ursolic acid

Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.

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Introduction

To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ursolic acid?

ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ursolic acid

MeSH term MeSH ID Detail
Dermatitis, Contact D003877 59 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Carcinogenesis D063646 3 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with ursolic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ursolic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ursolic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ursolic acid?

Related references are published most in these journals:

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What genes are associated with ursolic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ursolic acid?

Mouse Model

Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).

Knock-out

Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Cancer Model

Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ursolic acid

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Authors Title Published Journal PubMed Link
Gao YS et al. Inhibitory effect of ursolic acid and oleanolic acid from Eriobotrya fragrans on A549 cell viability in vivo. 2016 Genet. Mol. Res. pmid:27323036
Blanchaert B et al. Bioanalytical LC/MS study of potential bacterial transglycosylation inhibitors. 2016 J Pharm Biomed Anal pmid:26782294
Miao J et al. Chemical Composition and Bioactivities of Two Common Chaenomeles Fruits in China: Chaenomeles speciosa and Chaenomeles sinensis. 2016 J. Food Sci. pmid:27384225
Mendes VIS et al. Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells. 2016 Eur J Med Chem pmid:27484517
Shan J et al. Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer. 2016 Protein Cell pmid:27472952
Mishra T et al. Isolation, Characterization and Anticancer Potential of Cytotoxic Triterpenes from Betula utilis Bark. 2016 PLoS ONE pmid:27453990
Yealland G et al. Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes. 2016 Neurosci. Lett. pmid:27412236
Wang CM et al. The Pleiotropic Antibacterial Mechanisms of Ursolic Acid against Methicillin-Resistant Staphylococcus aureus (MRSA). 2016 Molecules pmid:27399657
Liang W et al. Ursolic acid attenuates beta-amyloid-induced memory impairment in mice. 2016 Arq Neuropsiquiatr pmid:27332074
Wang Y et al. Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury. 2016 Drug Des Devel Ther pmid:27274199