Paclitaxel

Paclitaxel is a lipid of Prenol Lipids (PR) class. Paclitaxel is associated with abnormalities such as Multiple Sulfatase Deficiency Disease, Peripheral Neuropathy, Pulmonary Embolism, Painful Bladder Syndrome and athymia. The involved functions are known as synergism, Metabolic Inhibition, Drug Efflux, Disease regression and Oxidation. Paclitaxel often locates in Back, Hepatic, Microtubules, Head and Cytoskeleton. The associated genes with Paclitaxel are CDAN1 gene, IMPACT gene, ABCB1 gene, BCL2 gene and P4HTM gene. The related lipids are Liposomes. The related experimental models are Xenograft Model.

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Introduction

To understand associated biological information of Paclitaxel, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Paclitaxel?

Paclitaxel is suspected in athymia, Multiple Sulfatase Deficiency Disease, Peripheral Neuropathy, Pulmonary Embolism, Painful Bladder Syndrome, Neuropathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Paclitaxel

MeSH term MeSH ID Detail
Enterobacteriaceae Infections D004756 5 associated lipids
Neoplasms, Glandular and Epithelial D009375 12 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Paclitaxel

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Paclitaxel through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Paclitaxel?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Paclitaxel?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Paclitaxel?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Paclitaxel?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Paclitaxel?

Xenograft Model

Xenograft Model are used in the study 'The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.' (Wang E et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Paclitaxel

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Authors Title Published Journal PubMed Link
Svenson S What nanomedicine in the clinic right now really forms nanoparticles? 2014 Mar-Apr Wiley Interdiscip Rev Nanomed Nanobiotechnol pmid:24415653
Bevis KS et al. Combination therapy with paclitaxel, carboplatin and megestrol acetate for the management of advanced stage or recurrent carcinoma of the endometrium: a phase II study. 2014 Mar-Apr J Reprod Med pmid:24724218
Hahn A et al. Neoadjuvant chemotherapy for breast cancer with weekly nab-paclitaxel followed by epirubicin and cyclophosphamide--results of a case series. 2014 Mar-Apr In Vivo pmid:24632979
Ferrari LA et al. Are antineoplastic drug acute hypersensitive reactions a submerged or an emergent problem? Experience of the Medical Day Hospital of the Fondazione IRCCS Istituto Nazionale Tumori. 2014 Jan-Feb Tumori pmid:24675484
Chen Y et al. Comparison of salvage chemoradiation versus salvage surgery for recurrent esophageal squamous cell carcinoma after definitive radiochemotherapy or radiotherapy alone. 2014 Feb-Mar Dis. Esophagus pmid:23088212
Liu J et al. Maintenance therapy with autologous cytokine-induced killer cells in patients with advanced epithelial ovarian cancer after first-line treatment. 2014 Feb-Mar J. Immunother. pmid:24509174
Yokobori T et al. FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs. 2014 Mol. Cancer Res. pmid:24165483
Ferber S et al. Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release. 2014 Cancer Lett. pmid:24614283
Kala S et al. Combination of dendrimer-nanovector-mediated small interfering RNA delivery to target Akt with the clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer. 2014 J. Med. Chem. pmid:24592939
Hutcheson KA et al. Long-term functional and survival outcomes after induction chemotherapy and risk-based definitive therapy for locally advanced squamous cell carcinoma of the head and neck. 2014 Head Neck pmid:23780650