Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Weinbauer GF et al. | The endocrine status of gossypol - treated male rats. | 1983 | Andrologia | pmid:6421193 |
Kalla NR et al. | Studies on the male antifertility agent gossypol acetic acid. VII. Effect of motility stimulated factors on the revival of human spermatozoal motility after gossypol treatment in vitro. | 1986 Jul-Aug | Andrologia | pmid:3019180 |
Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. V. Effect of gossypol acetic acid on the fertility of male rats. | 1982 Nov-Dec | Andrologia | pmid:7165122 |
Wang JM et al. | Electrolyte composition of rete testis fluid and cauda epididymal plasma and spermatozoa from rats following gossypol treatment. | 1986 Jan-Feb | Andrologia | pmid:3954086 |
Ikeda M | Inhibition kinetics of NAD-linked enzymes by gossypol acetic acid. | 1990 Sep-Oct | Andrologia | pmid:2073051 |
Kalla NR et al. | Studies on the male antifertility agent gossypol acetic acid. VI. Effect of gossypol acetic acid on the fertility of bonnet monkey. Macaca radiata. | 1984 May-Jun | Andrologia | pmid:6465549 |
Weinbauer GF et al. | Toxicity of gossypol at antifertility dosages in male rats: statistical analysis of lethal rates and body weight responses. | 1983 May-Jun | Andrologia | pmid:6881556 |
Akingbemi BT et al. | Chronic ethanol intake may delay the onset of gossypol-induced infertility in the male rat. | 1997 Jul-Aug | Andrologia | pmid:9263570 |
Srivastava S et al. | Maturation, capacitation, and metabolism of goat spermatozoa using magnetic resonance methods. | 1993 Jul-Aug | Andrologia | pmid:8394662 |
Levinsky H et al. | Inhibition of sialyl transferase activity by gossypol acetic acid in human seminal plasma. | 1991 Mar-Apr | Andrologia | pmid:1952122 |
Nakamura M et al. | Metabolism of round spermatids in the rat: effect of gossypol on the glucose transport. | 1988 Sep-Oct | Andrologia | pmid:3207199 |
Price CP et al. | Dissecting the behavior of a promiscuous solvate former. | 2006 | Angew. Chem. Int. Ed. Engl. | pmid:16493716 |
Ojha P et al. | Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. | 2008 | Anim. Reprod. Sci. | pmid:17207942 |
Cornu A et al. | [Utilization of gossypol-free cottonseed and its by-products as human food]. | 1977 | Ann Nutr Aliment | pmid:579293 |
Kunesch N et al. | [Preparation of derivatives of the aldehydic functions of gossypol]. | 1990 | Ann Pharm Fr | pmid:2082795 |
Fody EP and Walker EM | Effects of drugs on the male and female reproductive systems. | 1985 Nov-Dec | Ann. Clin. Lab. Sci. | pmid:4062226 |
Tvermyr SM et al. | Glucose metabolism in rat germ cells: mechanism of action of gossypol. | 1984 | Ann. N. Y. Acad. Sci. | pmid:6598341 |
Chadha S et al. | Alterations and reversibility of the effects of gossypol acetic acid on the intestinal uptake of end product nutrients in normal and protein calorie-malnourished male rats. | 1991 | Ann. Nutr. Metab. | pmid:1905512 |
Sonpavde G et al. | Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. | 2012 | Ann. Oncol. | pmid:22112969 |
Johnson PW | New targets for lymphoma treatment. | 2008 | Ann. Oncol. | pmid:18519406 |
Qian SZ and Wang ZG | Gossypol: a potential antifertility agent for males. | 1984 | Annu. Rev. Pharmacol. Toxicol. | pmid:6375548 |
SaÄitkulov AM et al. | [Relation between interferon-inducing activity of natural interferon inducers and their chemical structure]. | 1991 | Antibiot. Khimioter. | pmid:1719947 |
Amanov N et al. | [Intestinal microbial ecology and its modulation under the influence of immunodepressants]. | 1989 | Antibiot. Khimioter. | pmid:2802878 |
Khadzhibaev GS et al. | [Interferonogenic activity of gossypol, a low-molecular substance]. | 1978 | Antibiotiki | pmid:206198 |
Vichkanova SA et al. | [Antiviral properties of gossypol in experimental influenza pneumonia]. | 1970 | Antibiotiki | pmid:5501368 |
Vichkanova SA and Goriunova LV | [Study of virulicidal effect of gossypol in vitro]. | 1968 | Antibiotiki | pmid:4974209 |
Hedvat M et al. | Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. | 2012 | Anticancer Agents Med Chem | pmid:22931411 |
Shelley MD et al. | Structure-activity studies on gossypol in tumor cell lines. | 2000 | Anticancer Drugs | pmid:10831280 |
Sun J et al. | ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. | 2008 | Anticancer Drugs | pmid:18827561 |
Schteingart DE et al. | Expression of anti-apoptosis genes determines the response of adrenal cancer to apoptosis-inducing chemotherapy. | 2010 | Anticancer Res. | pmid:21187456 |
Ye W et al. | Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. | 2007 Jan-Feb | Anticancer Res. | pmid:17352222 |
Jiang J et al. | The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. | 2004 Jan-Feb | Anticancer Res. | pmid:15015581 |
Brandes AA et al. | New drugs in recurrent high grade gliomas. | 2000 May-Jun | Anticancer Res. | pmid:10928126 |
Huang YW et al. | Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. | 2006 Sep-Oct | Anticancer Res. | pmid:17094491 |
Huang YW et al. | Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. | 2006 May-Jun | Anticancer Res. | pmid:16827126 |
Thomas M et al. | Effects of gossypol on the cell cycle phases in T-47D human breast cancer cells. | 1991 Jul-Aug | Anticancer Res. | pmid:1746904 |
Zhong S et al. | Aromatase expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and suppressed by (-)-gossypol. | 2010 | Anticancer Res. | pmid:21187493 |
Shidaifat F et al. | Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle. | 1997 Mar-Apr | Anticancer Res. | pmid:9137441 |
Zhai G et al. | A liposomal delivery vehicle for the anticancer agent gossypol. | 2008 Sep-Oct | Anticancer Res. | pmid:19035313 |
Huang YW et al. | (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. | 2009 | Anticancer Res. | pmid:19528479 |
Reddish JM et al. | (-)-Gossypol containing hen sera and a myosin (-)-gossypol conjugate reduces the proliferation of MCF-7 cells. | 2010 | Anticancer Res. | pmid:20332451 |
Xu P et al. | Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. | 2009 | Anticancer Res. | pmid:20032412 |
Zhong S et al. | (-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. | 2013 | Anticancer Res. | pmid:23482766 |
Jiang J et al. | The effects of gossypol on the invasiveness of MAT-LyLu cells and MAT-LyLu cells from the metastasized lungs of MAT-LyLu-bearing Copenhagen rats. | 2000 Nov-Dec | Anticancer Res. | pmid:11205308 |
Jiang J et al. | Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells. | 2002 May-Jun | Anticancer Res. | pmid:12168828 |
Liu S et al. | The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. | 2002 Jan-Feb | Anticancer Res. | pmid:12017312 |
Lin TS et al. | Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol. | 1989 | Antimicrob. Agents Chemother. | pmid:2619282 |
Alarcón B et al. | Screening for new compounds with antiherpes activity. | 1984 | Antiviral Res. | pmid:6517562 |
An T et al. | Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1. | 2012 | Antiviral Res. | pmid:22426469 |
Margalith P | Inhibitory effect of gossypol on microorganisms. | 1967 | Appl Microbiol | pmid:6049314 |