Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Meng Y et al. | Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. | 2008 | Mol. Cancer Ther. | pmid:18645028 |
Politzer WM | Long-term clinical remission of a patient with chronic lymphocytic leukemia using alternative treatment option: cottonseed oil (gossypol). | 2008 | Phytomedicine | pmid:18573644 |
Shaaban WF et al. | Reproductive toxicologic effects of gossypol on male rabbits: biochemical, enzymatic, and electrolytic properties of seminal plasma. | 2008 | Fertil. Steril. | pmid:17953964 |
Jia L et al. | Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. | 2008 | Cancer Chemother. Pharmacol. | pmid:17356822 |
Brozic P et al. | Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. | 2008 | Curr. Med. Chem. | pmid:18220769 |
Przybylski P et al. | EI MS and ESI MS studies of the bisesquiterpene from cotton seeds: Gossypol and its Aza-derivatives. | 2008 | J Mass Spectrom | pmid:18200654 |
Kitada S et al. | Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). | 2008 | Blood | pmid:18202226 |
Tang G et al. | Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins. | 2008 | J. Med. Chem. | pmid:18237106 |
Kline MP et al. | R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. | 2008 | Exp. Hematol. | pmid:18346839 |
Gao F et al. | Interactive effects of elevated CO2 and cotton cultivar on tri-trophic interaction of Gossypium hirsutum, Aphis gossyppii, and Propylaea japonica. | 2008 | Environ. Entomol. | pmid:18348793 |
Moon DO et al. | Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells. | 2008 | Cancer Lett. | pmid:18314260 |
Sprogøe K et al. | Combining HPLC-PDA-MS-SPE-NMR with circular dichroism for complete natural product characterization in crude extracts: levorotatory gossypol in Thespesia danis. | 2008 | J. Nat. Prod. | pmid:18290629 |
Paoluzzi L et al. | Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. | 2008 | Blood | pmid:18292288 |
Przybylski P et al. | CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state. | 2008 | Magn Reson Chem | pmid:18338327 |
Sikora MJ et al. | Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. | 2008 | Cancer Biol. Ther. | pmid:18376141 |
Dowd MK and Pelitire SM | HPLC preparation of the chiral forms of 6-methoxy-gossypol and 6,6'-dimethoxy-gossypol. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18407810 |
Ojha P et al. | Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. | 2008 | Anim. Reprod. Sci. | pmid:17207942 |
Balakrishnan K et al. | Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. | 2008 | Blood | pmid:18566329 |
Wang X et al. | Bioactivities of gossypol, 6-methoxygossypol, and 6,6'-dimethoxygossypol. | 2008 | J. Agric. Food Chem. | pmid:18517219 |
Johnson PW | New targets for lymphoma treatment. | 2008 | Ann. Oncol. | pmid:18519406 |
Marzo I and Naval J | Bcl-2 family members as molecular targets in cancer therapy. | 2008 | Biochem. Pharmacol. | pmid:18638457 |
Liu J et al. | Stereoselective coupling of hemigossypol to form (+)-gossypol in moco cotton is mediated by a dirigent protein. | 2008 | Phytochemistry | pmid:18639908 |
Villaseñor M et al. | Gossypol disrupts embryo development in heifers. | 2008 | J. Dairy Sci. | pmid:18650278 |
Aoyama K | [Determination of gossypol in feeds by HPLC]. | 2008 | Shokuhin Eiseigaku Zasshi | pmid:18787315 |
Sun Y et al. | Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. | 2008 | Cancer Biol. Ther. | pmid:18769131 |
Moon DO et al. | Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. | 2008 | FEBS Lett. | pmid:18775705 |
Przybylski P et al. | Molecular structures and stability constants of gossypol and its aza-derivative complexes with silver(I) cations studied by potentiometric, ESI MS, NMR, and AM1d semiempirical methods. | 2008 | J Phys Chem A | pmid:18698745 |
Boonsri S et al. | Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. | 2008 | J. Nat. Prod. | pmid:18553924 |
Zhou DR et al. | Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of Connexin43. | 2008 | Toxicol In Vitro | pmid:18706992 |
Tang Y et al. | [Progress in small-molecule inhibitors of Bcl-2 family proteins]. | 2008 | Yao Xue Xue Bao | pmid:18819468 |
Janssen CO et al. | Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18845435 |
Mi JX et al. | Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. | 2008 | Acta Pharmacol. Sin. | pmid:19026166 |
Stipanovic RD et al. | Effect of racemic, (+)- and (-)-gossypol on survival and development of Heliothis virescens larvae. | 2008 | Environ. Entomol. | pmid:19036185 |
Karaca B et al. | Profiling of angiogenic cytokines produced by hormone- and drug-refractory prostate cancer cell lines, PC-3 and DU-145 before and after treatment with gossypol. | 2008 | Eur. Cytokine Netw. | pmid:19103523 |
Macoska JA et al. | -(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro. | 2008 Nov-Dec | Pharmacol. Res. | pmid:18840529 |
Sheweita SA et al. | N-Nitrosodimethylamine changes the expression of glutathione S-transferase in the liver of male mice: The role of antioxidants. | 2008 Nov-Dec | J. Biochem. Mol. Toxicol. | pmid:19111000 |
Zhai G et al. | A liposomal delivery vehicle for the anticancer agent gossypol. | 2008 Sep-Oct | Anticancer Res. | pmid:19035313 |
Przybylski P et al. | Complexes of heterocyclic aza-derivatives of phytoalexin from cotton plant-gossypol with alkali metal cations and perchlorate anion studied by ESI mass spectrometric method in the positive and negative modes. | 2009 | J Mass Spectrom | pmid:19189269 |
Przybylski P et al. | Antifungal activity of alkyl and heterocyclic aza-derivatives of gossypol as well as their complexes with NaClO4 against Fusarium oxysporum f. sp. lupini. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19264482 |
Balakrishnan K et al. | AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. | 2009 | Blood | pmid:18836097 |
Anilkumar KJ et al. | Synergistic interactions between Cry1Ac and natural cotton defenses limit survival of Cry1Ac-resistant Helicoverpa zea (Lepidoptera: Noctuidae) on Bt cotton. | 2009 | J. Chem. Ecol. | pmid:19588197 |
Huang YW et al. | (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. | 2009 | Anticancer Res. | pmid:19528479 |
Yurekli B et al. | Can gossypol be a hope for transsexual patients (male to female) before sex reassignment surgery? Just for adjusting the body to mind. | 2009 | Med. Hypotheses | pmid:19647947 |
El-Sharaky AS et al. | Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. | 2009 | Food Chem. Toxicol. | pmid:19665044 |
Hu GX et al. | The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes. | 2009 | J. Steroid Biochem. Mol. Biol. | pmid:19429456 |
Barba-Barajas M et al. | Gossypol induced apoptosis of polymorphonuclear leukocytes and monocytes: involvement of mitochondrial pathway and reactive oxygen species. | 2009 | Immunopharmacol Immunotoxicol | pmid:19235535 |
Wang WQ et al. | [Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20030926 |
Xu P et al. | Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. | 2009 | Anticancer Res. | pmid:20032412 |
Cheng W et al. | [Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line]. | 2009 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:19968063 |
Pérez A et al. | Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19386788 |