New contraceptives for men. What are the prospects? | 1983 | Int. J. Androl. | pmid:6413430 |
Kennedy WP et al. | Gossypol inhibition of acrosin and proacrosin, and oocyte penetration by human spermatozoa. | 1983 | Biol. Reprod. | pmid:6416323 |
Weinbauer GF et al. | The endocrine status of gossypol - treated male rats. | 1983 | Andrologia | pmid:6421193 |
Huang TH | [The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells]. | 1983 | Zhonghua Yi Xue Za Zhi | pmid:6407739 |
Ma XN et al. | [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. | 1983 | Yao Xue Xue Bao | pmid:6433647 |
Olgiati KL and Toscano WA | Kinetics of gossypol inhibition of bovine lactate dehydrogenase X. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6615526 |
Huang GZ et al. | [Etiological study of the burning sensation disease]. | 1983 | Acta Acad Med Wuhan | pmid:6621973 |
Xue SP et al. | Subcellular site of antispermatogenic effect of gossypol and its possible molecular mechanism of action. | 1983 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:6623054 |
Ratsula K et al. | Vaginal contraception with gossypol: a clinical study. | 1983 | Contraception | pmid:6684533 |
Hong SK et al. | Effects of gossypol on PAH transport in the rabbit kidney slice. | 1983 | Toxicol. Appl. Pharmacol. | pmid:6140776 |
Ye WS et al. | Toxicity of a male contraceptive, gossypol, in mammalian cell cultures. | 1983 | In Vitro | pmid:6185412 |
Posinovec J | [Gossypol - the newest agent for the prevention of male fertility]. | 1983 | Lijec Vjesn | pmid:6888153 |