MeSH term | MeSH ID | Detail |
---|---|---|
Enterobacteriaceae Infections | D004756 | 5 associated lipids |
Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
Paclitaxel is a lipid of Prenol Lipids (PR) class. Paclitaxel is associated with abnormalities such as Multiple Sulfatase Deficiency Disease, Peripheral Neuropathy, Pulmonary Embolism, Painful Bladder Syndrome and athymia. The involved functions are known as synergism, Metabolic Inhibition, Drug Efflux, Disease regression and Oxidation. Paclitaxel often locates in Back, Hepatic, Microtubules, Head and Cytoskeleton. The associated genes with Paclitaxel are CDAN1 gene, IMPACT gene, ABCB1 gene, BCL2 gene and P4HTM gene. The related lipids are Liposomes. The related experimental models are Xenograft Model.
To understand associated biological information of Paclitaxel, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Paclitaxel is suspected in athymia, Multiple Sulfatase Deficiency Disease, Peripheral Neuropathy, Pulmonary Embolism, Painful Bladder Syndrome, Neuropathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Paclitaxel
MeSH term | MeSH ID | Detail |
---|---|---|
Enterobacteriaceae Infections | D004756 | 5 associated lipids |
Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Paclitaxel through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.' (Wang E et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chambers CJ et al. | Eruptive purpuric papules on the arms; a case of chemotherapy-induced inflammation of actinic keratoses and review of the literature. | 2014 | Dermatol. Online J. | pmid:24456949 |
Watanabe A et al. | Stathmin1 regulates p27 expression, proliferation and drug resistance, resulting in poor clinical prognosis in cholangiocarcinoma. | 2014 | Cancer Sci. | pmid:24708177 |
Pillai RN et al. | Interferon alpha plus 13-cis-retinoic acid modulation of BCL-2 plus paclitaxel for recurrent small-cell lung cancer (SCLC): an Eastern Cooperative Oncology Group study (E6501). | 2014 | Cancer Chemother. Pharmacol. | pmid:24858462 |
Krivak TC et al. | A chemoresponse assay for prediction of platinum resistance in primary ovarian cancer. | 2014 | Am. J. Obstet. Gynecol. | pmid:24530815 |
Miki M et al. | [A case of locally advanced and metastatic breast cancer successfully treated with combination therapy of paclitaxel and bevacizumab]. | 2014 | Gan To Kagaku Ryoho | pmid:25132039 |
Hariri G et al. | Sequential targeted delivery of paclitaxel and camptothecin using a cross-linked "nanosponge" network for lung cancer chemotherapy. | 2014 | Mol. Pharm. | pmid:24215299 |
Albrethsen J et al. | Proteomics of cancer cell lines resistant to microtubule-stabilizing agents. | 2014 | Mol. Cancer Ther. | pmid:24252851 |
Young RJ et al. | Vascular-targeted agents for the treatment of angiosarcoma. | 2014 | Cancer Chemother. Pharmacol. | pmid:24253175 |
Fava LL and Villunger A | Stop competing, start talking! | 2014 | EMBO J. | pmid:25063676 |
Sota Y et al. | Construction of novel immune-related signature for prediction of pathological complete response to neoadjuvant chemotherapy in human breast cancer. | 2014 | Ann. Oncol. | pmid:24356621 |