MeSH term | MeSH ID | Detail |
---|---|---|
Enterobacteriaceae Infections | D004756 | 5 associated lipids |
Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
Paclitaxel is a lipid of Prenol Lipids (PR) class. Paclitaxel is associated with abnormalities such as Multiple Sulfatase Deficiency Disease, Peripheral Neuropathy, Pulmonary Embolism, Painful Bladder Syndrome and athymia. The involved functions are known as synergism, Metabolic Inhibition, Drug Efflux, Disease regression and Oxidation. Paclitaxel often locates in Back, Hepatic, Microtubules, Head and Cytoskeleton. The associated genes with Paclitaxel are CDAN1 gene, IMPACT gene, ABCB1 gene, BCL2 gene and P4HTM gene. The related lipids are Liposomes. The related experimental models are Xenograft Model.
To understand associated biological information of Paclitaxel, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Paclitaxel is suspected in athymia, Multiple Sulfatase Deficiency Disease, Peripheral Neuropathy, Pulmonary Embolism, Painful Bladder Syndrome, Neuropathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Paclitaxel
MeSH term | MeSH ID | Detail |
---|---|---|
Enterobacteriaceae Infections | D004756 | 5 associated lipids |
Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Paclitaxel through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.' (Wang E et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Svenson S | What nanomedicine in the clinic right now really forms nanoparticles? | 2014 Mar-Apr | Wiley Interdiscip Rev Nanomed Nanobiotechnol | pmid:24415653 |
Bevis KS et al. | Combination therapy with paclitaxel, carboplatin and megestrol acetate for the management of advanced stage or recurrent carcinoma of the endometrium: a phase II study. | 2014 Mar-Apr | J Reprod Med | pmid:24724218 |
Hahn A et al. | Neoadjuvant chemotherapy for breast cancer with weekly nab-paclitaxel followed by epirubicin and cyclophosphamide--results of a case series. | 2014 Mar-Apr | In Vivo | pmid:24632979 |
Ferrari LA et al. | Are antineoplastic drug acute hypersensitive reactions a submerged or an emergent problem? Experience of the Medical Day Hospital of the Fondazione IRCCS Istituto Nazionale Tumori. | 2014 Jan-Feb | Tumori | pmid:24675484 |
Chen Y et al. | Comparison of salvage chemoradiation versus salvage surgery for recurrent esophageal squamous cell carcinoma after definitive radiochemotherapy or radiotherapy alone. | 2014 Feb-Mar | Dis. Esophagus | pmid:23088212 |
Liu J et al. | Maintenance therapy with autologous cytokine-induced killer cells in patients with advanced epithelial ovarian cancer after first-line treatment. | 2014 Feb-Mar | J. Immunother. | pmid:24509174 |
Yokobori T et al. | FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs. | 2014 | Mol. Cancer Res. | pmid:24165483 |
Ferber S et al. | Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release. | 2014 | Cancer Lett. | pmid:24614283 |
Kala S et al. | Combination of dendrimer-nanovector-mediated small interfering RNA delivery to target Akt with the clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer. | 2014 | J. Med. Chem. | pmid:24592939 |
Hutcheson KA et al. | Long-term functional and survival outcomes after induction chemotherapy and risk-based definitive therapy for locally advanced squamous cell carcinoma of the head and neck. | 2014 | Head Neck | pmid:23780650 |