Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Colin-Negrete J et al. | Effect of whole cottonseed on serum constituents, fragility of erythrocyte cells, and reproduction of growing Holstein heifers. | 1996 | J. Dairy Sci. | pmid:8961108 |
Barhoumi R et al. | Alteration of oxytocin-induced calcium oscillations in clone 9 cells by toxin exposure. | 1996 | Fundam Appl Toxicol | pmid:8921340 |
Shidaifat F et al. | Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. | 1996 | Cancer Lett. | pmid:8913264 |
Hervé JC et al. | Contraceptive gossypol blocks cell-to-cell communication in human and rat cells. | 1996 | Eur. J. Pharmacol. | pmid:8911921 |
Achudume AC and Eno TL | Characterization of ion interference in gossypol consumption. | 1996 | Adv Contracept | pmid:8910664 |
Akingbemi BT et al. | Ethanol intake may modify gossypol toxicosis in the rat. | 1996 Sep-Oct | J Appl Toxicol | pmid:8889787 |
Zavos PM and Zarmakoupis-Zavos PN | The inhibitory effects of gossypol on human sperm motility characteristics: possible modes of reversibility of those effects. | 1996 | Tohoku J. Exp. Med. | pmid:8888505 |
Hansen LL and Jaroszewski JW | Effect of gossypol on cultured TM3 Leydig and TM4 Sertoli cells: 31P and 23Na NMR study. | 1996 | NMR Biomed | pmid:8887371 |
Akingbemi BT et al. | Gossypol toxicosis in the rat associated with protein malnutrition and experimental infection with Trypanosoma brucei. | 1996 | J. Comp. Pathol. | pmid:8878748 |
Akingbemi BT et al. | Infection with Trypanosoma brucei potentiates the antifertility effect of gossypol, especially in the protein-malnourished male rat. | 1996 | Int. J. Androl. | pmid:8876268 |
Mushtaq M et al. | Gossypol inhibits human chorionic gonadotropin-stimulated testosterone production by cultured canine testicular interstitial cells. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8829766 |
Chang WY et al. | Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8827831 |
Graier WF et al. | High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions. | 1996 | Diabetes | pmid:8826976 |
Cusack PM and Perry V | The effect of feeding whole cottonseed on the fertility of bulls. | 1995 | Aust. Vet. J. | pmid:8825312 |
Barhoumi R and Burghardt RC | Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro. | 1996 | Fundam Appl Toxicol | pmid:8812278 |
Wu Y et al. | Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy. | 1996 | Biophys. J. | pmid:8804592 |
Szücs G et al. | Characterization of volume-activated chloride currents in endothelial cells from bovine pulmonary artery. | 1996 | J. Membr. Biol. | pmid:8801351 |
Guan MZ and Wang NG | [Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats]. | 1996 | Yao Xue Xue Bao | pmid:8762457 |
Teng CS | Gossypol-induced apoptotic DNA fragmentation correlates with inhibited protein kinase C activity in spermatocytes. | 1995 | Contraception | pmid:8749604 |
González-Garza MT et al. | Orally administered gossypol has no effect on eight hamster erythrocytic enzymes. | 1995 | Contraception | pmid:8749602 |
Gschwentner M et al. | Blockade of swelling-induced chloride channels by phenol derivatives. | 1996 | Br. J. Pharmacol. | pmid:8733574 |
Liang XS et al. | Developing gossypol derivatives with enhanced antitumor activity. | 1995 | Invest New Drugs | pmid:8729944 |
Fan LP et al. | [Emergency treatment and care of hypokalemia paralysis due to gossypol poisoning]. | 1995 | Zhonghua Hu Li Za Zhi | pmid:8716068 |
Ohmura H | [Suppressive effect of Gossypol, Gossypolone and serum from Gossypol treated rats on steroidogenesis in cultured porcine granulosa cells]. | 1996 | Nippon Ika Daigaku Zasshi | pmid:8707919 |
Javed MH and Waqar MA | Protective effect of histidine by inhibition of gossypol on rat's liver LDH-5. | 1995 | Biochem. Soc. Trans. | pmid:8654811 |
Kim HL et al. | Accumulation of gossypol enantiomers in ovine tissues. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8653593 |
Nwoha PU and Aire TA | Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine. | 1995 | Contraception | pmid:8605786 |
Nwoha PU and Aire TA | The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats. | 1995 | Contraception | pmid:8605785 |
Nwoha PU | The blood constituents of gossypol-treated, protein-malnourished Wistar rats. | 1995 | Contraception | pmid:8605784 |
Zelski RZ et al. | Gossypol toxicity in preruminant calves. | 1995 | Aust. Vet. J. | pmid:8599575 |
Teng CS et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. VI. Alteration in nuclear factors for interaction with histone gene promoter. | 1995 | Contraception | pmid:8536450 |
Orhan G et al. | The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index. | 1993 | Contraception | pmid:8508667 |
Hasegawa K et al. | Angiotensin II-induced endothelium-dependent relaxation of fowl aorta. | 1993 | Am. J. Physiol. | pmid:8498599 |
Chang CJ et al. | Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8480076 |
Flack MR et al. | Oral gossypol in the treatment of metastatic adrenal cancer. | 1993 | J. Clin. Endocrinol. Metab. | pmid:8473376 |
Aletor VA | Allelochemicals in plant foods and feedingstuffs: 1. Nutritional, biochemical and physiopathological aspects in animal production. | 1993 | Vet Hum Toxicol | pmid:8434459 |
Price WD et al. | Naturally occurring toxins in feedstuffs: Center for Veterinary Medicine Perspective. | 1993 | J. Anim. Sci. | pmid:8407668 |
Cuéllar A and RamÃrez J | Further studies on the mechanism of action of gossypol on mitochondrial membrane. | 1993 | Int. J. Biochem. | pmid:8405656 |
Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. IV. The activity for the modification of core histones. | 1993 | Contraception | pmid:8403913 |
Srivastava S et al. | Maturation, capacitation, and metabolism of goat spermatozoa using magnetic resonance methods. | 1993 Jul-Aug | Andrologia | pmid:8394662 |
Miranda FJ et al. | Endothelial modulation of 5-hydroxytryptamine-induced contraction in goat cerebral arteries. | 1993 | Gen. Pharmacol. | pmid:8365646 |
Lin TS et al. | Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol. | 1993 | Biochem. Pharmacol. | pmid:8347147 |
Lei HQ and Xu YX | [Effects of gossypol acetic acid on the motility of rat oviduct smooth muscle]. | 1993 | Yao Xue Xue Bao | pmid:8328273 |
Kulp SK et al. | In vitro uptake and autoradiographic localization of tritiated gossypol in Taenia taeniaeformis metacestodes. | 1993 | Parasitol. Res. | pmid:8327450 |
Xiao DM et al. | [Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A]. | 1993 | Yao Xue Xue Bao | pmid:8285048 |
Wu D and Reidenberg MM | Effect of potassium deficiency and gossypol on urinary N-acetyl-beta-glucosaminidase excretion in the rat. | 1993 | Contraception | pmid:8275698 |
González-Garza MT et al. | Entamoeba histolytica: inhibition of malic enzyme and alcohol dehydrogenase by (+/- )-, (+)-, and (-)- gossypol. | 1993 | Arch. Med. Res. | pmid:8274846 |
Ye W et al. | Effect of intra-vas deferens injection of gossypol-polylactic acid on fertility and spermatogenesis in rats. | 1993 | Chin. Med. Sci. J. | pmid:8274715 |
Moh PP et al. | Effect of gossypol on 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase activities in adult rat testes. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8272571 |
Sullivan JL et al. | Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. | 1993 | J. Dairy Sci. | pmid:8270698 |