Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Han ZY | [Relationship between eating cotton-seed oil and blood potassium levels]. | 1988 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:3219964 |
Sun TS | [Long-term follow-up studies on patients poisoned by cottonseed oil]. | 1986 | Zhonghua Yi Xue Za Zhi | pmid:3091216 |
Liu GZ | [Clinical trial of gossypol as a male contraceptive: a randomized controlled study]. | 1985 | Zhonghua Yi Xue Za Zhi | pmid:3921206 |
Zhang LS | [Effect of gossypol on serum gonadotropin and testosterone levels: long-term follow-up study]. | 1985 | Zhonghua Yi Xue Za Zhi | pmid:3931874 |
Hei LS | [Electron-microscopic observations on bioptic testicular tissue of cancerous patients after oral administration of gossypol (author's transl)]. | 1981 | Zhonghua Yi Xue Za Zhi | pmid:6804060 |
Huang TH | [The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells]. | 1983 | Zhonghua Yi Xue Za Zhi | pmid:6407739 |
Gao H et al. | [Primary observations on distal renal tubule acidosis in 177 cases caused by gossypol intoxication]. | 1985 | Zhonghua Nei Ke Za Zhi | pmid:4053804 |
Zhou DR et al. | [Gossypol decreases the expression of connexin 43 in Sertoli cells]. | 2011 | Zhonghua Nan Ke Xue | pmid:22141269 |
Zha SW et al. | [Male antifertility drugs and cell apoptosis]. | 2008 | Zhonghua Nan Ke Xue | pmid:18297819 |
Fan LP et al. | [Emergency treatment and care of hypokalemia paralysis due to gossypol poisoning]. | 1995 | Zhonghua Hu Li Za Zhi | pmid:8716068 |
Zhou SW | [Clinical experience with a gossypol-releasing IUD]. | 1988 | Zhonghua Fu Chan Ke Za Zhi | pmid:3058417 |
Zhang YW et al. | [Estrogen and progesterone cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy]. | 1994 | Zhonghua Fu Chan Ke Za Zhi | pmid:8082445 |
Liu YX | [The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327032 |
[A preliminary study on gossypol used in gynecology and its mechanism of action (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327033 | |
Zhou SW | [Clinical use of gossypol in gynecology (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327034 |
Zhu PD | [Electron microscopic observations on the effect of gossypol on the human endometrium]. | 1984 | Zhonghua Fu Chan Ke Za Zhi | pmid:6536444 |
YU TW | [Ultrastructural study of the testis in 22 persons based on the effect of gossypol]. | 1987 | Zhonghua Bing Li Xue Za Zhi | pmid:2957085 |
Zhang SC et al. | [The adverse effects of the preparations of the active principles of Chinese herbal drugs]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8267848 |
Cui GH et al. | [Determination of gossypol in cotton root bark by HPLC]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12774395 |
Huang HF and Wang M | [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells]. | 1994 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8000225 |
Lu Q | [Comparative studies on antifertility mechanism and toxicology of Tripterygium wilfordii monomer T4 and gossypol]. | 1990 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2151263 |
Ye WS et al. | [Clastogenicity of a male contraceptive, gossypol, in mammalian cell cultures with and without metabolic activation by S9 mix]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2944636 |
Ye YX et al. | [Studies on the action mechanism of gossypol with fixed concentration radioactive-ligand receptor assay]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2944651 |
Xu Y et al. | [Analysis of the effect of gossypol on the activity of purified LDH-X]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2952308 |
Ding LA et al. | [Hepatoma initiating and promoting effects of gossypol]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2986867 |
Zhang JB et al. | [Comparison of the action of racemic (+/-) and optically active (-and+) gossypols on HeLa cells]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2938762 |
Chen QQ | [Relationship between gossypol concentration and testicular damage]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2968182 |
Cheng JX | [Effect of gossypol (+/-, +, -) on Leydig cells of the rat in vitro]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970318 |
Tang MY | [Electron microscopic observation of the effect of gossypol on atypical hyperplasia of the endometrium]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970320 |
Ye WS | [Clastogenicity of gossypol as a male contraceptive in sperm head anomalies in mice]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970321 |
Wang YF | [Observation on blood biochemical indices after gossypol treatment in gynecological cases]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2972411 |
Zhou LF | [Effect of racemic, (+),(-) gossypol on rat testis, epididymis, liver and kidney]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2978403 |
Li FY et al. | [The antiandrogen effect of gossypol and its influence on androgen receptor]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:3158419 |
Han ML et al. | [A comparative study on rapid and slow loading of gossypol in the treatment of gynecological diseases]. | 1984 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6241066 |
Sun YB et al. | [Effect of gossypol on potassium excretion of male rats]. | 1982 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6216008 |
Fei RR et al. | [Effects of gossypol on rat testicular mitochondria]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228314 |
Chen XM et al. | [Effects of gossypol on lactate dehydrogenase isoenzyme-X in human spermatozoa]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228315 |
Cao J and Liu GZ | [Reversibility of azoospermia following gossypol withdrawal]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228316 |
Wang MZ | [High performance liquid chromatographic analysis of gossypol]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228325 |
Li H and He X | [The effects of optical isomers of gossypol on Sertoli cells in vitro]. | 1993 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:8242829 |
Liang DC et al. | [Studies on distribution of 14C-gossypol in subcellular fractions of rat testes and site of gossypol action (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459173 |
Bi XF et al. | [Preliminary study on gossypol in causing hypokalemia (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459178 |
Han HL | [Gossypol treatment for menopausal functional bleeding, myoma of uterus and endometriosis--preliminary report (author's transl)]. | 1980 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6451316 |
Wu T et al. | [Effects of gossypol acetic acid on human ejaculated sperm Ca2+ influx and rat vas deferens contraction action]. | 1996 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:9388965 |
Wu F et al. | [Comparative study on the effect of gossypol and T7 on human spermatozoa ATPase activity]. | 1998 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:11367690 |
Xue S | [A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903461 |
Wang L et al. | [Combined use of steroid hormone and low dose gossypol for antifertility and its mechanism in rats]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903462 |
Cao J et al. | [Effect of low dose gossypol treatment on male sperm nuclear basic protein]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903463 |
Cheng W et al. | [Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line]. | 2009 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:19968063 |
Li XX et al. | [Spermicidal effects in vitro of gossypol acetic acid-povidone coprecipitate]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2954422 |
Zhuang LZ et al. | Comparison of sensitivities of rat spermatozoa, Sertoli and Leydig cells to gossypol acetic acid in vitro by the LD50. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2955650 |
Dou SJ and Fu YF | [Effects of gossypol acetic acid on heart mitochondrial membranes ATPase]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:2975138 |
Wang WH et al. | [Antifertility actions of gossypol derivatives and analogues]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2088004 |
Zhao DP et al. | [Effect of gossypol formic acid on the fluidity of the spermatocyte plasma membrane of the rat]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2945391 |
Ye YX et al. | [Mode of inhibitory action of gossypol on Na+, K+-ATPase in vitro]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:3035869 |
Berry CN et al. | Gossypol is a potent inhibitor of the NAD+-dependent dehydrogenase responsible for the inactivation of prostaglandins. | 1985 | Zhongguo Yao Li Xue Bao | pmid:3158161 |
Wang RL et al. | [Effect of gossypol acetic acid on the induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6240903 |
Wang RL et al. | [Effect of gossypol acetic acid on induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6242220 |
Gu ZP et al. | Morphological changes in the testes and epididymides of rats after gossypol. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6223497 |
Xu Y et al. | [Antagonism of antifertility effect of gossypol by aspirin]. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6225300 |
Qian SZ et al. | Antispermatogenic activity of gossypol in rats on low-potassium diet. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6228118 |
Bi XF et al. | [Effects of potassium on the inhibitory effect of gossypol on Na,K-ATPase in vitro]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6087611 |
Shu HD et al. | [Effects of gossypol acetate on neuromuscular transmission (author's transl)]. | 1982 | Zhongguo Yao Li Xue Bao | pmid:6283787 |
Pathak HK et al. | Gossypol, ouabain and vanadate on the isolated perfused rat kidney and Na, K-ATPase. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6326465 |
Sang GW et al. | [Chronic toxicity of gossypol and the relationship to its metabolic fate in dogs and monkeys (author's transl)]. | 1980 | Zhongguo Yao Li Xue Bao | pmid:6461173 |
Shi QX et al. | [Analysis on exfoliated cells in human semen after oral administrations of gossypol acetic acid (author's transl)]. | 1981 | Zhongguo Yao Li Xue Bao | pmid:6462027 |
Wang MS et al. | NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase isoforms in guinea pig kidney with gossypol inhibition. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10322899 |
Lin J et al. | [Effect of apogossypolone on induction apoptosis in multiple myeloma cells and its mechanisms]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:19236755 |
Wang WQ et al. | [Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20030926 |
Cheng W et al. | [Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541072 |
Lv G et al. | [The effect of gossypol, praziquantel and artemether on recombinant lactate dehydrogenase from Schistosoma japonicum]. | 2007 | Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi | pmid:18441994 |
Wang WH | [Antagonistic effect of Smilax sp. on gossypol toxicity (author's transl)]. | 1982 | Zhong Yao Tong Bao | pmid:6212150 |
Huang HF and Wang M | [Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro]. | 1990 | Zhong Xi Yi Jie He Za Zhi | pmid:2208435 |
Wang YF | [Late effect of gossypol treatment in gynecological diseases--a clinical study of 72 cases]. | 1985 | Zhong Xi Yi Jie He Za Zhi | pmid:3158438 |
Ye XQ | [Clinical and experimental study of gossypol in the treatment of dysfunctional menorrhagia, endometriosis and fibromyoma of the uterus]. | 1988 | Zhong Xi Yi Jie He Za Zhi | pmid:3191544 |
Han ML | [Clinical observation of the gossypol treatment of endometriosis and uterine myoma and the location of the pharmacological action]. | 1982 | Zhong Xi Yi Jie He Za Zhi | pmid:6219819 |
Madzhidov UV | [T-suppressors in experimental adjuvant arthritis and immunosuppression]. | 1984 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:6230839 |
Sorokina EV et al. | [Influence of immunovac-VP-4 therapy on innate immunity effectors in patients with darier erythema annulare centrifugum]. | 2013 Nov-Dec | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:24605681 |
Sorokina EV et al. | [Features of dynamics of sera cytokines in patients with erythema multiforme during immunotherapy]. | 2014 Jan-Feb | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:24738292 |
Glander HJ | [Gossypol and other nonhormonal substances for the inhibition of male fertility]. | 1988 | Zentralbl Gynakol | pmid:3213305 |
Swan MA et al. | Electron microscopic observations on the effect of gossypol on rat cauda epididymis. | 1990 | Z Mikrosk Anat Forsch | pmid:2220026 |
Zheng YH et al. | [Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells]. | 1991 | Yao Xue Xue Bao | pmid:1668561 |
Han SD et al. | [Study on quality of gossypol recrystalized from chloroform]. | 1989 | Yao Xue Xue Bao | pmid:2609986 |
Deng HL et al. | [The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats]. | 1989 | Yao Xue Xue Bao | pmid:2618689 |
Yuan XB et al. | [Study on polymorphism of gossypol by infrared spectrophotometry and X-ray diffraction]. | 1991 | Yao Xue Xue Bao | pmid:1950572 |
Wong YK and Li JH | [Quantum pharmacological investigations of gossypol and some simple aromatic compounds]. | 1986 | Yao Xue Xue Bao | pmid:3728037 |
Wang WC et al. | [Changes of serum concentrations of testosterone, LH and FSH in men taking gossypol]. | 1985 | Yao Xue Xue Bao | pmid:3938917 |
Wang YE et al. | [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:583588 |
Chen ZC et al. | [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532653 |
Guan MZ and Wang NG | [Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats]. | 1996 | Yao Xue Xue Bao | pmid:8762457 |
Tang XC et al. | [Comparative studies on the absorption, distribution and excretion of 14C-gossypol in four species of animals (author's transl)]. | 1980 | Yao Xue Xue Bao | pmid:6779501 |
Jiang DH and Xue H | [Monoanilinogossypol--the impurity possibly present in gossypol (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7102321 |
Jiang Y and Zhou TH | [Polarographic study on gossypol]. | 1984 | Yao Xue Xue Bao | pmid:6496091 |
Zhou LF and Lei HP | [Effect of gossypol acetic acid on the uterus and ovary]. | 1984 | Yao Xue Xue Bao | pmid:6496095 |
Wong SM et al. | 14C-gossypol: optimum conditions for synthesis by cotton seedlings. | 1983 | Yao Xue Xue Bao | pmid:6687973 |
Lei HP | [Prospect of gossypol as a contraceptive agents for men]. | 1983 | Yao Xue Xue Bao | pmid:6637482 |
Xiao DM et al. | [Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A]. | 1993 | Yao Xue Xue Bao | pmid:8285048 |
Lei HQ and Xu YX | [Effects of gossypol acetic acid on the motility of rat oviduct smooth muscle]. | 1993 | Yao Xue Xue Bao | pmid:8328273 |
Chen Y et al. | [Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice]. | 1997 | Yao Xue Xue Bao | pmid:11596197 |
Yang B et al. | [The effects of gossypol on rat luteal cells, human decidual cells and cytotrophoblasts]. | 1997 | Yao Xue Xue Bao | pmid:11596304 |