Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
El'chits SV et al. | [Glucoamylase immobilization on silochrome using gossypol]. | 1981 Jan-Feb | Ukr. Biokhim. Zh. | pmid:6259793 |
Wang RL et al. | [Effect of gossypol acetic acid on induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6242220 |
Han ML et al. | [A comparative study on rapid and slow loading of gossypol in the treatment of gynecological diseases]. | 1984 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6241066 |
Wang RL et al. | [Effect of gossypol acetic acid on the induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6240903 |
Herrera J et al. | Modifications in the testis steroidogenic pathways in rats fed with cottonseed flour. | 1984 | Arch. Androl. | pmid:6236762 |
Madzhidov UV | [T-suppressors in experimental adjuvant arthritis and immunosuppression]. | 1984 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:6230839 |
Wang MZ | [High performance liquid chromatographic analysis of gossypol]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228325 |
Cao J and Liu GZ | [Reversibility of azoospermia following gossypol withdrawal]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228316 |
Chen XM et al. | [Effects of gossypol on lactate dehydrogenase isoenzyme-X in human spermatozoa]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228315 |
Fei RR et al. | [Effects of gossypol on rat testicular mitochondria]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228314 |
Qian SZ et al. | Antispermatogenic activity of gossypol in rats on low-potassium diet. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6228118 |
Xu Y et al. | [Antagonism of antifertility effect of gossypol by aspirin]. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6225300 |
Gu ZP et al. | Morphological changes in the testes and epididymides of rats after gossypol. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6223497 |
Han ML | [Clinical observation of the gossypol treatment of endometriosis and uterine myoma and the location of the pharmacological action]. | 1982 | Zhong Xi Yi Jie He Za Zhi | pmid:6219819 |
Tso WW et al. | Effect of gossypol on boar spermatozoal adenosine triphosphate metabolism. | 1982 | Arch. Androl. | pmid:6219642 |
Tong SM et al. | Human antifertility effect of gossypol cytologic observation of semen. | 1982 | Chin. Med. J. | pmid:6216077 |
Sun YB et al. | [Effect of gossypol on potassium excretion of male rats]. | 1982 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6216008 |
Wang WH | [Antagonistic effect of Smilax sp. on gossypol toxicity (author's transl)]. | 1982 | Zhong Yao Tong Bao | pmid:6212150 |
Baker ME | Gossypol inhibits estrogen binding to rat alpha-fetoprotein. | 1984 | FEBS Lett. | pmid:6207049 |
Ye WS et al. | Toxicity of a male contraceptive, gossypol, in mammalian cell cultures. | 1983 | In Vitro | pmid:6185412 |
Labzo SS et al. | [Stimulation of interferon formation by natural and synthetic inducers in cultures of human tonsil cells]. | 1980 Jan-Feb | Vopr. Virusol. | pmid:6158181 |
Breitbart H et al. | Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. | 1984 | Int. J. Androl. | pmid:6151940 |
Soufir JC et al. | Epididymal effects of gossypol. | 1984 | Lancet | pmid:6145995 |
Gossypol prospects. | 1984 | Lancet | pmid:6144835 | |
Hong SK et al. | Effects of gossypol on PAH transport in the rabbit kidney slice. | 1983 | Toxicol. Appl. Pharmacol. | pmid:6140776 |
Chang CC et al. | Studies on gossypol. I. Toxicity, antifertility, and endocrine analyses in male rats. | 1982 | Int. J. Fertil. | pmid:6131039 |
Ke YB and Tso WW | Variations of gossypol susceptibility in rat spermatozoa during spermatogenesis. | 1982 | Int. J. Fertil. | pmid:6122656 |
Pösö H et al. | Gossypol, a powerful inhibitor of human spermatozoal metabolism. | 1980 | Lancet | pmid:6103251 |
Olgiati KL et al. | Gossypol modulation of nucleotide metabolizing enzymes in the reproductive tract of male rats. | 1984 | Biol. Reprod. | pmid:6095938 |
Bi XF et al. | [Effects of potassium on the inhibitory effect of gossypol on Na,K-ATPase in vitro]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6087611 |
SaÄitkulov AM et al. | [Biological characteristics of new interferon inducers created on a gossypol base]. | 1984 Nov-Dec | Vopr. Virusol. | pmid:6084903 |
Ali SF and El-Sewedy SM | Effect of gossypol on liver metabolic enzymes in male rats. | 1984 | Toxicol. Lett. | pmid:6084346 |
Roehm JN et al. | Accumulation and elimination of dietary gossypol in the organs of rainbow trout. | 1967 | J. Nutr. | pmid:6054742 |
Braham JE et al. | Effect of gossypol on the iron-binding capacity of serum in swine. | 1967 | J. Nutr. | pmid:6052995 |
Margalith P | Inhibitory effect of gossypol on microorganisms. | 1967 | Appl Microbiol | pmid:6049314 |
Smith FH | Determination of gossypol in leaves and flower buds of Gossypium. | 1967 | J Am Oil Chem Soc | pmid:6041387 |
Braham JE et al. | Effect of calcium and gossypol on the performance of swine and on certain enzymes and other blood constituents. | 1967 | J. Nutr. | pmid:6018252 |
Clawson AJ and Smith FH | Effect of dietary iron on gossypol toxicity and on residues of gossypil in porcine liver. | 1966 | J. Nutr. | pmid:5950205 |
Muzaffaruddin M and Saxena ER | Physicochemical studies on the composition and stability of metal-gossypol complexes. I. Fe+++ gossypol complex. | 1966 | J Am Oil Chem Soc | pmid:5939582 |
Sharma MP et al. | Effects of levels of protein and gossypol, and length of feeding period on the accumulation of gossypol in tissues of swine. | 1966 | J. Nutr. | pmid:5931188 |
Danke RJ and Tillman AD | Effect of free gossypol and supplemental dietary iron on blood constituents of rats. | 1965 | J. Nutr. | pmid:5897732 |
Smith FH and Clawson AJ | Effect of diet on accumulation of gossypol in the organs of swine. | 1965 | J. Nutr. | pmid:5892976 |
Wang YE et al. | [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:583588 |
de Buckle TS et al. | Two food applications of cottonseed flours and meals. | 1979 | J Am Oil Chem Soc | pmid:583421 |
Graham GG et al. | Dietary protein quality in infants and children. II. Metabolic studies with cottonseed flour. | 1969 | Am. J. Clin. Nutr. | pmid:5819114 |
Cherry JP et al. | Potential for improving cottonseed quality by genetic and agronomic practices. | 1978 | Adv. Exp. Med. Biol. | pmid:581532 |
Alford BB and Onley K | The minimum cottonseed protein required for nitrogen balance in women. | 1978 | J. Nutr. | pmid:580097 |
Cornu A et al. | [Utilization of gossypol-free cottonseed and its by-products as human food]. | 1977 | Ann Nutr Aliment | pmid:579293 |
Baugher WL and Campbell TC | Gossypol detoxication by fungi. | 1969 | Science | pmid:5786644 |
Lyman CM et al. | Metabolism of gossypol in the chick. | 1969 | J Am Oil Chem Soc | pmid:5779540 |
Jones LA and Smith FH | Effect of gossypol on the removal of nitrogen and amino acids from feed in digestion by the rat. | 1977 | J. Anim. Sci. | pmid:576597 |
Jones LA and Smith FH | Effect of bound gossypol and amino acid supplementation of glandless cottonseed meal on the growth of weanling rats. | 1977 | J. Anim. Sci. | pmid:576596 |
Albrecht JE et al. | Effects of high gossypol cottonseed meal on the electrocardiogram of swine. | 1968 | J. Anim. Sci. | pmid:5744268 |
Albrecht JE et al. | Effect of initial weight and days on feed on the accumulation of gossypol in pig livers. | 1971 | J. Anim. Sci. | pmid:5546881 |
Buitrago JA et al. | Effects of dietary iron on gossypol accumulation in and elimination from porcine liver. | 1970 | J. Anim. Sci. | pmid:5520345 |
Vichkanova SA et al. | [Antiviral properties of gossypol in experimental influenza pneumonia]. | 1970 | Antibiotiki | pmid:5501368 |
Smith FH and Clawson AJ | The effects of dietary gossypol on animals. | 1970 | J Am Oil Chem Soc | pmid:5487114 |
Abou-Donia MB et al. | Metabolic fate of gossypol: the metabolism of 14C-gossypol in rats. | 1970 | Lipids | pmid:5484207 |
Tone JN and Jensen DR | Effect of ingested gossypol on the growth performance of rats. | 1970 | Experientia | pmid:5478639 |
Mauron J | [Chemical behavior of proteins at the time of preparation of nutrients and their biological effects]. | 1970 | Int Z Vitaminforsch | pmid:5451301 |
Fry KE | Some factors affecting the Hill reaction activity in cotton chloroplasts. | 1970 | Plant Physiol. | pmid:5427116 |
Goriunova LV and Vichkanova SA | [Study of antiviral effect of gossypol on chick embryo model]. | 1969 Sep-Oct | Farmakol Toksikol | pmid:5364687 |
Wood AB et al. | Conformation and hydrogen bonding of gossypol. | 1969 | Chem. Ind. | pmid:5357782 |
Nadakavukaren MJ et al. | Effect of gossypol on the ultrastructure of rat spermatozoa. | 1979 | Cell Tissue Res. | pmid:535032 |
Chen ZC et al. | [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532653 |
Klaasen GH | [Gossypol, properties and occurrence]. | 1965 | Pharm Weekbl | pmid:5321432 |
Krylov VF | [Treatment of patients with influenza]. | 1975 | Ter. Arkh. | pmid:52894 |
Rolz C et al. | [Method of wet concentration of protein of cotton seed cake processed by screw press]. | 1971 | Arch Latinoam Nutr | pmid:5172841 |
Braham JE et al. | [Gossypol absorption in rats and in pigs]. | 1971 | Arch Latinoam Nutr | pmid:5172839 |
Dunbar CE and Herman RL | Visceral granuloma in brook trout (Salvelinus fontinalis). | 1971 | J. Nutr. | pmid:5171403 |
Husby FM and Kroening GH | Energy value of cottonseed meal for swine. | 1971 | J. Anim. Sci. | pmid:5171308 |
Berg LR and Lawrence WW | Cottonseed meal, dehydrated grass and ascorbic acid as dietary factors preventing toxicity of vanadium for the chick. | 1971 | Poult. Sci. | pmid:5109894 |
Albrecht JE et al. | Rate of depletion and route of elimination of intravenously injected gossypol in swine. | 1972 | J. Anim. Sci. | pmid:5085300 |
Smith FH | Effect of gossypol bound to cottonseed protein on growth of weanling rats. | 1972 Jul-Aug | J. Agric. Food Chem. | pmid:5068584 |
Qian SZ et al. | [The potassium-depleting effect of gossypol on isolated rabbit heart and it's possible mechanism (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:506710 |
Abou-Donia MB and Dieckert JW | Gossypol: subcellular localization and stimulation of rat liver microsomal oxidases. | 1971 | Toxicol. Appl. Pharmacol. | pmid:4998823 |
Vichkanova SA and Goriunova LV | [Study of virulicidal effect of gossypol in vitro]. | 1968 | Antibiotiki | pmid:4974209 |
Fedeli E and Jacini G | Lipid composition of vegetable oils. | 1971 | Adv. Lipid Res. | pmid:4942102 |
Tanksley TD et al. | Inhibition of pepsinogen activation by gossypol. | 1970 | J. Biol. Chem. | pmid:4922043 |
Abou-Donia MB and Dieckert JW | Urinary and biliary excretion of 14C-gossypol in swine. | 1974 | J. Nutr. | pmid:4830281 |
Kilburn KH et al. | Two patterns for bronchial damage from inhaled materials. | 1974 | Chest | pmid:4819236 |
Skutches CL et al. | Effect of dietary free gossypol on blood components and tissue iron in swine and rats. | 1974 | J. Nutr. | pmid:4816926 |
Tone JN and Jensen DR | Hematological effects of injected gossypol and iron in rats. | 1974 Jan-Feb | J. Agric. Food Chem. | pmid:4811630 |
Ogot JO | The performance of pigs in Kenya fed cottonseed meal in mixtures of concentrate supplements. | 1973 | Bull Epizoot Dis Afr | pmid:4808120 |
Mayorga H et al. | [Extraction and precipitation of cottonseed protein by the wet method]. | 1973 | Arch Latinoam Nutr | pmid:4801265 |
Lee J | The inheritance of gossypol level in Gossypium. II. Inheritance of seed gosypol in two trains of cultivated Gossypoium barbadense L. | 1973 | Genetics | pmid:4769299 |
Finlay TH et al. | Mechanism of the gossypol inactivation of pepsinogen. | 1973 | J. Biol. Chem. | pmid:4718749 |
Herman DL and Smith FH | Effect of bound gossypol on the absorption of iron by rats. | 1973 | J. Nutr. | pmid:4705274 |
Skutches CL et al. | Effect of intravenous gossypol injection on iron ultilization in swine. | 1973 | J. Nutr. | pmid:4705271 |
Kornegay ET et al. | Fungal-treated cottonseed meal for swine. | 1972 | J. Nutr. | pmid:4678034 |
Wong RC et al. | Studies on the nature of the inhibition by gossypol of the transformation of pepsinogen to pepsin. | 1972 | J. Biol. Chem. | pmid:4551945 |
de Peyster A and Wang YY | Gossypol--proposed contraceptive for men passes the Ames test. | 1979 | N. Engl. J. Med. | pmid:450009 |
Skutches CL and Smith FH | Metabolism of gossypol, biosynthesized from methyl-14C-and carboxyl-14 C-labeled sodium acetate, in rat. | 1974 | J Am Oil Chem Soc | pmid:4479245 |
Abou-Donia MB et al. | Gossypol: antagonistic effect on toxicity of insecticides to Spodoptera littoralis. | 1974 | Experientia | pmid:4435119 |
Skutches CL and Smith FH | Effect of phenobarbital on the level of gossypol in the liver and the effect of gossypol and phenobarbital on liver microsomal O-demethylation and lipid peroxidation activities in the rat. | 1974 | J. Nutr. | pmid:4430931 |
Smith FH | Preparation of 14C-gossypol by incorporation of acetate-1-14C and acetate-2-14C by biosynthesis. | 1974 | J Am Oil Chem Soc | pmid:4415176 |
el-Nockrashy AS et al. | Biochemical changes in cottonseed during germination. | 1974 | Nahrung | pmid:4365683 |
Meksongsee LA et al. | The in vivo effect of gossypol on cytochrome oxidase, succinoxidase, and succinic dehydrogenase in animal tissues. | 1970 Sep-Oct | J. Agric. Food Chem. | pmid:4319770 |
Heinstein PF et al. | Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates. | 1970 | J. Biol. Chem. | pmid:4318479 |
Cottonseed meal and tumors. | 1969 | Nutr. Rev. | pmid:4311090 |